Inside Front Cover: Rigid, Self‐Assembled Hydrogel Composed of a Modified Aromatic Dipeptide (Adv. Mater. 11/2006)

Mahler, A.; Reches, Meital; Rechter, Meirav; Cohen, Smadar; Gazit, Ehud

doi:10.1002/adma.200690046

Cited by 3 publications

(1 citation statement)

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“…Due to their capability to establish non-covalent interactions and to assume secondary structure elements, peptides have been also identified as potential building blocks for generating hydrogels [22]. Among Gels 2023, 9, 903 2 of 16 the different self-assembling classes of peptides (e.g., amphipathic, surfactant-like, lipidated, bolamphiphiles, cyclic, and aromatic), the low molecular-weight Fmoc-FF (N αfluorenylmethoxycarbonyl-diphenylalanine) homodimer is one of the most studied [23,24]. The interest around this hydrogelator arises thanks to its ability to gel under physiological conditions of pH and ionic strength [25].…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Peptide-Based Hydrogels Containing Chemical Functional Groups as Innovative Platforms for Biotechnological Applications

Giordano,

Gallo,

Diaferia

et al. 2023

Gels

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Multicomponent hydrogels (HGs) based on ultrashort aromatic peptides have been exploited as biocompatible matrices for tissue engineering applications, the delivery of therapeutic and diagnostic agents, and the development of biosensors. Due to its capability to gel under physiological conditions of pH and ionic strength, the low molecular-weight Fmoc-FF (Nα-fluorenylmethoxycarbonyl-diphenylalanine) homodimer is one of the most studied hydrogelators. The introduction into the Fmoc-FF hydrogel of additional molecules like protein, organic compounds, or other peptide sequences often allows the generation of novel hydrogels with improved mechanical and functional properties. In this perspective, here we studied a library of novel multicomponent Fmoc-FF based hydrogels doped with different amounts of the tripeptide Fmoc-FFX (in which X= Cys, Ser, or Thr). The insertion of these tripeptides allows to obtain hydrogels functionalized with thiol or alcohol groups that can be used for their chemical post-derivatization with bioactive molecules of interest like diagnostic or biosensing agents. These novel multicomponent hydrogels share a similar peptide organization in their supramolecular matrix. The hydrogels’ biocompatibility, and their propensity to support adhesion, proliferation, and even cell differentiation, assessed in vitro on fibroblast cell lines, allows us to conclude that the hybrid hydrogels are not toxic and can potentially act as a scaffold and support for cell culture growth.

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Section: Introductionmentioning

confidence: 99%

Multicomponent Peptide-Based Hydrogels Containing Chemical Functional Groups as Innovative Platforms for Biotechnological Applications

Giordano,

Gallo,

Diaferia

et al. 2023

Gels

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Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform

Yu¹,

Xu²,

Dong³

et al. 2015

CPD

123

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Molecular hydrogels have been widely explored in various biomedical applications, such as cell culture, tissue engineering and drug delivery. Peptide-based hydrogel nanoparticles represent a promising alternative to current drug delivery approaches and cell carriers for tissue engineering, due to their encapsulation stability, water solubility and biocompatibility. This review focuses on recent advances in the use of self-assembling peptide nanogels for applications in drug delivery. We firstly introduce a self-assembly mechanism for small molecules used in the peptide hydrogel, and then describe recent methods for controlling the assembly of molecular hydrogelations. A particular emphasis is placed on recent advances in the use of different types of peptide hydrogels as drug delivery carriers. Lastly, the current challenges and future perspectives for self-assembling peptide hydrogels in drug delivery applications are discussed.

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Progress in Self-assembling Peptide-based Nanomaterials for Biomedical Applications

Huang²,

Li³

et al. 2015

CTMC

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Self-assembled peptide nanomaterials display the advantageous properties of injectability, biodegradability and biocompatibility. These peptide nanomaterials, by self-assembling, can be widely applied in such fields as drug delivery (small molecules and large molecules), regenerative medicine and nanobiotechnology. In this review, we mainly discuss the properties of these peptide nanomaterials in their physical, chemical and biological aspects. Also discussed are recent advances in their potential applications as drug delivery systems and for uses in regenerative medicine. These current advances show a bright future for the development and clinical applications of self-assembled peptide-based nanotechnology and nanomedicine. However, there are still some big challenges for us to face before these peptide nanomaterials eventually can be used for the treatment of human diseases.

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Inside Front Cover: Rigid, Self‐Assembled Hydrogel Composed of a Modified Aromatic Dipeptide (Adv. Mater. 11/2006)

Cited by 3 publications

References 0 publications

Multicomponent Peptide-Based Hydrogels Containing Chemical Functional Groups as Innovative Platforms for Biotechnological Applications

Multicomponent Peptide-Based Hydrogels Containing Chemical Functional Groups as Innovative Platforms for Biotechnological Applications

Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform

Progress in Self-assembling Peptide-based Nanomaterials for Biomedical Applications

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