Inpatient Management of T2DM and Hyperglycemia in Older Adults

DeCarlo, Kristen; Wallia, Amisha

doi:10.1007/s11892-019-1209-3

Cited by 12 publications

(8 citation statements)

References 60 publications

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“…With this method, the timing for implant placement is more consistent with the clinical situation. In particular, considering that more younger people are getting implants in prosthetic restoration (Dreyer et al., 2018), these patients could have undergone an implant therapy years before the possibility of developing T2DM at middle age or old age (DeCarlo & Wallia, 2019). Even under controlled blood glucose levels, diabetic patients still need a longer time for bone healing (de Molon et al., 2013).…”

Section: Discussionmentioning

confidence: 99%

Development of a rat model for type 2 diabetes mellitus peri‐implantitis: A preliminary study

Shrestha

et al. 2021

Oral Diseases

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Objective To develop an in vivo model to simulate the complex internal environment of diabetic peri‐implantitis (T2DM‐PI) model for a better understanding of peri‐implantitis in type 2 diabetic patients. Materials and methods Maxillary first molars were extracted in Sprague‐Dawley (SD) rats, and customized cone‐shaped titanium implants were installed in the extraction sites. Thereafter, implants were uncovered and customized abutments were screwed into implants. A high‐fat diet and a low‐dose injection of streptozotocin were utilized to induce T2DM. Finally, LPS was locally injected in implant sulcus to induce peri‐implantitis. Results In the present study, T2DM‐PI model has been successfully established. Imaging analysis revealed that abundant inflammatory cells infiltrated in the soft tissue in T2DM‐PI group with concomitant excessive secretion of inflammatory cytokines. Moreover, higher expression of MMP and increased number of osteoclasts led to collagen disintegration and bone resorption in T2DM‐PI group. Conclusions These results describe a novel rat model which stimulate T2DM‐PI in vivo, characterized by overwhelming inflammatory response and bone resorption. This model has a potential to be used for investigation of initiation, progression and interventional therapy of T2DM‐PI.

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Section: Discussionmentioning

confidence: 99%

Development of a rat model for type 2 diabetes mellitus peri‐implantitis: A preliminary study

Shrestha

et al. 2021

Oral Diseases

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“…Hypoglycemia is a common symptom and a relevant burden in T2DM patients [7]. Diabetics with hypoglycemia symptoms such as dizziness, nausea, physical fatigue, often due to the overdose of oral drug and injection of insulin therapy [8,9].…”

Section: Introductionmentioning

confidence: 99%

The influence of hypoglycemia on the specific quality of life in type 2 diabetes mellitus: a comparative cross-sectional study of diabetics with and without hypoglycemia in Xi’an, China

Zhang³

et al. 2021

Health Qual Life Outcomes

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Purpose This study aims to explore the incidence of hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and the influence of hypoglycemia on the specific quality of life in T2DM patients. Methods It was a comparative cross-sectional study consisting of 519 T2DM patients in Xi'an, China and patients were investigated by self-reported hypoglycemia and specific quality of life questionnaires from September 2019 to January 2020. Descriptive analysis, t-test, Chi-square test, hierarchical regression analysis and stepwise multiple regression analysis were applied to assess the influence of hypoglycemia on the specific quality of life. Results The incidence of hypoglycemia in T2DM patients was 32.18%. The mean score of specific quality of life in diabetes without hypoglycemia was 57.33 ± 15.36 and was 61.56 ± 17.50 in those with hypoglycemia, which indicated that hypoglycemia had a serious impact on the quality of life of diabetics (t = − 5.172, p = 0.000). In the Univariate analysis of specific quality of life, age, education background, marital status, living status, duration of diabetes, monthly income per capita were independent and significant factors associated with specific quality of life of two groups of T2DM patients (p < 0.05). In the hierarchical regression analysis, the duration of the diabetes more than 11 years and the frequency of hypoglycemia more than 6 times in half a year entered the equation of specific quality of life of 519 diabetics respectively (p < 0.001). In multiple linear regression analysis, age, marital status and income all entered the regression equation of quality of life of the two groups (p < 0.05). Conclusion Hypoglycemia will have a serious impact on the quality of life of T2DM patients. In order to improve the living quality in diabetics, effective measurements should be taken to strengthen the management of blood glucose and to avoid hypoglycemia.

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“…Subcutaneous insulin administration following a basal-bolus or a basal-plus regimen is the favored strategy for noncritically ill hospitalized patients, while the use of paper or computerized intravenous infusion protocols is endorsed for those critically ill. 7 Nonetheless, insulin therapy is known to increase the risk for hypoglycemia and is also often considered cumbersome and complicated, requiring frequent point of care blood glucose (BG) monitoring and intensive staff training and exposure. 8 Despite the lack of recommendations, the use of oral antidiabetic agents is a common practice in the hospital setting. Although likely effective in some patients with mild hyperglycemia, agents such as metformin and sulfonylureas should generally be avoided in acutely ill patients with contraindications or at risk for lactic acidosis or hypoglycemia.…”

Section: Key Ideasmentioning

confidence: 99%

“…Although likely effective in some patients with mild hyperglycemia, agents such as metformin and sulfonylureas should generally be avoided in acutely ill patients with contraindications or at risk for lactic acidosis or hypoglycemia. 8…”

Section: Key Ideasmentioning

confidence: 99%

Hospital Diabetes Meeting 2020

Umpiérrez

Rushakoff²,

Seley

et al. 2020

J Diabetes Sci Technol

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Patients with diabetes may experience adverse outcomes related to their glycemic control when hospitalized. Continuous glucose monitoring systems, insulin-dosing software, enhancements to the electronic health record, and other medical technologies are now available to improve hospital care. Because of these developments, new approaches are needed to incorporate evolving treatments into routine care. With the goal of educating healthcare professionals on the most recent practices and research for managing diabetes in the hospital, Diabetes Technology Society hosted the Virtual Hospital Diabetes Meeting on April 24-25, 2020. Because of the coronavirus disease 2019 (COVID-19) pandemic, the meeting was restructured to be held virtually during the national lockdown to ensure the safety of the participants and allow them to remain at their posts treating COVID-19 patients. The meeting focused on (1) inpatient management and perioperative care, (2) diabetic ketoacidosis and hyperglycemic hyperosmolar state, (3) computer-guided insulin dosing, (4) Coronavirus Disease 2019 and diabetes, (5) technology, (6) hypoglycemia, (7) data and cybersecurity, (8) special situations, (9) glucometrics and insulinometrics, and (10) quality and safety. This meeting report contains summaries of each of the ten sessions. A virtual poster session will be presented within two months of the meeting.

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Inpatient Management of T2DM and Hyperglycemia in Older Adults

Cited by 12 publications

References 60 publications

Development of a rat model for type 2 diabetes mellitus peri‐implantitis: A preliminary study

Development of a rat model for type 2 diabetes mellitus peri‐implantitis: A preliminary study

The influence of hypoglycemia on the specific quality of life in type 2 diabetes mellitus: a comparative cross-sectional study of diabetics with and without hypoglycemia in Xi’an, China

Hospital Diabetes Meeting 2020

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