Insecticide Residues in Milk, Determination of Methoxychlor and/or Metabolites in Milk Following Topical Application to Dairy Cows

Cluett, M. L.; Lowen, W. K.; Pease, Harlan L.; Woodhouse, Charlotte

doi:10.1021/jf60110a006

Cited by 9 publications

(1 citation statement)

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“…Excretion in milk.-The rate of excretion in the milk is proportional to dosage for DDT (31,157), dieldrin (31,91), aldrin, heptachlor, methoxychlor (31,158), heptachlor epoxide (159,160) , and endrin (161). In fact, the slopes of the lines which relate concentration in milk to concentration in feed have been represented as identical for most of these compounds (31).…”

Section: Excretion and Storage Lossmentioning

confidence: 99%

Review of the Metabolism of Chlorinated Hydrocarbon Insecticides Especially in Mammals

Wj¹

1965

Annu. Rev. Pharmacol.

119

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This review discusses the absorption, storage, biotransformation, and excretion of chlorinated hydrocarbon insecticides; thus, it emphasizes those aspects of physiology that can be studied by the methods of analytical or ganic chemistry. The broader aspects of toxicity, as they relate to the me tabolism of these materials, were discussed by Winteringham & Barnes (1).This review emphasizes mammalian metabolism of the compounds, but con tains some information on their metaboli sm by other organisms, a subject that has already been reviewed by Perry (2). In relation to mammals, great est interest centers in numerous repeated doses that produce no obvious in jury and that are so small that they might be encountered under practical conditions in the use of insecticides. For this reason, DDT and related re sidual insecticides are emphasized, but some information is given on the chlorinated hydrocarbon fumigants.

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