Insights into the mechanisms of chitosan–anionic polymers-based matrix tablets for extended drug release

Li, Liang; Wang, Linlin; Li, Jinfeng; Jiang, Shan; Wang, Yitong; Zhang, Xin; Ding, Jiaojiao; Yu, Tongya; Mao, Shirui

doi:10.1016/j.ijpharm.2014.09.057

Cited by 61 publications

(33 citation statements)

References 52 publications

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“…Interactions between Ch amino groups and X carboxyl groups also result in the formation of PECs, which are already used for the immobilization of enzymes and probiotic bacteria and to produce microspheres, tablets, microcapsules, membranes, controlled release systems, and scaffolds for regenerative medicine applications …”

Section: Introductionmentioning

confidence: 99%

Polysaccharide‐based membranes loaded with erythromycin for application as wound dressings

Souza

Moraes

2016

J of Applied Polymer Sci

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In this study, the antibiotic erythromycin (Ery) was incorporated into chitosan (Ch)-alginate (A) and Ch-xanthan (X) membranes with the aim of using them as bioactive wound dressings. Drug incorporation was performed by direct addition (DA) to the polysaccharide mixture and by membrane impregnation in solution (IS). A higher incorporation efficiency was obtained for DA, but higher amounts of drug were loaded into membranes by the IS method (maxima % 2.1 and 0.7 g/g for Ch-X and Ch-A, respectively) because the initial concentration of drug could be higher than that in the DA method. Ery release in phosphate-buffered saline was slow, reaching about 12 and 32 mg of drug/g of membrane in 60 h for Ch-X and 4 and 16 mg/g for Ch-A by the DA and IS methods, respectively. With formulations prepared with IS, the required therapeutic dosage was reached within 60 h, whereas for those incorporating the drug by DA, prolonged use would be required. Both membrane types behaved as drug reservoirs, providing continuous antibiotic release to the wound site. Formulations with higher drug contents showed effective antibacterial activity against two species of bacteria commonly found in skin lesions, Staphylococcus aureus and Pseudomonas aeruginosa, and were thus potentially capable of protecting the wound site from bacterial attack.Erythromycin (Ery) is a medium-spectrum antibiotic of the macrolide family and is produced by Streptomyces erythreus. 6 Susceptible microorganisms include aerobic Gram-positive bacteria, Gram-negative cocci, spirochetes, actinomycetes, rickettsia, Chlamydia trachomatis, Mycoplasma pneumoniae, Legionella pneumophila, nontuberculous mycobacteria, and some anaerobic bacteria. 7 This antibiotic consists of a 13-carbon ring with two sugars attached by glycosidic linkages 8,9 (Figure 1) and has a molecular weight of 733.9 Da. It is slightly soluble in water and very soluble in organic solvents such as ethanol 10 ; it is useful in the therapy of pneumonia, diphtheria, whooping cough, urethritis, and erythrasma and acne treatments. 7 For topical administration, the common dosage is 20 mg/g of vehicle. 11The incorporation of Ery into wound dressings is of interest if prolonged protection and drug delivery are simultaneously desired, mostly for extensive and painful lesions of difficult manipulation. These systems show improved therapy efficiency by means of an appropriate release profile; this leads to drug availability at the wound site for long periods and, thereby, reduces the need for repeated administrations. 12The main purpose of using a wound dressing is to provide a suitable environment at the wound site so that healing is fast

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Section: Introductionmentioning

confidence: 99%

Polysaccharide‐based membranes loaded with erythromycin for application as wound dressings

Souza

Moraes

2016

J of Applied Polymer Sci

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“…In the paper of Li et al, mechanisms of chitosan and anionic polymers combination for extending drug release were extensively explored (Li et al 2014). For example, chitosan-alginate based matrix tablets can be converted into film coated tablets in gastrointestinal environment due to formation of chitosan-alginate complex on the tablet surface, which can better control drug release.…”

Section: As Matrix Of Sustained Release Tabletsmentioning

confidence: 99%

“…For instance, chitosan based dosage forms, such as nanoparticles, microparticles, in situ hydrogels and sustained release systems have been successfully used for the formulation design of water soluble drugs, poorly water soluble drugs, genes and proteins. The release behavior of water soluble drugs can be altered by using chitosan hydrogels, chitosan matrix which can form sustained gel layer (Li et al , 2014Bhattarai et al 2010;Le Tien et al 2003). The dissolution rate and solubility of poorly water soluble drugs can be increased by using chitosan based nano-carriers and chitosan stabilized nanosuspensions (Sun et al 2012;Quan et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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“…The cationic nature of CS results in electrostatic interactions between the positively charged CS and negatively charged mucosal surfaces, and thus promotes transmucosal drugs absorption via a transient widening of the tight junctions between epithelial cells (Fernández-Urrusuno et al, 1999). Therefore, this excellent material has been applied in many fields, particularly in medicine and pharmacy for the development of sustained or controlled-release drug delivery systems (Nunthanid et al, 2004;Reverchon and Antonacci, 2007;Li et al, 2014), and was included in the United States Pharmacopoeia in 2011.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Theophylline-Chitosan Composite Particles Prepared Using Supercritical Assisted Atomization

Chen

Lee

2019

Braz. J. Chem. Eng.

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This study investigated the formation of composite particles of chitosan (CS) and theophylline (TPH) via supercritical assisted atomization (SAA) using aqueous ethanol (50%, v/v) as the solvent and supercritical CO 2 as the spraying medium. According to XRD, DSC, and FTIR analyses, the crystal form of the SAA-treated TPH from the as-received TPH was unchanged. The effect of different mass ratios of CS to TPH on the in vitro release of TPH showed that the dissolution of the highly water-soluble TPH was retarded when included in the composite particles and could be controlled by the mass ratio of the component in the SAA process. The in vitro dissolution data showed a good fit with the Peppas-Sahlin model, which was used to conclude that the drug release from the composite particles resulted from a combination of drug diffusion and relaxation of the polymer. As the mass ratio of CS to TPH increased, the mechanism relating to polymer relaxation became crucial in the TPH-CS composite particles.

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Insights into the mechanisms of chitosan–anionic polymers-based matrix tablets for extended drug release

Cited by 61 publications

References 52 publications

Polysaccharide‐based membranes loaded with erythromycin for application as wound dressings

Polysaccharide‐based membranes loaded with erythromycin for application as wound dressings

Drug Delivery Applications of Chitosan and its Derivatives

Controlled Release of Theophylline-Chitosan Composite Particles Prepared Using Supercritical Assisted Atomization

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