Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

Abstract

Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

Multilayered Bio-Based Electrospun Membranes: A Potential Porous Media for Filtration Applications

“…Additionally, specific molecule or ligand immobilization onto the membrane surfaces leads to affinity membranes with selectively captured targeted molecules for use in technologically advanced processes such as membrane filtration and fixed-bed liquid chromatography (Park et al, 2007;Esmaeely Neisiany et al, 2020). This immobilization allows for the purification of molecules according to the differences in biological functions or physical/chemical properties rather than molecular size (Ma et al, 2006).…”

Regeneration of the peripheral nerve via multifunctional electrospun scaffolds

“…Scaffold materials are classified into three general categories: natural, synthetic, and blend. Natural polymers provide specific biochemical signals to enhance cell survival, differentiation, and axonal regeneration due to their high biocompatibility 35,87‐91 . Gelatin is one of the appropriate natural polymers, which have been used in scaffolds due to its integrin‐binding sites for cell adhesion and differentiation 88,92‐94 .…”

The Effect of Carbon Black on the Properties of Plasticised Wheat Gluten Biopolymer

“…The water uptake by the composite samples is presented in Table 7. Numerous factors govern the uptake of water into composite materials [21]. However, in the current composite system, the most likely factors influencing water uptake are the different abilities of the matrix and CB to absorb water, and the capillary action owing to bigger agglomerates at high filler contents [22].…”