Insidious onset of Pisa syndrome after rasagiline therapy in a patient with Parkinson’s disease

Valentino, Francesca; Cosentino, Giuseppe; Fierro, Brigida; Realmuto, Sabrina; Mastrilli, Sergio; Savettieri, Giovanni; D’Amelio, Marco

doi:10.1007/s10072-014-1806-5

Cited by 6 publications

(3 citation statements)

References 5 publications

(8 reference statements)

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“…Regarding exposure to dopaminergic drugs, patients with PA were treated first with l ‐dopa and higher LEDD, more often in a combination of l ‐dopa and dopamine agonist, likely because of a more advanced disease stage. Nevertheless, this association did not survive the multivariate logistic regression analysis, which suggests that long‐term treatment with dopaminergic drugs at high dosages is not the only factor that contributes to causing PA despite previous findings for a link between dopaminergic replacement therapy and CC, PS, , and AC …”

Section: Discussioncontrasting

confidence: 64%

Postural Abnormalities in Parkinson's Disease: An Epidemiological and Clinical Multicenter Study

Tinazzi

Gandolfi

Ceravolo

et al. 2019

Movement Disord Clin Pract

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Introduction The overall frequency of postural abnormalities (PA) in Parkinson's disease (PD) is unknown. We evaluated the overall prevalence of PA and assessed the association with demographic and clinical variables. Methods For this multicenter, cross‐sectional study, consecutive PD outpatients attending 7 tertiary Italian centers were enrolled. Patients were evaluated and compared for the presence of isolated PA such as camptocormia, Pisa syndrome, and anterocollis and for combined forms (ie, camptocormia + Pisa syndrome) together with demographic and clinical variables. Results Of the total 811 PD patients enrolled, 174 (21.5%; 95% confidence interval [CI], 18.6%–24.3%) presented PA, 144 of which had isolated PA and 30 had combined PA. The prevalence of camptocormia was 11.2% (95% CI, 9%–13.3%), Pisa syndrome 8% (95% CI, 6.2%–9.9%), and anterocollis 6.5% (95% CI, 4.9%–8.3%). Patients with PA were more often male and older with longer disease duration, more advanced disease stage, more severe PD symptoms, a bradykinetic/rigid phenotype, and poorer quality of life. They were initially treated with levodopa, and more likely to be treated with a combination of levodopa and dopamine agonist, took a higher daily levodopa equivalent daily dose, and had more comorbidities. Falls and back pain were more frequent in PD patients with PA than in those without PA. Multiple logistic regression models confirmed an association between PA and male gender, older age, Hoehn and Yahr stage, and total Unified Parkinson's Disease Rating Scale score. Conclusions PA are frequent and disabling complications in PD, especially in the advanced disease stages.

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Section: Discussioncontrasting

confidence: 64%

Postural Abnormalities in Parkinson's Disease: An Epidemiological and Clinical Multicenter Study

Tinazzi

Gandolfi

Ceravolo

et al. 2019

Movement Disord Clin Pract

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“…We have read with interest comments by Solla et al [1] regarding our Letter to the Editor published in Neurological Sciences titled ''Insidious onset of Pisa Syndrome after rasagiline therapy in a patient with Parkinson's Disease'' [2]. We thank the authors for their interest in our paper, but we think it is necessary to make some clarifications regarding the temporal relationship between the onset of Pisa Syndrome (PS) and rasagiline therapy.…”

Section: Dear Editormentioning

confidence: 93%

Pisa syndrome after rasagiline therapy in a patient with Parkinson’s disease

et al. 2015

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“…Some patients even suffer from a combination of several types of postural abnormalities. Since postural abnormalities in PD subjects usually develop insidiously over months to years before they become obvious 8 , 9 , early recognition of them facilitates the diagnosis of the disease, as well as the prompt intervention to avoid worse outcomes.…”

Section: Introductionmentioning

confidence: 99%

A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients

Hong

Zhang

et al. 2022

npj Parkinsons Dis.

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Postural abnormalities are common disabling motor complications affecting patients with Parkinson’s disease (PD). We proposed a summary index for postural abnormalities (IPA) based on Kinect depth camera and explored the clinical value of this indicator. Seventy individuals with PD and thirty age-matched healthy controls (HCs) were enrolled. All participants were tested using a Kinect-based system with IPA automatically obtained by algorithms. Significant correlations were detected between IPA and the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) total score (rs = 0.369, p = 0.002), MDS-UPDRS-III total score (rs = 0.431, p < 0.001), MDS-UPDRS-III 3.13 score (rs = 0.573, p < 0.001), MDS-UPDRS-III-bradykinesia score (rs = 0.311, p = 0.010), the 39-item Parkinson’s Disease Questionnaire (PDQ-39) (rs = 0.272, p = 0.0027) and the Berg Balance Scale (BBS) score (rs = −0.350, p = 0.006). The optimal cut-off value of IPA for distinguishing PD from HCs was 12.96 with a sensitivity of 97.14%, specificity of 100.00%, area under the curve (AUC) of 0.999 (0.997–1.002, p < 0.001), and adjusted AUC of 0.998 (0.993–1.000, p < 0.001). The optimal cut-off value of IPA for distinguishing between PD with and without postural abnormalities was 20.14 with a sensitivity, specificity, AUC and adjusted AUC of 77.78%, 73.53%, 0.817 (0.720–0.914, p < 0.001), and 0.783 (0.631–0.900, p < 0.001), respectively. IPA was significantly correlated to the clinical manifestations of PD patients, and could reflect the global severity of postural abnormalities in PD with important value in distinguishing PD from HCs and distinguishing PD with postural abnormalities from those without.

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Insidious onset of Pisa syndrome after rasagiline therapy in a patient with Parkinson’s disease

Cited by 6 publications

References 5 publications

Postural Abnormalities in Parkinson's Disease: An Epidemiological and Clinical Multicenter Study

Postural Abnormalities in Parkinson's Disease: An Epidemiological and Clinical Multicenter Study

Pisa syndrome after rasagiline therapy in a patient with Parkinson’s disease

A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients

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