Insights into Manganese Superoxide Dismutase and Human Diseases

Liu, Mengfan; Sun, Xuewen; Chen, Boya; Dai, Rongchen; Xi, Zhichao; Xu, Hong‐Xi

doi:10.3390/ijms232415893

Cited by 46 publications

(22 citation statements)

References 242 publications

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“…42 Of particular significance is its role as a catalyst for superoxide dismutase (Mn-SOD) within mitochondria. 43 Taking into consideration the presence of manganese ions in mitochondrial SOD enzyme, we opt for manganese ion coordination with GA.…”

Section: Resultsmentioning

confidence: 99%

“…Manganese stands as a vital trace element essential for the human body, primarily serving as an activator for various enzymes . Of particular significance is its role as a catalyst for superoxide dismutase (Mn-SOD) within mitochondria . Taking into consideration the presence of manganese ions in mitochondrial SOD enzyme, we opt for manganese ion coordination with GA.…”

Section: Resultsmentioning

confidence: 99%

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Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction

Chen,

Qian,

et al. 2024

ACS Nano

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As intervertebral disc degeneration (IVDD) proceeds, the dysfunctional mitochondria disrupt the viability of nucleus pulposus cells, initiating the degradation of the extracellular matrix. To date, there is a lack of effective therapies targeting the mitochondria of nucleus pulposus cells. Here, we synthesized polygallic acid-manganese (PGA-Mn) nanoparticles via self-assembly polymerization of gallic acid in an aqueous medium and introduced a mitochondrial targeting peptide (TP04) onto the nanoparticles using a Schiff base linkage, resulting in PGA-Mn-TP04 nanoparticles. With a size smaller than 50 nm, PGA-Mn-TP04 possesses pH-buffering capacity, avoiding lysosomal confinement and selectively accumulating within mitochondria through electrostatic interactions. The rapid electron exchange between manganese ions and gallic acid enhances the redox capability of PGA-Mn-TP04, effectively reducing mitochondrial damage caused by mitochondrial reactive oxygen species. Moreover, PGA-Mn-TP04 restores mitochondrial function by facilitating the fusion of mitochondria and minimizing their fission, thereby sustaining the vitality of nucleus pulposus cells. In the rat IVDD model, PGA-Mn-TP04 maintained intervertebral disc height and nucleus pulposus tissue hydration. It offers a nonoperative treatment approach for IVDD and other skeletal muscle diseases resulting from mitochondrial dysfunction, presenting an alternative to traditional surgical interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction

Chen,

Qian,

et al. 2024

ACS Nano

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“…Each is produced by distinct genes but catalyzes the same reaction. The mechanism of action of SOD relies on the cycle of the reduction and oxidation states of redox-active transition metals, such as copper and manganese, at the active site of SOD [ 36 , 37 ].

…”

Section: Mechanisms Of Nanozymes For Antioxidant Effectsmentioning

confidence: 99%

Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Thao,

Do,

Nam

et al. 2023

Micromachines

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Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recently, antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes for their stability, cost savings, and flexible design. The present review firstly discusses the mechanisms of antioxidant nanozymes, focusing on catalase-, superoxide dismutase-, and glutathione peroxidase-like activities. Then, we summarize the main strategies for the manipulation of antioxidant nanozymes based on their size, morphology, composition, surface modification, and modification with a metal-organic framework. Furthermore, the applications of antioxidant nanozymes in medicine and healthcare are also discussed as potential biological applications. In brief, this review provides useful information for the further development of antioxidant nanozymes, offering opportunities to improve current limitations and expand the application of antioxidant nanozymes.

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“…They exist in various cells and tissues and are crucial in scavenging free radicals and inhibiting oxidative stress. It has been demonstrated that Mn enhances the activity of MnSOD, which is a major antioxidant enzyme [73]. During chick embryo development, Mn plays an anti-apoptotic role by inhibiting ROS generation and the ERS pathway and increasing MnSOD enzyme activity to alleviate heat stress-induced apoptosis, thereby protecting cardiomyocytes from oxidative stress [74].…”

Section: Zinc Transportersmentioning

confidence: 99%

Metal-Binding Proteins Cross-Linking with Endoplasmic Reticulum Stress in Cardiovascular Diseases

Ding

et al. 2023

JCDD

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The endoplasmic reticulum (ER), an essential organelle in eukaryotic cells, is widely distributed in myocardial cells. The ER is where secreted protein synthesis, folding, post-translational modification, and transport are all carried out. It is also where calcium homeostasis, lipid synthesis, and other processes that are crucial for normal biological cell functioning are regulated. We are concerned that ER stress (ERS) is widespread in various damaged cells. To protect cells’ function, ERS reduces the accumulation of misfolded proteins by activating the unfolded protein response (UPR) pathway in response to numerous stimulating factors, such as ischemia or hypoxia, metabolic disorders, and inflammation. If these stimulatory factors are not eliminated for a long time, resulting in the persistence of the UPR, it will aggravate cell damage through a series of mechanisms. In the cardiovascular system, it will cause related cardiovascular diseases and seriously endanger human health. Furthermore, there has been a growing number of studies on the antioxidative stress role of metal-binding proteins. We observed that a variety of metal-binding proteins can inhibit ERS and, hence, mitigate myocardial damage.

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Insights into Manganese Superoxide Dismutase and Human Diseases

Cited by 46 publications

References 242 publications

Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction

Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction

Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Metal-Binding Proteins Cross-Linking with Endoplasmic Reticulum Stress in Cardiovascular Diseases

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