Insights into fetal death—a patient resource

Smith, Roger; Dedman, Lee; Sultana, Zakia; Banney, David; Maiti, Kaushik

doi:10.1016/j.ajog.2022.02.029

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…Other members will determine whether the necessary staff, medications, and surgical instruments are available as needed. 4,15,16 Even with limited resources, this minimizes intervention during low-risk labor and delivery while focusing on patients in whom more intense scrutiny and care are needed.…”

Section: Maternal Condition Definitionmentioning

confidence: 99%

“…For example, one team member should oversee patient triage/intake, report information to the rest of the team, declare the urgency of the situation, and provide suggestions for further action. Other members will determine whether the necessary staff, medications, and surgical instruments are available as needed 4,15,16 . Even with limited resources, this minimizes intervention during low‐risk labor and delivery while focusing on patients in whom more intense scrutiny and care are needed.…”

Section: Care Coordination Within the Team And Partner Facilities To ...mentioning

confidence: 99%

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Prep‐for‐Labor: Overview ofFIGO's labor and delivery triage bundles of care to optimize maternal and newborn outcomes

Barnea,

Muller,

Di Simone

et al. 2023

Intl J Gynecology & Obste

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Childbirth is an intense event in which decisions may need to be made in seconds to guarantee the health of both mother and newborn. Despite health systems and care approaches varying widely according to real‐life scenarios, availability of facilities, beliefs, resources, staff, and geography, among others, optimal outcomes should be ensured worldwide. Triaging low‐risk pregnancies from high‐risk pregnancies is the first step to ensure proper allocation of resources. From this need, we developed FIGO's Prep‐For‐Labor triage methods, a series of 2‐minute labor and delivery bundles of care, with special regard given to low‐ and middle‐income countries and rural settings. Around 80% of women, once properly triaged, can pursue vaginal delivery with minimal intervention, while those at risk can either be managed on site or transferred promptly to an advanced care site. FIGO's bundles of care and good practice recommendations for labor and delivery and immediate newborn triage cover four clinical scenarios: (1) preterm labor; (2) induced or spontaneous labor at term; (3) cesarean delivery; and (4) newborn care. From rapid triage of the mother (low vs high risk) to the list of required equipment, description of skilled staff, and coordination of resources, the recommendations for care are introduced across these four areas in this overview article. Implementing the proposed management steps described in each summary can improve maternal and neonatal outcomes.

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Section: Maternal Condition Definitionmentioning

confidence: 99%

Section: Care Coordination Within the Team And Partner Facilities To ...mentioning

confidence: 99%

Prep‐for‐Labor: Overview ofFIGO's labor and delivery triage bundles of care to optimize maternal and newborn outcomes

Barnea,

Muller,

Di Simone

et al. 2023

Intl J Gynecology & Obste

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“…Dentro de las causas de muertes fetales se encuentran las complicaciones intrapartos, diabetes, infección, hipertensión, anomalías congénitas, anomalías genéticas y embarazos prolongados (3). Asimismo, el envejecimiento de la placenta juega un rol clave como la principal etiología de las muertes fetales (5). Por otro lado, cabe destacar que existe controversia sobre un mayor riesgo de muerte fetal en gestantes con exposición a partículas finas ambientales (6).…”

Section: Introductionunclassified

“…Docente, Universidad Privada del Norte, Lima, Perú 4. Magister en Educación Superior, Universidad Privada del Norte, Hospital de Vitarte, Lima, Perú 5. Obstetra, Universidad Nacional Mayor de San Marcos, Lima, Perú 6.…”

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Características de los casos de óbito fetal en un hospital público de Perú: estudio descriptivo

Pantigoso-Gutierrez,

Oscátegui-Peña,

Chafloque Chavesta

et al. 2024

RSOGV

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Objective: To describe the characteristics of fetal death cases reported between 2017 and 2021 in a public hospital in Peru. Methods: Descriptive and cross-sectional study, which was conducted in confirmed cases of fetal death in mothers with gestational age greater than 22 weeks presented at the Vitarte Hospital in Lima, Peru. The sample consisted of 137 cases during the period from 2017 to 2021. Frequencies and percentages were presented. Results: Fetal death had a rate of 14,8 per 1000 live births. Most of the women were between 20 and 24 years old (27%), in addition, 70,1% were cohabiting, 92% were housewives and 83,2% studied up to high school. On the other hand, 50,4% were multigestational and 29,9% had a history of abortion and 16,7% had a history of cesarean section. Prenatal service attendance was the most frequent (67,2%) and 29,2% were overweight. Regarding maternal pathologies, 38% had urinary tract infection, 17,5% had preeclampsia without signs of safety and 2,9% had gestational diabetes. Congenital malformations were present in 19% of cases; in addition, 23,4% of fetal deaths had a maternal cause. Conclusions: The rate of fetal death is high. The cases were characterized mostly by mothers with qualities of social vulnerability, in addition to presenting characteristics of higher obstetric risk. Maternal causes of fetal death were the most frequent. Keywords: Fetal death, pregnancy, delivery, risk factors.

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“…Fetal loss, one of the most severe adverse outcomes of pregnancy, can lead to long-lasting grief, guilt, anxiety, self-blame, post-traumatic stress disorder, and marriage breakdown (Robinson, 2014;Smith et al, 2022). The annual prevalence of fetal loss at ≥20 weeks (stillbirth) is estimated at 13.2 and 5.74 per 1,000 births in China and the United States, respectively (Zhu et al, 2021;Gregory et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

CEP55-associated lethal fetal syndrome: a case report of a Chinese family

Wang,

Sheng,

Ying

et al. 2023

Front. Genet.

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Background: Research on fetal loss related to germline mutations in single genes remains limited. Disruption of CEP55 has recently been established in association with perinatal deaths characterized by hydranencephaly, renal dysplasia, oligohydramnios, and characteristic dysmorphisms. We herein present a Chinese family with recurrent fetal losses due to compound heterozygous nonsense CEP55 variants.Case presentations: The Chinese couple had a history of five pregnancies, with four of them proceeding abnormally. Two stillbirths (II:3 and II:4) sequentially occurred in the third and fourth pregnancy. Prenatal ultrasound scans revealed phenotypic similarities between fetuses II:3 and II:4, including oligohydramnios, bilateral renal dysplasia and hydrocephalus/hydranencephaly. Clubfoot and syndactyly were also present in both stillborn babies. Fetus II:3 presented with endocardial cushion defects while fetus II:4 did not. With the product of conception in the fourth pregnancy, whole exome sequencing (WES) on fetus II:4 identified compound heterozygous nonsense CEP55 variants comprised of c.190C>T(p.Arg64*) and c.208A>T(p.Lys70*). Both variants were expected to result in lack of the TSG101 and ALIX binding domain. Sanger sequencing confirmed the presence and cosegregation of both variants.Conclusion: This is the fifth reported family wherein biallelic CEP55 variants lead to multiple perinatal deaths. Our findings, taken together with previously described phenotypically similar cases and even those with a milder and viable phenotype, broaden the genotypic and phenotypic spectrum of CEP55-associated lethal fetal syndrome, highlighting the vital biomolecular function of CEP55.

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Insights into fetal death—a patient resource

Cited by 3 publications

References 19 publications

Prep‐for‐Labor: Overview ofFIGO's labor and delivery triage bundles of care to optimize maternal and newborn outcomes

Prep‐for‐Labor: Overview ofFIGO's labor and delivery triage bundles of care to optimize maternal and newborn outcomes

Características de los casos de óbito fetal en un hospital público de Perú: estudio descriptivo

CEP55-associated lethal fetal syndrome: a case report of a Chinese family

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