Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo, Yanxian; Li, Yang; Zhang, Wolun; Zu, Hongru; Yu, Hongfeng; Li, Dongling; Xiong, Honglian; Hormel, Tristan T.; Hu, Chaofan; Guo, Zhouyi; Liu, Zhiming

doi:10.1007/s40843-019-1272-0

Cited by 19 publications

(18 citation statements)

References 48 publications

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“…S23) of mice treated with different groups (PBS and MoO 3−x @PPSNs) after laser irradiation showed that no evident damage was observed at the tumor site of the mouse treated with PBS plus NIR irradiation, while apparent eschar appeared at the tumor region of the mouse treated with MoO 3−x @PPSNs plus NIR irradiation. This can be attributed to the high temperature-induced damage of the tumor and skin tissues, which is consistent with the previous reports [50][51][52]. In addition, all animals survived during the whole treatment process (Fig.…”

Section: In Vivo Anti-tumor Efficacysupporting

confidence: 92%

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

et al. 2021

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Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein, we have developed an "in-situ confined oxidation-reduction" strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor (designated as MoO 3−x @PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in nearinfrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO 3−x @PPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO 3−x NPs in a biocompatible porous silica nanoreactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.

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Section: In Vivo Anti-tumor Efficacysupporting

confidence: 92%

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

et al. 2021

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“…Metal sulfide and oxide materials have attracted wide attention because of their special properties such as free electron transfer characteristics, magnetism ( Gao et al, 2017 ), structure, and photothermal stability ( Dahoumane et al, 2016 ; Ge et al, 2016 ; Vena et al, 2016 ; Guo et al, 2020 ). The unique vacancy structure of copper sulfide, and the LSPR caused by the conduction electron resonance oscillation provide possibility for the study of PTT in NIR-II.…”

Section: Nir-ii Absorbing Materialsmentioning

confidence: 99%

“… Liu et al (2020b) synthesized chitosan (CS) coated RuO 2 NPs (CS-RuO 2 NPs) with a one-pot method, which has unique potential in low-temperature PTT. Guo et al (2020) synthesized MoO 2 nano-aggregates by hydrothermal synthesis. It has strong cell penetration at 1,064 nm.…”

Section: Nir-ii Absorbing Materialsmentioning

confidence: 99%

“…The key to the applications of the NIR-II absorption materials in PTT is that the materials should have good photothermal conversion efficiency, low biological toxicity and easy functionalization. Studies show that Au nanomaterials ( Deng et al, 2019 ; Song et al, 2019 ; Wang et al, 2020c ; Jia et al, 2020 ), metal sulfur oxides ( Lin et al, 2020a ; Sun et al, 2021 ) such as Ag 2 S ( Yang et al, 2017b ) and MoO 2 ( Guo et al, 2020 ), two-dimensional nanomaterials such as MoS 2 ( Shi et al, 2020 ), niobium carbide (MXene) ( Lin et al, 2017b ) and SnTe ( Zhang et al, 2019a ), and polymers ( Sun et al, 2019a ) such as semiconductor polymer nanoparticles SPN 1 ( Jiang et al, 2018b ), SPN 2 ( Yin et al, 2020 ), SPN 3 ( Cao et al, 2018b ) can be applied for NIR-II PTT. By modifying the photothermal materials, researchers can improve their photostability, chemical stability, biocompatibility, and endow them with some new functions, such as targeting and drug delivery.…”

Section: Introductionmentioning

confidence: 99%

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Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

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“…Tri-therapeutic strategies have successfully eliminated tumors both in vitro and in vivo (Curcio et al, 2019 ). Similarly, other MNPs, including Mo, Pd, Pt, Mn, and Bi nanoparticles, have been extensively investigated as excellent phototherapy and imaging agents, which can be used in clinical studies based on their biocompatible behaviors (Badrigilan et al, 2020 ; Guo et al, 2020b ; Jiang et al, 2020 ; Qian et al, 2020 ).…”

Section: Application Of Stimuli-triggered Metallic Nanotherapeutics Imentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such as chemotherapy, radiotherapy, and surgical intervention. Notably, the advantage of nanotherapeutics is mainly attributable to their accumulation and targeting ability toward cancer cells, multiple drug-carrying abilities, combined therapies, and imaging approaches. To date, numerous nanoparticle formulations have been developed for anticancer therapy and among them, metallic nanotherapeutics reportedly demonstrate promising cancer therapeutic and diagnostic efficiencies owing to their dense surface functionalization ability, uniform size distribution, and shape-dependent optical responses, easy and cost-effective synthesis procedure, and multiple anti-cancer effects. Metallic nanotherapeutics can remodel the tumor microenvironment by changing unfavorable therapeutic conditions into therapeutically accessible ones with the help of different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, and reactive oxygen species. The combination of metallic nanotherapeutics with both external and internal stimuli can be used to trigger the on-demand release of therapeutic molecules, augmenting the therapeutic efficacies of anticancer therapies such as photothermal therapy, photodynamic therapy, magnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and immunotherapy. In this review, we have summarized the role of different metallic nanotherapeutics in anti-cancer therapy, as well as their combinational effects with multiple stimuli for enhanced anticancer therapy.

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Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Cited by 19 publications

References 48 publications

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Recent Progress on NIR-II Photothermal Therapy

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

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