Instructive electroactive electrospun silk fibroin-based biomaterials for peripheral nerve tissue engineering

Phamornnak, Chinnawich; Han, Bing; Spencer, Ben F.; Ashton, Mark; Blanford, Christopher F.; Hardy, John G.; Blaker, Jonny J.; Cartmell, Sarah H.

doi:10.1016/j.bioadv.2022.213094

Cited by 15 publications

(6 citation statements)

References 82 publications

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“…Another hybrid NGC is the combination of SF with PEDOT:PSS to create a two-layer structure, of which the inner layer contained aligned electrospun SF and the outer layer comprised random electrospun SF, with an integrated network of self-assembled PEDOT:PSS throughout both layers for electrical conductivity. In vitro testing demonstrated that adding PEDOT:PSS to create a hybrid NGC did not affect biocompatibility but improved neurite outgrowth when compared to SF-only NGCs [ 77 ].…”

Section: Design Considerations For Biomimetic Nerve Guidance Conduitsmentioning

confidence: 99%

Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration

Mankavi,

Ibrahim,

Wang

2023

Nanomaterials

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Injuries to the peripheral nervous system are a common clinical issue, causing dysfunctions of the motor and sensory systems. Surgical interventions such as nerve autografting are necessary to repair damaged nerves. Even with autografting, i.e., the gold standard, malfunctioning and mismatches between the injured and donor nerves often lead to unwanted failure. Thus, there is an urgent need for a new intervention in clinical practice to achieve full functional recovery. Nerve guidance conduits (NGCs), providing physicochemical cues to guide neural regeneration, have great potential for the clinical regeneration of peripheral nerves. Typically, NGCs are tubular structures with various configurations to create a microenvironment that induces the oriented and accelerated growth of axons and promotes neuron cell migration and tissue maturation within the injured tissue. Once the native neural environment is better understood, ideal NGCs should maximally recapitulate those key physiological attributes for better neural regeneration. Indeed, NGC design has evolved from solely physical guidance to biochemical stimulation. NGC fabrication requires fundamental considerations of distinct nerve structures, the associated extracellular compositions (extracellular matrices, growth factors, and cytokines), cellular components, and advanced fabrication technologies that can mimic the structure and morphology of native extracellular matrices. Thus, this review mainly summarizes the recent advances in the state-of-the-art NGCs in terms of biomaterial innovations, structural design, and advanced fabrication technologies and provides an in-depth discussion of cellular responses (adhesion, spreading, and alignment) to such biomimetic cues for neural regeneration and repair.

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Section: Design Considerations For Biomimetic Nerve Guidance Conduitsmentioning

confidence: 99%

Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration

Mankavi,

Ibrahim,

Wang

2023

Nanomaterials

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“…Based on these properties, the drug release characteristics could be predicted, and the drug dosage could be adjusted in time (Gharehnazifam et al, 2021). The mechanical properties of the electrospinning SF mats were improved after wetting, which was more suitable to be used as drug carrier (Phamornnak et al, 2022). The electrospinning SF mat has good physical properties and can be used as neural substrates to promote the growth of neurons (Nune et al, 2019).…”

Section: Different Forms Of Silk Fibroin Carrier For Drug Deliverymentioning

confidence: 99%

Silk fibroin carriers with sustained release capacity for treating neurological diseases

Huang

Yuan

et al. 2023

Front. Pharmacol.

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Neurological diseases such as traumatic brain injury, cerebral ischemia, Parkinson’s, and Alzheimer’s disease usually occur in the central and peripheral nervous system and result in nervous dysfunction, such as cognitive impairment and motor dysfunction. Long-term clinical intervention is necessary for neurological diseases where neural stem cell transplantation has made substantial progress. However, many risks remain for cell therapy, such as puncture bleeding, postoperative infection, low transplantation success rate, and tumor formation. Sustained drug delivery, which aims to maintain the desired steady-state drug concentrations in plasma or local injection sites, is considered as a feasible option to help overcome side effects and improve the therapeutic efficiency of drugs on neurological diseases. Natural polymers such as silk fibroin have excellent biocompatibility, which can be prepared for various end-use material formats, such as microsphere, gel, coating/film, scaffold/conduit, microneedle, and enables the dynamic release of loaded drugs to achieve a desired therapeutic response. Sustained-release drug delivery systems are based on the mechanism of diffusion and degradation by altering the structures of silk fibroin and drugs, factors, and cells, which can induce nerve recovery and restore the function of the nervous system in a slow and persistent manner. Based on these desirable properties of silk fibroin as a carrier with sustained-release capacity, this paper discusses the role of various forms of silk fibroin-based drug delivery materials in treating neurological diseases in recent years.

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“…On this evidence, electroconductive conduits have been investigated [ [21] , [22] , [23] , [24] ] that can support an electrical environment of artificially generated electric fields necessary for efficient nerve regeneration. For example, Phamornnak et al [ 25 ] have developed electroactive microfibrous scaffolds based on silk fibroin (SF) and poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) for peripheral neural tissue engineering. The latest developments in the field of conductive NGCs have been systematically summarized in a review paper [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Shlapakova,

Surmeneva,

Kholkin

et al. 2024

Materials Today Bio

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Instructive electroactive electrospun silk fibroin-based biomaterials for peripheral nerve tissue engineering

Cited by 15 publications

References 82 publications

Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration

Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration

Silk fibroin carriers with sustained release capacity for treating neurological diseases

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

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