Inpatient Management of Adults and Children with Type 1 Diabetes

Tridgell, David; Tridgell, Angela; Hirsch, Irl B.

doi:10.1016/j.ecl.2010.05.014

Cited by 14 publications

(4 citation statements)

References 35 publications

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“…Peña et al (15) reported that hypoglycemia rather than BG fluctuation was correlated with vascular dysfunction in a pediatric population with T1DM. Moreover, several studies have shown that the most prominent barrier for tight glycemic control is the fear of hypoglycemia (16,17). In our study, there was no statistically significant difference between the groups with regard to hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

Higher-Than-Conventional Subcutaneous Regular Insulin Doses in Diabetic Ketoacidosis in Children and Adolescents

Bağ¹,

Tunç²,

Nalbantoğlu³

et al. 2017

Jcrpe

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Objective:To evaluate the effect of initial insulin dosage on glycemic control in the first 48 hours of subcutaneous regular insulin therapy after resolution of diabetic ketoacidosis (DKA).Methods:Records of patients with DKA hospitalized in the past 3 years [n=76, median age=10.0 (6.0-12.0) years, Male/Female: 44/32] were reviewed. The patients were designated into two groups according to distribution of starting doses of subcutaneous insulin. Group 1 (n=28) received a median dose of 1.45 U/kg/day (1.41-1.5) and group 2 (n=48) a median dose of 0.96 U/kg/day (0.89-1). Clinical and laboratory data were analyzed.Results:Median, minimum, and maximum blood glucose levels of Group 1 in the first 48 hours of treatment were significantly lower than that of Group 2 [213 (171-242) vs. 255 (222-316), p=<0.001; 102 (85-151) vs. 129 (105-199), p=0.004; and 335 (290-365) vs. 375 (341-438), p=0.001, respectively]. The number of patients who experienced hypoglycemia (<70 mg/dL) were similar [Group 1, 5 (17.9%) vs. Group 2, 4 (8.3%), p=0.276] and none had severe hypoglycemia. In Group 1, the ratio of blood glucose levels within the target range (100-200 mg/dL) were higher (37.5% vs. 12.5%) and the number of results >200 mg/dL were lower (50% vs. 81.3%) compared to Group 2 (p=0.001 and p<0.001, respectively).Conclusion:After resolution of DKA, a higher initial dose of 1.4-1.5 U/kg/day regular insulin is associated with better glycemic control in children and adolescents without an increase in risk of hypoglycemia.

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Section: Discussionmentioning

confidence: 99%

Higher-Than-Conventional Subcutaneous Regular Insulin Doses in Diabetic Ketoacidosis in Children and Adolescents

Bağ¹,

Tunç²,

Nalbantoğlu³

et al. 2017

Jcrpe

View full text Add to dashboard Cite

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“…A real-world experiment was carried out using a remotely piloted aerial system (RPAS) equipped with the ArduPilot open source flight controller [29]. ArduPilot was used to record data from the IMU (350 Hz), magnetometer (10 Hz), and GNSS (5 Hz) over a period of six minutes while the plane flew around an area of approximately 400 m × 400 m. The GNSS measurements were converted from Latitude-Longitude-Altitude (LLA) into a local North-East-Down (NED) frame by using the first GNSS position measurement as a reference.…”

Section: Methodsmentioning

confidence: 99%

Autonomous Error and Constructive Observer Design for Group Affine Systems

Goor

Mahony

2021

2021 60th IEEE Conference on Decision and Control (CDC)

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Inertial Navigation Systems (INS) are algorithms that fuse inertial measurements of angular velocity and specific acceleration with supplementary sensors including GNSS and magnetometers to estimate the position, velocity and attitude, or extended pose, of a vehicle. The industry-standard extended Kalman filter (EKF) does not come with strong stability or robustness guarantees and can be subject to catastrophic failure. This paper exploits a Lie group symmetry of the INS dynamics to propose the first nonlinear observer for INS with error dynamics that are almost-globally asymptotically and locally exponentially stable, independently of the chosen gains. The observer is aided only by a GNSS measurement of position. As expected, the convergence guarantee depends on persistence of excitation of the vehicle's specific acceleration in the inertial frame. Simulation results demonstrate the observer's performance and its ability to converge from extreme errors in the initial state estimates.

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“…Any patient treated with insulin is at risk for hypoglycemia and must be trained to monitor finger‐stick blood glucose and appropriately treat hypoglycemia. Table summarizes the various insulin analogs, peak onset of action, and duration of action . Renal dysfunction is associated with prolonged half‐life of insulin, and lower doses of insulin may be required to avoid hypoglycemia .…”

Section: Treatment and Managementmentioning

confidence: 99%

New‐onset diabetes mellitus after pediatric liver transplantation

Regelmann

Goldis

Arnon

2015

Pediatric Transplantation

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In the first five yr after liver transplant, approximately one in 10 pediatric recipients will develop NODAT. Factors associated with higher risk for NODAT have been difficult to identify due to lack of uniformity in reporting and data collection. Limited studies have reported higher risk in those who are at an older age at transplant, those with high-risk ethnic backgrounds, and in those with particular underlying conditions, such as CF and primary sclerosing cholangitis. Immunosuppressive medications, including tacrolimus, cyclosporine A, GC, and sirolimus, have been implicated as contributing to NODAT, to varying degrees. Identifying those at highest risk, appropriately screening, and diagnosing NODAT is critical to initiating timely treatment and avoiding potential complications. In the pediatric population, treatment is limited primarily to insulin, with some consideration for metformin. Children with NODAT should be monitored carefully for complications of DM, including microalbuminuria, hypertension, hyperlipidemia, and retinopathy.

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Inpatient Management of Adults and Children with Type 1 Diabetes

Cited by 14 publications

References 35 publications

Higher-Than-Conventional Subcutaneous Regular Insulin Doses in Diabetic Ketoacidosis in Children and Adolescents

Higher-Than-Conventional Subcutaneous Regular Insulin Doses in Diabetic Ketoacidosis in Children and Adolescents

Autonomous Error and Constructive Observer Design for Group Affine Systems

New‐onset diabetes mellitus after pediatric liver transplantation

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