Insights into the Role of the Habenular Circadian Clock in Addiction

Salaberry, Nora L.; Mendoza, Jorge

doi:10.3389/fpsyt.2015.00179

Cited by 18 publications

(13 citation statements)

References 107 publications

(128 reference statements)

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“…It has been previously shown that the geniculohypothalamic tract (which includes the IGL), actively modulates SCN responses to retinal input (Hanna et al 2017) and might modulate metabolic signals to the SCN (Saderi et al 2013), and reward and metabolic signals of feeding to the LHb (Huang et al 2019). Also, it is widely known that the LH and the LHb are deeply involved in the control of metabolism, food intake and motivational processes Salaberry and Mendoza 2016), which could explain our findings in this study.…”

Section: Groupssupporting

confidence: 64%

Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex‐dependent manner

2019

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In our modern society, the exposure to light at night (LAN) has increased considerably, which may impact human health negatively. Especially exposure to light at night containing short wavelength emissions (~450–500 nm) can disrupt the normal function of the biological clock, altering sleep‐wake cycles and inducing metabolic changes. Recently, we reported that light at night acutely impairs glucose tolerance in nocturnal rats. However, light at night in nocturnal rodents coincides with their activity period, in contrast to artificial light at night exposure in humans. The aim of this study was to evaluate the acute effects of blue (λ = 490 ± 20 nm) artificial light at night (bALAN) on glucose metabolism and food intake in both male and female diurnal Sudanian grass rats (Arvicanthis ansorgei) fed either regular chow or a free choice high‐fat high sucrose diet (HFHS). In both chow and HFHS fed male Arvicanthis, 1‐hour of bALAN exposure induced a higher glucose response in the oral glucose tolerance test (OGTT) accompanied by a significant decrease in plasma insulin. Furthermore, in HFHS fed animals, bALAN induced an increase in sucrose intake during the dark phase in males but not in females. Additionally, 1‐h of bALAN increased the nonfasted glucose levels together with plasma corticosterone in female grass rats. These results provide new and further evidence for the deleterious effects of exposure to short wavelength emission‐containing artificial light at night on glucose metabolism in a diurnal rodent in a sex‐dependent manner.

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Section: Groupssupporting

confidence: 64%

Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex‐dependent manner

2019

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“…The habenula constitutes-together with the stria medullaris and pineal gland-the epithalamus and consists of medial and lateral parts [8]. The habenula has received much attention because of it asymmetry in certain vertebrate species [9] and its role in mediating biorhythms [10]. The habenula regulates the intensity of reward-seeking and misery-fleeing behaviour probably in all our vertebrate ancestors.…”

Section: Introductionmentioning

confidence: 99%

Circuits Regulating Pleasure and Happiness: A Focus on Addiction, Beyond the Ventral Striatum

Loonen¹,

Schellekens²,

Ivanova³

2016

Recent Advances in Drug Addiction Research and Clinical Applications

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A recently developed anatomical model describes how the intensity of reward-seeking and misery-fleeing behaviours is regulated. The first type of behaviours is regulated within an extrapyramidal cortical subcortical circuit containing as first relay stations, the caudate nucleus, putamen and core of the accumbens nucleus. The second type of behaviours is controlled by a limbic cortical subcortical circuit with as first stations, the centromedial amygdala, extended amygdala, bed nucleus of the stria terminalis and shell of the accumbens nucleus. We hypothesize that sudden cessation of hyperactivity of the first circuit results in feelings of pleasure and of the second circuit in feelings of happiness. The insular cortex has probably an essential role in the perception of these and other emotions. Motivation to show these behaviours is regulated by monoaminergic neurons projecting to the accumbens from the midbrain dopaminergic ventral tegmental nuclei, adrenergic locus coeruleus and serotonergic upper raphe nuclei. The activity of these monoaminergic nuclei is in turn regulated through a ventral pathway by the prefrontal cortex and through a dorsal pathway by the medial and lateral habenula. The habenula has this role since the first vertebrate human ancestors with a brain comparable to that of modern lampreys. The lateral habenula promotes or inhibits reward-seeking behaviours depending upon the gained reward being larger or smaller than expected. It is suggested that the ventral pathway is essential for maintaining addiction based on the observation of specific cues, while the dorsal pathway is essential for becoming addicted and relapsing during periods of abstinence.

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“…It receives projections from retinal ganglion cells and is involved in reward processing for relevant control of monoaminergic system in the VTA (for DA) and raphe nuclei (for 5-HT) (Hattar et al 2006;Baker and Mizumori 2017). Moreover, the LHb possess oscillating properties which coordinate with the SCN to control circadian rest/activity rhythms (Mendoza 2017;Salaberry and Mendoza 2015), and short brief light pulses at the early night in Arvicanthis niloticus, but not in mice, increase c-Fos expression in the LHb (Shuboni et al 2015). As intermediary structures it is necessary to elucidate the respective contribution of the direct or indirect pathway of the modulation of mood by light.…”

Section: Discussionmentioning

confidence: 99%

Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod

et al. 2018

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Seasonal affective disorder (SAD), beyond mood changes, is characterized by alterations in daily rhythms of behavior and physiology. The pathophysiological conditions of SAD involve changes in day length and its first-line treatment is bright light therapy. Animal models using nocturnal rodents have been studied to elucidate the neurobiological mechanisms of depression, but might be ill suited to study the therapeutic effects of light in SAD since they exhibit light-aversive responses. Here Arvicanthis ansorgei, a diurnal rodent, was used to determine behavioral, molecular and brain dopamine changes in response to exposure to a winter-like photoperiod consisting of a light-dark cycle with 8 h of light, under diminished light intensity, and 16 h of darkness. Furthermore, we evaluated whether timed-daily bright light exposure has an effect on behavior and brain physiology of winter-like exposed animals. Arvicanthis under a winter-like condition showed alterations in the synchronization of the locomotor activity rhythm to the light-dark cycle. Moreover, alterations in day-night activity of dopaminergic neurotransmission were revealed in the nucleus accumbens and the dorsal striatum, and in the day-night clock gene expression in the suprachiasmatic nucleus. Interestingly, whereas dopamine disturbances were reversed in animals exposed to daily light at early or late day, altered phase of the daily rhythm of locomotion was reverted only in animals exposed to light at the late day. Moreover, Per2 gene expression in the SCN was also affected by light exposure at late day in winter-like exposed animals. These findings suggest that light induces effects on behavior by mechanisms that rely on both circadian and rhythm-independent pathways influencing the dopaminergic circuitry. This last point might be crucial for understanding the mechanisms of non-pharmacological treatment in SAD.

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Insights into the Role of the Habenular Circadian Clock in Addiction

Cited by 18 publications

References 107 publications

Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex‐dependent manner

Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex‐dependent manner

Circuits Regulating Pleasure and Happiness: A Focus on Addiction, Beyond the Ventral Striatum

Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod

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