Insect Growth Regulators for Insect Pest Control

Masih, Sanjay C.; Ahmad, Bhat Rayees

doi:10.20546/ijcmas.2019.812.030

Cited by 14 publications

(2 citation statements)

References 4 publications

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“…The target molecule of IGRs is specific to insects, resulting in lower toxicity to non-target other animals, including humans, compared to other insecticides, thereby minimizing their impact on the environment [ 37 ]. IGRs classified in (2), (3), and (4) inhibit in vivo biosynthetic reactions through several mechanisms, while IGRs classified in (1) and (5) impact the binding of insect hormones, JHs and ecdysteroids by disrupting their receptors.…”

Section: Insect Growth Regulators (Igrs)mentioning

confidence: 99%

Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators

Ebihara

Niwa

2023

Biomolecules

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Glutathione S-transferases (GSTs) are conserved in a wide range of organisms, including insects. In 2014, an epsilon GST, known as Noppera-bo (Nobo), was shown to regulate the biosynthesis of ecdysteroid, the principal steroid hormone in insects. Studies on fruit flies, Drosophila melanogaster, and silkworms, Bombyx mori, demonstrated that loss-of-function mutants of nobo fail to synthesize ecdysteroid and die during development, consistent with the essential function of ecdysteroids in insect molting and metamorphosis. This genetic evidence suggests that chemical compounds that inhibit activity of Nobo could be insect growth regulators (IGRs) that kill insects by disrupting their molting and metamorphosis. In addition, because nobo is conserved only in Diptera and Lepidoptera, a Nobo inhibitor could be used to target IGRs in a narrow spectrum of insect taxa. Dipterans include mosquitoes, some of which are vectors of diseases such as malaria and dengue fever. Given that mosquito control is essential to reduce mosquito-borne diseases, new IGRs that specifically kill mosquito vectors are always in demand. We have addressed this issue by identifying and characterizing several chemical compounds that inhibit Nobo protein in both D. melanogaster and the yellow fever mosquito, Aedes aegypti. In this review, we summarize our findings from the search for Nobo inhibitors.

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Section: Insect Growth Regulators (Igrs)mentioning

confidence: 99%

Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators

Ebihara

Niwa

2023

Biomolecules

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“…Mastering these properties, humans have used the available hormones of insects or synthetic substances to inhibit the growth and development of insects (inhibition of chitin synthesis-CSI). In addition, people also use anti-hormonal substances (antihormone) to prevent the formation of hormones, so that the insect does not pass a certain stage of development and then dies [33].…”

Section: Insect Growth Regulators (Igr)mentioning

confidence: 99%

Application of Botanical Pesticides in Organic Agriculture Production: Potential and Challenges

Dao

Dao²,

et al. 2021

Vietnam J. Sci. Technol.

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In the context of agricultural pest management, botanical pesticides are best suited for use in organic food (agricultural) production, due to their safety to humans and the environment compared to conventional pesticides. Compounds of plant origin can be highly effective, with diverse and multiple mechanisms of action, while having low toxicity towards non-target organisms. However, the large-scale application of these products for pest control is limited by their poor stability and other technological issues. An overview of botanical pesticides is presented in this paper. Trends and challenges in the research and application of botanical pesticides in Vietnam are also discussed.

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Roles of Improved Formulations and Fixatives in the Development of Nanobioinsecticide

Adetuyi,

Olajide,

Adetunji

2024

Handbook of Agricultural Biotechnology

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Insect Growth Regulators for Insect Pest Control

Cited by 14 publications

References 4 publications

Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators

Compounds Inhibiting Noppera-bo, a Glutathione S-transferase Involved in Insect Ecdysteroid Biosynthesis: Novel Insect Growth Regulators

Application of Botanical Pesticides in Organic Agriculture Production: Potential and Challenges

Roles of Improved Formulations and Fixatives in the Development of Nanobioinsecticide

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