Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors

Evans, Peter; Maqueira, Braudel

doi:10.1007/s10158-005-0001-z

Cited by 250 publications

(240 citation statements)

References 53 publications

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“…By the year 2004, 10 of these receptors had been cloned and characterized (Tierney, 2001;Blenau and Baumann, 2001;Clark et al, 2004). Several recent efforts have reduced the number of uncharacterized monoaminergic receptors to roughly 3 out of 19 (Balfanz et al, 2005;Srivastava et al, 2005;Maqueira et al, 2005;Cazzamali et al, 2005;Evans and Maqueira, 2005).…”

Section: Monoaminergic Gpcr Signaling Is Conserved Across Speciesmentioning

confidence: 99%

Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family

Clark

Baro

2007

Comparative Biochemistry and Physiology Part B: Biochemistry an

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The pyloric network is an important model system for understanding neuromodulation of rhythmic motor behaviors like breathing or walking. Dopamine (DA) differentially modulates neurons within the pyloric network. However, while the electrophysiological actions of DA have been well characterized, nothing is known about the signaling events that mediate its effects. We have begun a molecular characterization of DA receptors (DARs) in this invertebrate system. Here, we describe the cloning and characterization of the lobster D 2 receptor, D 2αPan . We found that when expressed in HEK cells, the D 2αPan receptor is activated by DA, but not other monoamines endogenous to the lobster nervous system. This receptor positively couples with cAMP through multiple Gi/o proteins via two discrete pathways: 1) a Gα mediated inhibition of adenylyl cyclase (AC), leading to a decrease in cAMP and 2) a Gβγ mediated activation of Phospholipase Cβ (PLCβ), leading to an increase in cAMP. Alternate splicing alters the potency and efficacy of the receptor, but does not affect monoamine specificity. Finally, we show that arthropod D 2 receptor coupling with cAMP varies with the cellular milieu.

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Section: Monoaminergic Gpcr Signaling Is Conserved Across Speciesmentioning

confidence: 99%

Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family

Clark

Baro

2007

Comparative Biochemistry and Physiology Part B: Biochemistry an

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“…26,[131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146][147][148] Based on the structural and signaling similarities between cloned D. melanogaster octopaminergic receptors and vertebrate adrenergic receptors, Evans and Maqueira proposed a new classification. 149 According to this new classification ( Figure 4B), octopaminergic receptors were grouped into three classes, ie, α-adrenergic-like (OCTα-R), β-adrenergic-like (OCTβ-R), and octopaminergic/tyraminergic (OCT/TYR-R) or tyraminergic (TYR-R). 149 The OCTα-R class shows sequence homology with vertebrate α1-adrenergic receptors.…”

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confidence: 99%

Review of octopamine in insect nervous systems

Farooqui¹

2012

OAIP

148

155

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Octopamine (OCT) belongs to a group of compounds known as biogenic amines. OCT, a monohydroxylic analog of norepinephrine, is found in both vertebrate and invertebrate nervous systems. OCT is present in relatively high concentrations in the neuronal and nonneuronal tissues of most invertebrate species studied. However, OCT occurs as a trace amine in vertebrates where its physiological significance remains uncertain. OCT acts as a neurotransmitter, neuromodulator, and neurohormone in insect nervous systems where it prominently influences multiple physiological events. In the peripheral nervous system, OCT modulates the activity of flight muscles, peripheral organs, and most sense organs. In the central nervous system, OCT is essential for the regulation of motivation, desensitization of sensory inputs, arousal, initiation, and maintenance of various rhythmic behaviors, hygiene behavior, and complex social behaviors, including establishment of labor, as well as learning and memory. As a neurotransmitter, OCT regulates endocrine gland activity and controls the emission of light in the firefly lantern. As a neurohormone, OCT is released into hemolymph, transported to target tissues, and induces mobilization of lipids and carbohydrates, preparing insects for a period of extended activity or assisting recovery from a period of increased energy demand. OCT modulates hemocytic nodulation in nonimmune larvae and enhances phagocytosis as a neurohormone. OCT exerts its effects by binding to specific receptors belonging to the superfamily of G protein-coupled receptors and shares the structural motif of seven transmembrane domains. Activation of octopaminergic receptor types is coupled with different second messenger pathways depending on the species, tissue source, receptor type, and cell line used for expression of the cloned receptor. OCT-mediated generation of second messengers is associated with changes in cellular response, affecting insect behaviors. This review describes the roles of OCT in insect nervous systems at the behavioral and molecular levels.

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“…Octopamine in insects is believed to be comparable to norepinephrine in vertebrates. This is because of its similarities in its chemical structure, but also its physiological action (16)(17)(18)). An octopamine receptor has previously been isolated and characterized from the American cockroach, Periplaneta americana (Pa oa1) and was used to describe monoterpenoid interactions here (19).…”

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confidence: 99%

Quantitative Structure-Activity Relationships (QSARs) of Monoterpenoids at an Expressed American Cockroach Octopamine Receptor

Gross

Kimber

Day

et al. 2013

ACS Symposium Series

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Monoterpenoids are found in essential oils from numerous plant families. Octopamine is a biogenic monoamine found within various invertebrates, including insects. Octopamine exerts its physiological effects through the activation of G-protein-coupled receptors (GPCRs). GPCRs are an under-utilized receptor target in the agrochemical industry. Here we report the expression of an octopamine receptor from the brain of the American cockroach (Periplaneta americana) inSaccharomyces cerevisiae, creating a ligand-independent histidine-auxotrophic assay. The majority of monoterpenoids acted as an inverse agonist in this system. Three QSAR models show that electronic properties are most important for monoterpenoid interaction with this octopamine receptor in this yeast assay.

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Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors

Cited by 250 publications

References 53 publications

Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family

Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family

Review of octopamine in insect nervous systems

Quantitative Structure-Activity Relationships (QSARs) of Monoterpenoids at an Expressed American Cockroach Octopamine Receptor

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