Insights into the fate and removal of antibiotics and antibiotic resistance genes using biological wastewater treatment technology

Zhu, Tingting; Su, Zhongxian; Lai, Wen-xia; Zhang, Yao-bin; Liu, Yiwen

doi:10.1016/j.scitotenv.2021.145906

Cited by 247 publications

(65 citation statements)

References 145 publications

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“…It is worth noting that the maximum bactericidal concentrations (MBCs) are not fixed values. They can be revised, depending on changes in the sensitivity of the microbial population in the activated sludge's biocenosis, which is consistent with previous studies [14,16].…”

Section: Modeling the Effects Of Antibiotics And Surfactants On The Activity Of Bioprocessessupporting

confidence: 88%

“…Thus, it was determined that different ecological and trophic levels of the biocenosis have their own threshold of adaptation to increasing concentrations of antibiotics, which is also important to consider when optimizing the wastewater treatment process. A study by Zhu et al [16] described the effects of antibiotics and antibiotic-resistance genes in biological treatment technologies and combined processes in wastewater treatment plants. Adsorption is the main antibiotic removal mechanism for tetracyclines, fluoroquinolones, and macrolides, while biodegradation is the pathway for antibiotic removal for sulfonamides and β-lactams.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the process of microbial co-metabolism contributes to the biodegradation of antibiotics. Process engineering and continuous monitoring and control of bioremediation parameters, the flexibility of the system to adapt to fluctuations, and capital and operating costs are all important [16].…”

Section: Introductionmentioning

confidence: 99%

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Rationale for the Combined Use of Biological Processes and AOPs in Wastewater Treatment Tasks

et al. 2021

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This paper aims to form a unified concept of the integrated use of different wastewater treatment methods to form a resistant biological treatment stage of technological systems under the influence of such toxic factors as antibiotics and surfactants. The processes of mechanical treatment, ozonation, UV irradiation, and electrolytic anodic oxidation were implemented in an electrotechnological wastewater treatment facility. Wastewater treatment quality was determined by the concentration of nitrogen compounds in aqueous solutions according to the method of Lurie. Biodiagnostics of the investigated activated sludge via surfactant action was carried out at polyethylene oxide concentrations of 10, 30, and 50 mg/dm3. As a result of experiments on wastewater treatment after aquaculture, an improvement in the reduction of pollutants only by the indicator “nitrate concentration” was determined: by 20% after anodic oxidation, and by 15% after photolysis. At almost all surfactant concentrations studied, the activated sludge was not completely recovered, which was expressed in a decrease in its quantity and in the inability to aggregate flakes of activated sludge. The diameter of the growth retardation of the standard disk with antibiotic (amoxiclav) by the accumulative culture of activated sludge was 17.3 ± 2 mm at a concentration of 4 mg/dm3 and 31.3 ± 3 mm at a concentration of 6 mg/dm3. In the process of studying the state of the activated sludge’s biocenosis under the influence of such toxicants, several regularities were revealed. The directions of using combined approaches of water treatment and wastewater treatment were defined. The structural model of treatment facilities using aerobic and anaerobic bioprocesses together with advanced oxidative technologies was substantiated.

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Section: Modeling the Effects Of Antibiotics And Surfactants On The Activity Of Bioprocessessupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Rationale for the Combined Use of Biological Processes and AOPs in Wastewater Treatment Tasks

et al. 2021

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“…We will in the last part of section four of this review go through the current knowledge of how effective the different sludge treatment methods are able in reducing ARB and ARGs. This review will present the major groups of antibiotics, the major groups of mechanisms for antibiotic resistance in bacteria, and the general bacterial mechanisms for genetic exchange, but only briefly as other reviews already have covered this in general (Wright, 2010(Wright, , 2011Pazda et al, 2019;Zhu et al, 2021) and in the context of wastewater treatment. More space is instead given to go through what is known about which wastewater sources show the high occurrence of antibiotic resistance, how antibiotic resistance persists and spreads through WWTPs, and what contributes to this persistence.…”

