Insights from zebrafish on human pigment cell disease and treatment

Cooper, Cynthia D.

doi:10.1002/dvdy.24550

Cited by 38 publications

(20 citation statements)

References 108 publications

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“…Zebrafish are an invaluable model for the study of pigment development and pattern formation due to the wealth of pigment mutants identified during the large-scale mutagenesis screens of the 1990s. 169,170 However, as several recent reviews have already covered this topic in significant depth, [171][172][173] we touch on only a few highlights in the section below.…”

Section: Pigment Cellsmentioning

confidence: 99%

Neural crest development: insights from the zebrafish

Rocha

Singh

Ahsan

et al. 2019

Developmental Dynamics

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Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of multiple model organisms. Early research on neural crest cells (NCCs) was dominated by analyses of accessible amphibian and avian embryos, with mouse genetics providing complementary insights in more recent years. The zebrafish model is a relative newcomer to the field, yet it offers unparalleled advantages for the study of NCCs. Specifically, zebrafish provide powerful genetic and transgenic tools, coupled with rapidly developing transparent embryos that are ideal for high-resolution real-time imaging of the dynamic process of neural crest development. While the broad principles of neural crest development are largely conserved across vertebrate species, there are critical differences in anatomy, morphogenesis, and genetics that must be considered before information from one model is extrapolated to another. Here, our goal is to provide the reader with a helpful primer specific to neural crest development in the zebrafish model. We focus largely on the earliest events-specification, delamination, and migrationdiscussing what is known about zebrafish NCC development and how it differs from NCC development in non-teleost species, as well as highlighting current gaps in knowledge.

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Section: Pigment Cellsmentioning

confidence: 99%

Neural crest development: insights from the zebrafish

Rocha

Singh

Ahsan

et al. 2019

Developmental Dynamics

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“…In other words it may be possible that the 'colossal cell' actually suppresses pigment formation in its vicinity. Such conjectural pigment suppression appears to be unknown in invertebrates, but pigment suppressing agents have been reported in vertebrates, including fish (Cooper 2017;Solano et al 2006).…”

Section: External Featuresmentioning

confidence: 99%

Description and taxonomic analysis of a tuberculated turtle leech from the Outer Banks, North Carolina, USA, provisionally identified as Placobdella multilineata Moore, 1953 (Hirudinea: Glossiphoniidae)

Sawyer¹

2021

Zootaxa

790

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A tuberculated species of turtle leech is indigenous to the Great Dismal Swamp and environs of northeastern North Carolina, and differs from other known species of Placobdella. This study of hundreds of specimens for more than a decade documents its unexpected taxonomic complexity. In fact, this seemingly innocuous leech undergoes radical transformations in terms of morphology and behaviour, each adapted to a different phase of its life cycle. Biological observations reveal a progressive darkening with age which imposes taxonomic uncertainties. Furthermore, some commonly used characters are found to be unsound for taxonomic diagnosis in that they do not occur in all individuals of this species. The primary objective of this paper is a comprehensive description of this Albemarle turtle leech. The question is then asked, what distinguishes it from allied species? Toward this end, a formal taxonomic diagnosis is proposed based on details of the proboscis complex and crop-related tuberculation. This species is allied to the northern P. rugosa (Verrill, 1874) or its southern counterpart P. multilineata Moore, 1953. However, synonymy to either of these forms is problematical due to inadequacy of type descriptions. Nonetheless, in view of habitat similarity the Albemarle leech is provisionally identified as P. multilineata pending comparable studies of variability and development of other tuberculated Placobdella.

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“…The highly similar characteristics of zebrafish and human genes increase the credibility and potential significance of the research results; therefore, the use of zebrafish in the laboratory has increased dramatically in recent years (Howe et al., 2013). Additionally, with the development of research technology such as genetic and gene editing, zebrafish has also become powerful model organism for many different fields of scientific research (Cooper, 2017; Kirchberger et al., 2017; van Rooijen et al., 2017; Tang et al., 2016) and plays an important role in basic research such as evolutionary science, genetics and developmental biology (Broughton et al., 2001; Golling et al., 2002; Hortopan et al., 2010).…”

Section: Introductionmentioning

confidence: 99%

Natural infection of covert mortality nodavirus affects Zebrafish (Danio rerio)

Wang

Liu

Tang

et al. 2021

Journal of Fish Diseases

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Covert mortality nodavirus (CMNV), a novel aquatic pathogen, causes viral covert mortality disease (VCMD) in shrimps and also known to infect farmed marine fish. To date, there has no report regarding the ability of this virus to infect freshwater fish. In this study, we screened and discovered CMNV‐positive freshwater zebrafish individuals by reverse transcription‐nested PCR (RT‐nPCR). The sequence of CMNV amplicons from zebrafish was found to share 99% identity with RNA‐dependent RNA polymerase (RdRp) gene of the original CMNV isolate. Histopathological examination of the CMNV‐positive zebrafish samples revealed extensive vacuolation and karyopyknosis lesions in the retina of the eye and the midbrain mesencephalon. CMNV‐like virus particles were visualized in these tissues under transmission electron microscope. Different degrees of pathological damages were also found in muscle, gills, thymus and ovarian tissues. Strong positive signals of CMNV probe were observed in these infected tissues by in situ hybridization. Overall, all results indicated that zebrafish, an acknowledged model organism, could be infected naturally by CMNV. Thus, it is needed to pay close attention to the possible interference of CMNV whether in assessment of toxic substances, or in studying the developmental characterization and the nerval function, when zebrafish was used as model animal.

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Insights from zebrafish on human pigment cell disease and treatment

Cited by 38 publications

References 108 publications

Neural crest development: insights from the zebrafish

Neural crest development: insights from the zebrafish

Description and taxonomic analysis of a tuberculated turtle leech from the Outer Banks, North Carolina, USA, provisionally identified as Placobdella multilineata Moore, 1953 (Hirudinea: Glossiphoniidae)

Natural infection of covert mortality nodavirus affects Zebrafish (Danio rerio)

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