Inside Cover: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging (ChemBioChem 1/2017)

Abstract

The inside cover picture shows the concept of a new binary photocage that enables synchronous controlled release of two payloads linked to a single cage unit. This cage is based on photocleavable thioacetal ortho‐nitrobenzaldehyde, and its utility is illustrated by cross‐tethering both an anticancer agent and a fluorescent reporter to the cage. Caging temporarily retains the drug in an inactive state and quenches reporter fluorescence. The extent of light‐controlled dual release is quantifiable by reporter fluorescence measured in situ. This strategy provides new possibilities for real‐time monitoring of drug or effector activation in cellular systems and at delivery sites. More information can be found in the full paper by P. T. Wong, S. K. Choi et al. on page 126 in Issue 1, 2017 (DOI: 10.1002/cbic.201600494).