Insight into the possible role of miR‐214 in primary osteoporosis via osterix

Abstract

Osteoporosis is a bone disease characterized by chronic pain and recurrent fractures. Osterix is a transcription factor regulating bone formation. miR‐214 was found to have a role in skeletogenesis. Our goal was to investigate the possible role of miR‐214 in primary osteoporosis through osterix. Their expression was determined in bone samples obtained from primary osteoporotic patients (n = 26) and age‐ and sex‐matched controls (n = 14). Additionally, their expression was correlated to the laboratory and clinical parameters of the study participants. Differential expression of osterix and miR‐214 was detected in the osteoporotic group compared to controls. While miR‐214 was significantly higher, osterix was significantly lower. In primary osteoporotic patients, relative quantification value of osterix was positively correlated with sex, body mass index, and ionized calcium and negatively correlated with miR‐214 and C‐reactive protein. Thus, the role of miR‐214 in primary osteoporosis could be through inhibiting osterix expression in bones and therefore both miR‐214 and osterix could be targets for future therapeutic intervention.

Retracted: Long non‐coding RNA MEG3 silencing and microRNA‐214 restoration elevate osteoprotegerin expression to ameliorate osteoporosis by limiting TXNIP

“…There is a study showing that the binding relationship between microRNA (miR)‐214 and lncRNA MEG3 7 . A prior literature has indicated the role of miR‐214 in primary OS via inhibiting osterix expression in bones 8 . It has also been suggested that miR‐214 defends MC3T3‐E1 osteoblasts from H 2 O 2 ‐induced apoptosis by restricting oxidative stress 9 .…”

Immune function of miR-214 and its application prospects as molecular marker

“…According to the research status, miR-214 has promising prospects in the following aspects: Firstly, miR-214 may have in-depth research value in the prevention and treatment of diseases such as organ transplant rejection, autoimmune disease and immune tolerance; Secondly, miR-214 regulates tumor microenvironment to make it have the ability to inhibit the immune escape of tumor cells and its potential application value; Thirdly, abnormal expression of miR-214 can affect the replication of several viruses, which indicates that miR-214 has good development Wu et al (2018a) and Wu et al (2018b) miR-214-3p bone diseases. Up Potential target for the treatment of bone diseases Sun et al (2018) and Mohamad et al (2019) prospect in the diagnosis and treatment of certain viral diseases; Finally, miR-214 has potential application value as a diagnostic marker and therapeutic target in multiple diseases. In short, deep study on the regulatory relationship and molecular regulatory mechanism of miR-214 not only provides important theoretical basis for scientific issues such as immune regulation, tumor treatment, inflammation diagnosis, and antivirus, but also paves the way for actively developing new strategies for the prevention and treatment of these diseases.…”

“…For example, osteoclast-derived exosome miR-214-3p transferred to osteoblasts can inhibit bone formation (Li et al, 2016a;Li et al, 2016b). MiR-214's role in primary osteoporosis may be through inhibiting the expression of osterix to inhibit bone formation (Mohamad et al, 2019). So miR-214 may be an important potential target for the treatment of bone diseases.…”

Human Umbilical Cord Mesenchymal Stem Cell-induced Osterix, Bone Morphogenetic Protein-2, and Tartrate-resistant Acid Phosphatase Expression in Osteoporotic Mandibular Bone

“…17 This finding is in line with those of previous studies, showing that Osx expression in the osteoporosis group was significantly lower than in the normal control groups. 18 BMP-2 works in a matrix and is inactive during the homeostatic phase. The occurrence of defects in the bone triggers remodeling commencing with resorption by osteoclasts, hUCMSC Therapy for Osteoporotic Mandibular Bone Hendrijantini et al…”