The amalgamation of microorganisms in the nanofluid is significant in beautifying the thermal conductivity of several systems, such as microfluid devices, chip-shaped microdevices, and enzyme biosensors. The current investigation studies mixed convective flow of the entropy minimization of unsteady MHD tangent hyperbolic nanoliquid because a stretching surface has motile density via convective and slip conditions. For the novelty of this work, the variable transport characteristics caused by dynamic viscosity, thermal conductivity, nanoparticle mass permeability, and microbial organism diffusivity are considered. It is considered that the vertical sheet studying the flow. By using the appropriate alteration, the governing equations for the most recent flow analysis were altered into a non-dimension relation. Through MATLAB Software bvp4c, the PDE model equations have been made for these transformed equations. Engineering-relevant quantities against various physical variables include force friction, Nusselt number, Sherwood number, and microorganism profiles. The results showed good consistency compared to the current literature. Moreover, these outcomes revealed that augmentation in the magnitude of the magnetic field and velocity slip parameter declines the velocity profile. The reverse impact is studied in We. In addition, heat transfer is typically improved by the influence of thermal radiation parameters, Brownian movement, and thermophoretic force. The physical interpretation has existed through graphical and tabular explanations.