Section: Introductionmentioning

confidence: 99%

A Review on Occurrence and Spread of Antibiotic Resistance in Wastewaters and in Wastewater Treatment Plants: Mechanisms and Perspectives

et al. 2021

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This paper reviews current knowledge on sources, spread and removal mechanisms of antibiotic resistance genes (ARGs) in microbial communities of wastewaters, treatment plants and downstream recipients. Antibiotic is the most important tool to cure bacterial infections in humans and animals. The over- and misuse of antibiotics have played a major role in the development, spread, and prevalence of antibiotic resistance (AR) in the microbiomes of humans and animals, and microbial ecosystems worldwide. AR can be transferred and spread amongst bacteria via intra- and interspecies horizontal gene transfer (HGT). Wastewater treatment plants (WWTPs) receive wastewater containing an enormous variety of pollutants, including antibiotics, and chemicals from different sources. They contain large and diverse communities of microorganisms and provide a favorable environment for the spread and reproduction of AR. Existing WWTPs are not designed to remove micropollutants, antibiotic resistant bacteria (ARB) and ARGs, which therefore remain present in the effluent. Studies have shown that raw and treated wastewaters carry a higher amount of ARB in comparison to surface water, and such reports have led to further studies on more advanced treatment processes. This review summarizes what is known about AR removal efficiencies of different wastewater treatment methods, and it shows the variations among different methods. Results vary, but the trend is that conventional activated sludge treatment, with aerobic and/or anaerobic reactors alone or in series, followed by advanced post treatment methods like UV, ozonation, and oxidation removes considerably more ARGs and ARB than activated sludge treatment alone. In addition to AR levels in treated wastewater, it examines AR levels in biosolids, settled by-product from wastewater treatment, and discusses AR removal efficiency of different biosolids treatment procedures. Finally, it puts forward key-points and suggestions for dealing with and preventing further increase of AR in WWTPs and other aquatic environments, together with a discussion on the use of mathematical models to quantify and simulate the spread of ARGs in WWTPs. Mathematical models already play a role in the analysis and development of WWTPs, but they do not consider AR and challenges remain before models can be used to reliably study the dynamics and reduction of AR in such systems.

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“…Antibiotics are usually removed from aqueous solutions by such processes as biological treatment or adsorption [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Elimination of Antibiotics by Photocatalytic Methods

Kutuzova

Dontsova

Davydova

2021

WPT STN

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Antibiotics have been found in water bodies of different origin around the world, including natural waters. The presence of antibiotics in natural waters is already an important environmental problem, as they pose a potential threat to the environment. Analysis of the literature shows that photocatalytic methods are considered to be more promising than biological methods and adsorption processes for the treatment of water bodies contaminated with antibiotics and other pharmaceuticals. The aim of this study was to determine the efficiency of antibiotics removal (ciprofloxacin, sulfamethoxazole and trimethoprim) by photocatalytic methods over TiO2 photocatalyst modified with yttrium oxide. For this purpose, a commercial sample of TiO2 P25 (Evonik) was modified, which was further characterized by X-ray diffraction and X-ray fluorescence analysis methods. The obtained data indicate the presence of yttrium in commercial P25 sample after modification. Studies on the removal of antibiotics from aqueous solutions by photocatalytic methods were carried out in three ways: employing modified photocatalyst; combination of photocatalyst and hydrogen peroxide, and the combination of photocatalyst with hydrogen peroxide and ozone. The results of research demonstrate high efficiency of photocatalytic methods in the oxidation of antibiotics in aqueous solutions, among which the greatest oxidation is achieved using the combination of heterogeneous photocatalyst, hydrogen peroxide and ozone.

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Insights into the fate and removal of antibiotics and antibiotic resistance genes using biological wastewater treatment technology

Cited by 247 publications

References 145 publications

Rationale for the Combined Use of Biological Processes and AOPs in Wastewater Treatment Tasks

Rationale for the Combined Use of Biological Processes and AOPs in Wastewater Treatment Tasks

A Review on Occurrence and Spread of Antibiotic Resistance in Wastewaters and in Wastewater Treatment Plants: Mechanisms and Perspectives

Elimination of Antibiotics by Photocatalytic Methods

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