Insights into the <scp>U1</scp> small nuclear ribonucleoprotein complex superfamily

Guiro, Joana; O’Reilly, Dawn

doi:10.1002/wrna.1257

Cited by 35 publications

(36 citation statements)

References 123 publications

(148 reference statements)

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“…The metazoan U1 snRNP, for instance, binds not only to the 5ʹss, but also throughout the nascent transcript, blocking a premature cleavage and polyadenylation (Kaida et al, 2010;Berg et al, 2012). Furthermore, the U1 snRNP is important in regulating promoter directionality and transcription in animals (Almada et al, 2013;Guiro and O'Reilly, 2015).…”

Section: Introductionmentioning

confidence: 99%

The U1 snRNP Subunit LUC7 Modulates Plant Development and Stress Responses via Regulation of Alternative Splicing

et al. 2018

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Section: Introductionmentioning

confidence: 99%

The U1 snRNP Subunit LUC7 Modulates Plant Development and Stress Responses via Regulation of Alternative Splicing

et al. 2018

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“…U1 small nuclear RNA (U1 snRNA) is one of the most abundant noncoding RNA [1]. U1 snRNA has a length of 164 nt in human and its protein binding sites are highly conserved in insects and mammals [2].…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling reveals U1 snRNA regulates cancer gene expression

Cheng

Sun

Niu

et al. 2017

Preprint

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U1 small nuclear RNA (U1 snRNA), as one of the most abundant noncoding RNA in eukaryotic cells plays an important role in splicing of pre-mRNAs. Compared to other studies which have focused on the primary function of U1 snRNA and the neurodegenerative diseases caused by the abnormalities of U1 snRNA, this study is to investigate how the U1 snRNA over-expression affects the expression of genes on a genome-wide scale. In this study, we built a model of U1 snRNA over-expression in a rat cell line. By comparing the gene expression profiles of U1 snRNA over-expressed cells with those of their controls using the microarray experiments, 916 genes or loci were identified significantly differentially expressed. These 595 up-regulated genes and 321 down-regulated genes were further analyzed using the annotations from the GO terms and the KEGG database. As a result, three of 12 enriched pathways are well-known cancer pathways, while nine of them were associated to cancers in previous studies. The further analysis of 73 genes involved in 12 pathways suggests that U1 snRNA regulates cancer gene expression. The microarray data with ID GSE84304 is available in the NCBI GEO database.

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“…Since the onset of transcriptomics, it has become increasingly evident that non-coding RNAs are key regulators of these processes (1). The pol II-transcribed Uridyl-rich small nuclear (Usn)RNA, U1, in the form of a ribonucleoprotein (RNP) complex, plays a pivotal role in regulating RNA isoform production via intimate interactions with the nascent RNA and two major RNA processing machineries, the Spliceosome and Polyadenylation Complex (2–5). The 5′ end of U1 base-pairs with complementary sequences throughout the pre-mRNA to recruit the Spliceosome to exon/intron junctions and to inhibit cleavage and polyadenylation at internal cryptic poly A (pA) sites (6–8).…”

Section: Introductionmentioning

confidence: 99%

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease

et al. 2016

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The U1 small nuclear (sn)RNA (U1) is a multifunctional ncRNA, known for its pivotal role in pre-mRNA splicing and regulation of RNA 3′ end processing events. We recently demonstrated that a new class of human U1-like snRNAs, the variant (v)U1 snRNAs (vU1s), also participate in pre-mRNA processing events. In this study, we show that several human vU1 genes are specifically upregulated in stem cells and participate in the regulation of cell fate decisions. Significantly, ectopic expression of vU1 genes in human skin fibroblasts leads to increases in levels of key pluripotent stem cell mRNA markers, including NANOG and SOX2. These results reveal an important role for vU1s in the control of key regulatory networks orchestrating the transitions between stem cell maintenance and differentiation. Moreover, vU1 expression varies inversely with U1 expression during differentiation and cell re-programming and this pattern of expression is specifically de-regulated in iPSC-derived motor neurons from Spinal Muscular Atrophy (SMA) type 1 patient's. Accordingly, we suggest that an imbalance in the vU1/U1 ratio, rather than an overall reduction in Uridyl-rich (U)-snRNAs, may contribute to the specific neuromuscular disease phenotype associated with SMA.

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Insights into the U1 small nuclear ribonucleoprotein complex superfamily

Cited by 35 publications

References 123 publications

The U1 snRNP Subunit LUC7 Modulates Plant Development and Stress Responses via Regulation of Alternative Splicing

The U1 snRNP Subunit LUC7 Modulates Plant Development and Stress Responses via Regulation of Alternative Splicing

Gene expression profiling reveals U1 snRNA regulates cancer gene expression

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease

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