Instant Protection Spray for Anti‐Infection and Accelerated Healing of Empyrosis

Abstract

Distinct from common injuries, deep burns often require a chronic recovery cycle for healing and long‐term antibiotic treatment to prevent infection. The presence of drug‐resistant bacteria has caused antibiotics to no longer be perfect, and continuous drug use can easily lead to repeated infection and even death. Inspired by how wild animals chew plants to prevent wound infection, probiotic extracts with a structure similar to the tailspike of phage were obtained from L. casei and combined with different flavones to design a series of nonantibiotic bactericides. These novel antibacterial agents were combined with a rapid gelation spray with a novel cross‐angle layout to form an instant protection spray (IPS) and provide a physical and anti‐infectious barrier for burns within 30 s. This IPS was able to sterilize 100.00% and 96.14% of multidrug‐resistant Staphylococcus aureus (MRSA) in vitro and in vivo, respectively. In addition, it was found to effectively reduce inflammation in MRSA‐infected burns in rats and promote tissue healing.This article is protected by copyright. All rights reserved

Heme-Mimetic Photosensitizer with Iron-Targeting and Internalizing Properties for Enhancing PDT Activity and Promoting Infected Diabetic Wound Healing

“…TCPP has been reported to produce ROS to kill bacteria through PDT effects. 22 We analyzed the MIC value of Fe-TCPP against E. coli, MRSA, and S. aureus after a 10 min exposure to NIR and by measuring bacterial turbidity at 600 nm after a 12-h incubation. The MIC of E. coli (Figure S10A−C), S. aureus (Figure S10D−F), and MRSA (Figure S10G−I) was 200, 20, and 50 μg/mL, respectively.…”

“…20,21 Porphyrin as the photosensitizer can be excited at a specific wavelength and generate large amounts of ROS such as hydroxyl radical (•OH) and singlet oxygen ( 1 O 2 ), which then attack various biological molecules in bacterial cells to efficiently eradicate bacteria. 22 Therefore, this can be used as an effective pathway to deliver PSs into bacteria by inducing the bacteria to uptake iron heme−mimetic materials.…”

Breaking Iron Homeostasis: Iron Capturing Nanocomposites for Combating Bacterial Biofilm

“…Additionally, TCPP has been demonstrated to be a promising template for preparing photo-responsive twodimensional metal-organic frameworks (MOFs) that exhibit excellent photothermal and photodynamic properties. [17] Therefore, TCPP-based two-dimensional MOFs can accelerate photo-triggered ion release, [18] potentially achieving efficient Ga 3 + /Fe 3 + ion exchange.…”

Spatiotemporally Controllable Bifunctional Micellar-Carbon Dot Supernanoparticles for Wounds Healing

“…The indiscriminate use of antibiotics contributes to a relentless surge in bacterial resistance, potentially pushing humanity into a scenario where “no drugs are available”, thereby intensifying the challenges of treating infected wounds. − Antibacterial photodynamic therapy (aPDT) has garnered increasing attention as a light-controllable, rapid, efficient, noninvasive, and broad-spectrum antimicrobial strategy for addressing infected wounds. ,− In the aPDT process, photosensitizers activated by specific wavelengths swiftly produce a multitude of reactive oxygen species (ROS), − capable of directly impairing bacterial cell walls, membranes, lipids, and nucleic acids, thereby accomplishing antimicrobial effects. ,− This antibiotic-free therapy notably mitigates the likelihood of antibiotic-resistant bacteria. ,, However, despite the potent bactericidal efficacy demonstrated by aPDT through the induction of ROS generation, its side effect of localized ROS overdose, resulting in increased inflammation and tissue damage, has not been adequately addressed. , …”