2019
DOI: 10.1016/j.cytogfr.2019.10.003
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Insight into interleukin-37: The potential therapeutic target in allergic diseases

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Cited by 13 publications
(10 citation statements)
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“…Recent studies have reported the significant role of IL-37 in human inflammatory diseases 1013 19. Yang et al demonstrated that IL-37 increases in patients with rheumatoid arthritis and is positively associated with disease progression 20.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent studies have reported the significant role of IL-37 in human inflammatory diseases 1013 19. Yang et al demonstrated that IL-37 increases in patients with rheumatoid arthritis and is positively associated with disease progression 20.…”
Section: Discussionmentioning
confidence: 99%
“…9 Recent studies have reported the significant role of IL-37 in human inflammatory diseases such as chronic periodontitis, lupus erythematosus, allergy, rheumatoid arthritis, Behçet's disease, and acute coronary syndrome. [10][11][12][13][14][15] Based on the above, the aim of this study was to compare the serum levels of IL-37 in patients with CAD compared with the control group, its correlation with serum levels of inflammatory cytokines (IL-6, TNF-α, and IL-32), highsensitivity C reactive protein (hs-CRP), oxidative stress markers (oxidized LDL (ox-LDL), ferric-reducing antioxidant power assay (FRAP), and malondialdehyde (MDA)) as well as ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) gene expression in peripheral blood mononuclear cell (PBMCs) of patients with CAD.…”
Section: Original Researchmentioning
confidence: 99%
“…Intracellularly, IL-37b was cleaved and activated by caspase-1 and formed mothers against decapentaplegic homolog 3 (Smad3) in the nucleus. Extracellularly, IL-37b transduces anti-inflammatory signals by forming IL-37/ IL1R8/IL-18Rα complex [13][14][15]. Several studies demonstrated that IL-37b could downregulate IL-17 and IL-4 secretion by CD4+ T cells through interacting with IL1R8 in AR [16,17].…”
Section: Introductionmentioning
confidence: 99%
“… 27 IL-33 mediates microglia synaptic phagocytosis in central nervous system development. 28 Targeted inhibition of IL-36 signaling is used to treat pustular psoriasis 29 and both IL-37 and IL-38 suppress allergic disease, with the former binding maternal anti-alopecia homolog 3 and entering the nucleus to affect gene transcription, 30 and the latter antagonizing the ERK1/2 and NF-κB pathways and upregulating host defense genes. 31 The interleukin-1 family has been linked to CVD and IL-1α creates a pro-thrombotic microenvironment by inducing IL-6 production while IL-1β drives inflammation during atherosclerosis.…”
Section: Introductionmentioning
confidence: 99%