Insomnia: prevalence and its impact on excessive daytime sleepiness and psychological well-being in the adult Taiwanese population

Kao, Ching Chiu; Huang, Chun Jen; Wang, Mei Yeh; Tsai, Pei‐Shan

doi:10.1007/s11136-008-9383-9

Cited by 81 publications

(62 citation statements)

References 18 publications

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“…Etwa in der japanischen Bevölkerung beträgt der Kurzschläferan-teil nur 4% (resp. : 3,2% Langschläfer) [5], in der taiwanesischen Bevölkerung lediglich 3,2% (zu lange Schlafdauer wurde hier nicht berichtet) [26].…”

Section: Schlafdauerunclassified

“…Die Prävalenz in der deutschen Erwachsenenbevölkerung ist damit annähernd gleich hoch wie bei erwachsenen Personen in anderen Ländern [5,26]. Die Häufigkeit des Schlafmittelkonsums lag in der deutschen Erwachsenenbevölkerung bei insgesamt 5,7% und damit -trotz einer deutlich höheren Prä-valenz von Ein-und Durchschlafstörun-gen -vergleichbar hoch wie beispielsweise in der spanischen Bevölkerung mit 5,5% [27].…”

Section: Schlafqualität Und Schlafmittelkonsumunclassified

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Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Schlack

Hapke

Maske

et al. 2013

Bundesgesundheitsbl.

179

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Section: Schlafdauerunclassified

Section: Schlafqualität Und Schlafmittelkonsumunclassified

Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Schlack

Hapke

Maske

et al. 2013

Bundesgesundheitsbl.

179

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“…[1][2][3] In Taiwan, a study examining the prevalence rate of insomnia found that over 25% of Taiwanese adults experienced insomnia. 4 In Hong Kong, 39.4% of the adult population (equivalent to 2.2 million) are affected by insomnia. 5 It is recognized that, left untreated, transient insomnia can evolve to a chronic condition.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of a Novel Zolpidem Nasal Spray for Rapid Management of Insomnia: First Trial in Humans

Wang³

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: The present single-dose, parallel-group, randomized, double-blind, placebo-controlled study is to evaluate the pharmacokinetics, tolerability and safety of zolpidem tartrate nasal spray (ZNS) as compared to placebo in healthy subjects. Methods: Thirty-six healthy subjects participated in this study, with 19 male and 17 female subjects in 3 cohorts (12 subjects per cohort), who were randomly assigned to receive either an intranasal dose of ZNS 1.75 mg, 3.5 mg, 5.0 mg (n = 10 per dose), or an intranasal placebo (n = 2). Multiple venous blood samples were collected for pharmacokinetic analyses. Results: Plasma zolpidem concentrations rapidly increased after intranasal ZNS 1.75, 3.5, and 5.0 mg with mean T max of 0.42, 0.76 and 0.50 h, respectively, followed by rapid decreases at all three doses. C max , AUC 0-t , and AUC 0-∞ were found to increase in a dose-proportional manner. Female subjects had generally higher AUC 0-t , AUC 0-∞ , and lower weight-normalized clearance rate (CL/F) than male subjects. In this study, ZNS was safe and well tolerated over the evaluated dose range. There were no serious adverse events. Conclusions: Zolpidem was rapidly absorbed and eliminated after intranasal administration of ZNS. Dose proportionality was found at the doses ranged from 1.75 mg to 5.0 mg. Intranasal exposure of zolpidem was generally higher in female subjects than that in male subjects. It could be concluded that ZNS is safe and well tolerated over the evaluated range of intranasal doses. Keywords: insomnia, middle-of-the-night awakening, hypnotics, pharmacokinetics, drug metabolism Citation: Li CT, Su TP, Wang Y, Lee B, Toh M, Ho T. Pharmacokinetics of a novel zolpidem nasal spray for rapid management of insomnia: first trial in humans.

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“…One-third of adults in the United States report inadequate sleep [2], and more than 25% of Taiwanese adults experience insomnia [3]. Sleep insufficiency can cause accidents; affect relationships and mental prowess; and have detrimental effects on health outcomes, such as increasing the risk for cardiovascular disease (CVD), type 2 diabetes mellitus (DM), obesity, cancer, depression, and total mortality [2,4].…”

Section: Introductionmentioning

confidence: 99%

Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders

Lai

Lin

et al. 2013

Sleep Medicine

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Insomnia: prevalence and its impact on excessive daytime sleepiness and psychological well-being in the adult Taiwanese population

Abstract: Taiwanese adults had a high prevalence of insomnia. Insomnia contributed at least partially to an individual's psychological well-being.

Cited by 81 publications

References 18 publications

Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Häufigkeit und Verteilung von Schlafproblemen und Insomnie in der deutschen Erwachsenenbevölkerung

Pharmacokinetics of a Novel Zolpidem Nasal Spray for Rapid Management of Insomnia: First Trial in Humans

Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders

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