Insecticide susceptibility status of Phlebotomus argentipes and polymorphisms in voltage-gated sodium channel (vgsc) gene in Kala-azar endemic areas of West Bengal, India

Sardar, Ashif Ali; Saha, Pabitra; Chatterjee, Moytrey; Bera, Dilip Kumar; Biswas, Prasanta Kumar; Maji, Dipankar; Guha, Subhasish Kamal; Basu, Nandita; Maji, Ardhendu Kumar

doi:10.1016/j.actatropica.2018.06.005

Cited by 18 publications

(25 citation statements)

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“…The development of resistance of sandfly vectors to pyrethroids due to their continuing use in future may pose a biological challenge in VL elimination efforts in future. Detection of a non-synonymous mutation L1014F in a voltage-gated sodium channel gene in the wild population of P. argentipes in India that was found to be associated with resistance to DDT and deltamethrin signals pyrethroid tolerability and possible emergence of resistance to pyrethroids [22]. Resistance has been detected in the wild population of sandflies in areas where pyrethroids have long been applied [23].…”

Section: Discussionmentioning

confidence: 99%

Insecticide susceptibility of Phlebotomus argentipes sandflies, vectors of visceral leishmaniasis in India

Dinesh

Hassan

Kumar

et al. 2021

Tropical Med Int Health

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objectives Indoor residual spraying (IRS) with insecticides is the main vector control intervention for the elimination of visceral leishmaniasis in India. After a change in IRS policy in 2015 due to widespread resistance of Phlebotomus argentipes to DDT, IRS with DDT was replaced with alphacypermethrin IRS in 2016. The objective of the present study was to evaluate the susceptibility of P. argentipes to DDT and its alternatives, namely malathion and pirimiphos-methyl (organophosphates); alpha-cypermethrin, deltamethrin, lambda-cyhalothrin and permethrin (pyrethroids), and bendiocarb and propoxur (carbamates), in support of visceral leishmaniasis elimination in India.methods Phlebotomus argentipes sandflies were collected from the visceral-leishmaniasis endemic states of Bihar, Jharkhand and West Bengal. In the WHO tube tests, the phenotypic susceptibility of F1, 2-day old, non-blood fed females were determined against filter papers impregnated with DDT 4%, malathion 5%, pirimiphos-methyl 0.25%, alpha-cypermethrin 0.05%, deltamethrin 0.05%, lambda-cyhalothrin 0.05%, permethrin 0.75%, bendiocarb 0.1% and propoxur 0.1%, which were sourced from Universiti Sains Malaysia. The knockdown of sandflies after 1-h exposure and mortality at 24 h after the 1-h exposure period were scored.results Mean mortality of P. argentipes 24 h after exposure in tube tests was 22.6% for DDT and ≥ 98% for other insecticide-impregnated papers tested.conclusion Phlebotomus argentipes continues to be highly resistant to DDT with no reversal of resistance after DDT's withdrawal from IRS. P. argentipes was fully susceptible to pyrethroid, organophosphate and carbamate insecticides tested. Regular monitoring is warranted for insecticide resistance management in sandfly vectors.

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Section: Discussionmentioning

confidence: 99%

Insecticide susceptibility of Phlebotomus argentipes sandflies, vectors of visceral leishmaniasis in India

Dinesh

Hassan

Kumar

et al. 2021

Tropical Med Int Health

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“…papatasi populations from West Bengal and Bihar. Indicatively, a series of studies report DDT 4% exposure mortality rates ranging from 43% to 100% [ 11 , 75 – 77 ] and KDT 50 (i.e., time of exposure causing 50% KD of the tested population) values exceeding 30 minutes [ 76 ] in both vector species. Resistance has also been recorded against the OC dieldrin in West Bengal and Uttar Pradesh P .…”

Section: Methodsmentioning

confidence: 99%

“…argentipes and P . papatasi Indian populations have occasionally displayed evidence of resistance against carbamates (i.e., propoxur) and OPs (i.e., malathion) [ 11 ], yet the majority of bioassay records against these compounds denoted susceptibility [ 11 , 76 ].…”

Section: Methodsmentioning

confidence: 99%

“…The available kdr mutation reports amount to: (i) the presence of both 1014F and 1014S mutations in the major VL vector P . argentipes in Bihar and West Bengal states, India, with allelic frequencies ranging from 27% to 54% [ 75 , 76 ]; (ii) 1014F occurrence, at a close to 50% allelic frequency in a small number of P . papatasi specimens from Sanliurfa, an important CL focus in Turkey [ 101 ]; and (iii) the presence of the 1014F and 1014S mutant alleles in P .…”

Section: Methodsmentioning

confidence: 99%

“…Sequencing analyses for the presence of other known kdr mutations (i.e., VGSC I1011M, V1016G, and F1020S) in sand fly populations from India, Greece, and Turkey reported their absence (in the respective specimens) [ 75 , 76 , 79 , 102 ], including the non-detection of 1014F/S mutations in the Greek populations (comprising of Phlebotomus neglectus , P . perfiliewi , Phlebotomus simici , and P .…”

Section: Methodsmentioning

confidence: 99%

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Chemical control and insecticide resistance status of sand fly vectors worldwide

et al. 2021

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Background Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key component of leishmaniasis control efforts. Methods and findings We performed a literature review on the current interventions, primarily, insecticide-based used for sand fly control, as well as the global insecticide resistance (IR) status of the main sand fly vector species. Indoor insecticidal interventions, such as residual spraying and treated bed nets are the most widely deployed, while several alternative control strategies are also used in certain settings and/or are under evaluation. IR has been sporadically detected in sand flies in India and other regions, using non-standardized diagnostic bioassays. Molecular studies are limited to monitoring of known pyrethroid resistance mutations (kdr), which are present at high frequencies in certain regions. Conclusions As the leishmaniasis burden remains a major problem at a global scale, evidence-based rational use of insecticidal interventions is required to meet public health demands. Standardized bioassays and molecular markers are a prerequisite for this task, albeit are lagging behind. Experiences from other disease vectors underscore the need for the implementation of appropriate IR management (IRM) programs, in the framework of integrated vector management (IVM). The implementation of alternative strategies seems context- and case-specific, with key eco-epidemiological parameters yet to be investigated. New biotechnology-based control approaches might also come into play in the near future to further reinforce sand fly/leishmaniasis control efforts.

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Impact of Indoor Residual Spray (IRS) of synthetic pyrethroid (alphacypermethrin) on sand fly population in the Kala-azar endemic areas of Malda district, West Bengal, India

Sardar

Saha

Maji

et al. 2022

Int J Trop Insect Sci

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Insecticide susceptibility status of Phlebotomus argentipes and polymorphisms in voltage-gated sodium channel (vgsc) gene in Kala-azar endemic areas of West Bengal, India

Cited by 18 publications

References 35 publications

Insecticide susceptibility of Phlebotomus argentipes sandflies, vectors of visceral leishmaniasis in India

Insecticide susceptibility of Phlebotomus argentipes sandflies, vectors of visceral leishmaniasis in India

Chemical control and insecticide resistance status of sand fly vectors worldwide

Impact of Indoor Residual Spray (IRS) of synthetic pyrethroid (alphacypermethrin) on sand fly population in the Kala-azar endemic areas of Malda district, West Bengal, India

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