Insights on luminescence quenching of ZnO tetrapods in the detection of hCG

ZnO Transducers for Photoluminescence-Based Biosensors: A Review

“…where I UV 0 stands for the integrated intensity of the NBE for the blank/reference (without any analyte) and I UV Analyte corresponds to the integrated intensity of the same emission after analyte immobilization for each concentration C [9,107]. Therefore, the data demonstrated that the developed biosensor can be employed in hCG quantification, presenting fairly results in the range between 5 and 50 ng mL −1 [9].…”

“…Recently, our research group has also devoted great efforts studying ZnO-based transducers to be explored into optical biosensors [9,107]. In 2020, we investigated a PLbased immunosensor for the detection of the human chorionic gonadotropin (hCG) hor- In 2021, Myndrul et al [106] used polyacrylonitrile (PAN)/ZnO nanofibres as the transducer integrated into a microfluidic cell to detect Aflatoxin B1 (AFB1), which is a toxin with a harmful effect in human health.…”

“…Recently, our research group has also devoted great efforts studying ZnO-based transducers to be explored into optical biosensors [9,107]. In 2020, we investigated a PL-based immunosensor for the detection of the human chorionic gonadotropin (hCG) hormone [9]. In this case, the anti-hCG AB were physically adsorbed onto ZnO tetrapods produced by LAFD.…”

“…Furthermore, biosensors find applications ranging from health, environmental, food and water monitoring to biosafety [1][2][3][4]. Since the first report on a glucose biosensor, which dates from the 1960s [5,6], countless efforts have been devoted to this topic and new works reporting the use of novel materials and/or transduction approaches are published daily [7][8][9][10][11][12]. This research was further boosted by the recent health crisis with the COVID-19 pandemic, which strongly increased the awareness of the population to the need for reliable solutions for a prompt diagnosis [13,14].…”

“…Since PL signals are very sensitive to small modifications in the materials' surface, it is a powerful method to assess surface phenomena and evaluate the reactions that occur at the interface between the transducer and the bioreceptor when the biorecognition events take place, thus providing high sensitivity and specificity to sensors based on such signal [2]. Consequently, the use of the luminescence features of ZnO as an alternative transduction approach is being exploited in this field [2,9,34,35,42,[48][49][50][51][52][53], in particular for direct detection, where the signal provided by the transducer is the one that is used for sensing, without the need of additional probes or tags [2]. As a number of relevant works were conducted more recently than the above-mentioned review, the present paper intends to fill that lack of compiled information on this specific topic.…”