Insect-Protected Event DAS-81419-2 Soybean (<i>Glycine max</i>L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

Fast, Brandon J.; Schafer, Ariane C.; Johnson, Tempest Y.; Potts, Brian; Herman, Rod A.

doi:10.1021/jf505015y

Cited by 19 publications

(17 citation statements)

References 108 publications

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“…On the other hand, Herman et al (2011) Recent studies have examined other issues, such as the ecological interactions of Roundup Ready 2 YieldR-soybean (MON 89788), without founding effects of the genetic modification that could result in increased pest potential or adverse environmental impact of that transgenic soybean (Horak et al, 2015). In turn, Fast et al (2015) determined the nutrient and antinutrient composition of event DA-81419-2 soybean, which was equivalent to non-transgenic soybean.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Safety assessment of GM plants: An updated review of the scientific literature

Domingo

2016

Food and Chemical Toxicology

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Safety assessment of GM plants: An updated review of the scientific literature

Domingo

2016

Food and Chemical Toxicology

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“…1 However, over 100 scientific studies on GE-crop composition have been conducted over the past 25 years and have clearly demonstrated that transgenesis is less likely to cause unexpected changes in crop composition compared with traditional breeding methods. 2,3 Therefore, transgenesis has been shown to not create novel or increased risks compared with traditional breeding. 2,4,5 Despite this wealth of evidence, the complexity and cost of crop-composition studies to support GE-crop approvals have increased tremendously over time, and some scientists are still suggesting even further complexity.…”

Section: ■ Introductionmentioning

confidence: 99%

EFSA Genetically Engineered Crop Composition Equivalence Approach: Performance and Consistency

Herman

Huang

Fast

et al. 2019

J. Agric. Food Chem.

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The European Food Safety Authority (EFSA) oversees the safety assessment of genetically engineered (GE) crops in the European Union and has developed a study design and statistical approach for assessing the compositional equivalency between a GE crop and the corresponding non-GE crop on the basis of the results from a small number of concurrently grown reference lines. Confidence limits around the differences in mean analyte composition between the GE variety and the reference lines are compared with equivalence limits on the basis of the variability of the reference lines. Here, we evaluated the performance and consistency of the equivalence conclusions using a non-GE variety that is, by definition, equivalent to the non-GE crop. Using this approach across the same analytes with the same non-GE variety, it was found that equivalence could not be concluded for 19.7, 22.9, 25.4, and 53.5% of the analytes in four separate studies. In addition, equivalency conclusions for the same analyte often differed from study to study. These results call into question the consistency and value of this approach in the risk assessment of GE crops.

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“…In addition, several research teams reported no alteration in the total daidzein, total genistein. and total glycitein in soybeans being genetically modified for herbicide tolerance, insect resistance, and modified fatty acid profile (Padgette et al, 1996;Taylor et al, 1999;Mc Cann et al, 2005;Lundry et al, 2008;Berman et al, 2009Berman et al, , 2010Zhou et al, 2011a;Lepping et al, 2013;Fast et al, 2015).…”

Section: Factors Influencing Isoflavone Contentmentioning

confidence: 99%