Insights into the binding of photothermal therapeutic agent bismuth sulfide nanorods with human serum albumin

Selvaraj, N.; Mangalaraja, Ramalinga Viswanathan; Wu, Jerry J.; Asiri, Abdullah M.; Anandan, Sambandam

doi:10.1039/c5ra22641d

Cited by 9 publications

(8 citation statements)

References 41 publications

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“…01-089-8963), indicating high quality of crystallization. The XRD patterns of the BSNRs match with reported values in the literature 30-32. BSNRs present peaks that are assignable to the orthorhombic structure (JCPDS no.…”

Section: Resultssupporting

confidence: 84%

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

et al. 2020

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Human immunodeficiency virus theranostics facilitates the development of long acting (LA) antiretroviral drugs (ARVs) by defining drug-particle cell depots. Optimal drug formulations are made possible based on precise particle composition, structure, shape and size. Through the creation of rod-shaped particles of defined sizes reflective of native LA drugs, theranostic probes can be deployed to measure particle-cell and tissue biodistribution, antiretroviral activities and drug retention.Methods: Herein, we created multimodal rilpivirine (RPV) 177lutetium labeled bismuth sulfide nanorods (177LuBSNRs) then evaluated their structure, morphology, configuration, chemical composition, biological responses and adverse reactions. Particle biodistribution was analyzed by single photon emission computed tomography (SPECT/CT) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging.Results: Nanoformulated RPV and BSNRs-RPV particles showed comparable physicochemical and cell biological properties. Drug-particle pharmacokinetics (PK) and biodistribution in lymphoid tissue macrophages proved equivalent, one with the other. Rapid particle uptake and tissue distribution were observed, without adverse reactions, in primary blood-derived and tissue macrophages. The latter was seen within the marginal zones of spleen.Conclusions: These data, taken together, support the use of 177LuBSNRs as theranostic probes as a rapid assessment tool for PK LA ARV measurements.

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Section: Resultssupporting

confidence: 84%

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

et al. 2020

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“…From the slopes of the linear plots, the Stern–Volmer quenching constants ( K SV ) were calculated as 1.15 × 10 5 L·mol –1 for triangular gold nanoprism and 1.34 × 10 5 L.mol –1 for gold nanodecahedra. The bimolecular quenching rate constants, k q , of triangular gold nanoprism and gold nanodecahedra are found to be 1.15 × 10 13 L·mol –1 s –1 and 1.34 × 10 13 L·mol –1 ·s –1 , respectively, which are greater than that of scatter procedure (2 × 10 10 L·mol –1 ·s –1 ) . This shows that the quenching mentioned above is not initiated by dynamic collision but from the ground state complex formation or static quenching.…”

Section: Resultsmentioning

confidence: 83%

Gold Triangular Nanoprisms and Nanodecahedra: Synthesis and Interaction Studies with Luminol toward Biosensor Applications

Selvaraj

Mangalaraja

et al. 2016

Langmuir

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Gold triangular nanoprisms and nanodecahedra (pentagonal bipyramids) were synthesized in the absence and presence of nanoseeds by a simple solvothermal synthesis through the reduction of Auric Chloride (HAuCl) with poly(vinylpyrrolidone) (PVP) in N,N-dimethylformamide (DMF), respectively. These gold nanoparticles exhibit two plasmon resonance bands. The interaction of these gold nanoparticles with luminol was investigated using UV-vis and fluorescence spectroscopy since hefty number of environmental and biological sensors are based on the combination of luminol and gold nanoparticles. The gold nanoparticles quenches the fluorescence of luminol through a static quenching mechanism, i.e., ground state complex formation, which was confirmed by both absorption spectroscopy as well as time-resolved fluorescence spectroscopy. The Stern-Volmer quenching constant and the effective quenching constant determine that gold nanodecahedra has more interaction with luminol than that of triangular gold nanoprisms. The distance between the gold nanoparticles and luminol, calculated using FRET theory, is less than 8 nm, which indicates efficient energy transfer during interaction. These results are expected to be useful for the development of novel sensors.

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“…K SV decreased gradually with increasing temperature. Thus, quenching follows a static mechanism based on complex formation …”

Section: Resultsmentioning

confidence: 99%

“…[27][28][29] based on complex formation. [30][31][32] Fluorescence lifetime measurements can distinguish static quenching from dynamic quenching. The formation of static ground-state complexes does not decrease the decay time of uncomplexed fluorophores.…”

Section: Fluorescence Quenching Measurementsmentioning

confidence: 99%

“…Displacement experiments were performed using warfarin, ibuprofen, and dansylsarcosine as probes to determine the main MET binding sites according to the method presented by Sudlow et al [31,40] The excitation at 320 nm was used to study single, binary, and ternary systems comprising warfarin, MET (or ibuprofen), and HSA. Accordingly, only warfarin exhibited fluorescence ( Figure 3A).…”

Section: Determination Of the Main Met Binding Site That Binds To Hsamentioning

confidence: 99%

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The binding properties of metandienone and human serum albumin by comparing with other five similar compounds

Lin

Wang

Peng

et al. 2016

J Biochem & Molecular Tox

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Metandienone (MET) is an exogenous anabolic androgenic steroid. The interaction between MET and human serum albumin (HSA) was investigated by molecular modeling and different optical techniques. There was no possibility of energy transfer, and the fluorescence quenching of HSA induced by MET was mainly due to the complex formation. The differences of binding ability between MET and compounds 1-5 were significantly caused by space steric hindrance. The single crystallographic data of two steroids (compounds 4 and 5) were obtained in the methanol at the first time. In addition, the binding ability was slightly affected by -OH, -CH , and -COCH . The results of displacement experiment demonstrated that the MET binding site was mainly located in site 1 of HSA. H-bonding and van der Waals forces were significant in the MET-HSA binding. MET played an insignificant role on the local conformation change in HSA.

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Insights into the binding of photothermal therapeutic agent bismuth sulfide nanorods with human serum albumin

Abstract: The interaction of microwave synthesized bismuth sulfide nanorods with human serum albumin was investigated using multispectroscopic techniques such as absorption spectroscopy, fluorescence spectroscopy and circular dichroism spectroscopy.

Cited by 9 publications

References 41 publications

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

Gold Triangular Nanoprisms and Nanodecahedra: Synthesis and Interaction Studies with Luminol toward Biosensor Applications

The binding properties of metandienone and human serum albumin by comparing with other five similar compounds

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