Instrumental characterization of the smectite clay–gentamicin hybrids

Rapacz-Kmita, Alicja; Stodolak-Zych, Ewa; Ziąbka, Magdalena; Różycka, Agnieszka; Dudek, Magdalena

doi:10.1007/s12034-015-0943-7

Cited by 33 publications

(22 citation statements)

References 38 publications

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“…After gentamicin incorporation in HAP/CS/Gr/Gent coating, a new band at 1640 cm −1 appeared (Figure 1f). This band can be assigned to the N‐H bending vibration of primary aromatic amines (Rapacz‐Kmita, Stodolak‐Zych, Ziabka, Rozycka, & Dudek, 2015), confirming gentamicin presence in composite coatings. Additional confirmation of the gentamicin interaction with apatite and chitosan can be obtained in the FTIR spectra through the shift of the characteristic chitosan bands to the lower wavenumbers.…”

Section: Resultsmentioning

confidence: 91%

Antibacterial graphene‐based hydroxyapatite/chitosan coating with gentamicin for potential applications in bone tissue engineering

Stevanović

Djošić

Janković

et al. 2020

J Biomedical Materials Res

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Electrophoretic deposition process (EPD) was successfully used for obtaining graphene (Gr)‐reinforced composite coating based on hydroxyapatite (HAP), chitosan (CS), and antibiotic gentamicin (Gent), from aqueous suspension. The deposition process was performed as a single step process at a constant voltage (5 V, deposition time 12 min) on pure titanium foils. The influence of graphene was examined through detailed physicochemical and biological characterization. Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis, X‐ray diffraction, Raman, and X‐ray photoelectron analyses confirmed the formation of composite HAP/CS/Gr and HAP/CS/Gr/Gent coatings on Ti. Obtained coatings had porous, uniform, fracture‐free surfaces, suggesting strong interfacial interaction between HAP, CS, and Gr. Large specific area of graphene enabled strong bonding with chitosan, acting as nanofiller throughout the polymer matrix. Gentamicin addition strongly improved the antibacterial activity of HAP/CS/Gr/Gent coating that was confirmed by antibacterial activity kinetics in suspension and agar diffusion testing, while results indicated more pronounced antibacterial effect against Staphylococcus aureus (bactericidal, viable cells number reduction >3 logarithmic units) compared to Escherichia coli (bacteriostatic, <3 logarithmic units). MTT assay indicated low cytotoxicity (75% cell viability) against MRC‐5 and L929 (70% cell viability) tested cell lines, indicating good biocompatibility of HAP/CS/Gr/Gent coating. Therefore, electrodeposited HAP/CS/Gr/Gent coating on Ti can be considered as a prospective material for bone tissue engineering as a hard tissue implant.

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Section: Resultsmentioning

confidence: 91%

Antibacterial graphene‐based hydroxyapatite/chitosan coating with gentamicin for potential applications in bone tissue engineering

Stevanović

Djošić

Janković

et al. 2020

J Biomedical Materials Res

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“…When it comes to mechanical properties, nanoclays are more efficient than classical fillers in strengthening the polymer matrices, especially when they are added in small amounts. Volume fractions of the clay fillers as low as 1-3 % can result in tremendous increase in both stiffness and strength while exerting no influence on the overall density of material [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Organophilisation Process on Properties of the Bentonite Filler and Mechanical Properties of the Clay/Epoxy Nanocomposites

Rapacz-Kmita

Moskała

Dudek

et al. 2016

Archives of Metallurgy and Materials

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In this comparative study, the influence of the organophilisation process on the properties of resulting organobentonite fillers and their capability to improve the mechanical properties of clay/polymer nanocomposites were investigated. The organobentonites were obtained by activation with the use of two organic quaternary ammonium salts (QAS) with alkyl chains of significantly different lengths. The organophilisation resulted in an increase in the interlayer space of clays, which was confirmed by XRD analysis. The obtained organofillers were used to produce nanoclay/epoxy resin composites and the effects of alkyl chain length on the resulting properties of composites were compared based on the examination of mechanical behaviour and morphology, and a composite filled with the non organophilised bentonite was used as a reference material. It was demonstrated that the organophilisation process using distearyldimethyl ammonium chloride salt with a longer alkyl chain (C18-C20) created a more superior conditions for the compatibility of nanofiller with a polymer matrix, resulting in a 25 % increase in the bending strength of the epoxy composite material filled with 3 %wt of the organophilised bentonite, comparing to neat epoxy.

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“…The most promising nanofillers acting as water storage materials in this case are clays: montmorillonite (MMT), bentonite, and kaolinite [13][14][15]. On the other hand, the use of the same nanoscale clay fillers in small amounts of minimal wt% may also accelerate the degradation time of PCNs [16,17], which is desirable from the point of view of numerous applications, such as waste management and biomedical applications, where controlling of the degradation time is very often critical.…”

Section: Introductionmentioning

confidence: 99%

Effect of clay mineral on the accelerated hydrolytic degradation of polylactide in the polymer/clay nanocomposites

et al. 2015

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Instrumental characterization of the smectite clay–gentamicin hybrids

Cited by 33 publications

References 38 publications

Antibacterial graphene‐based hydroxyapatite/chitosan coating with gentamicin for potential applications in bone tissue engineering

Antibacterial graphene‐based hydroxyapatite/chitosan coating with gentamicin for potential applications in bone tissue engineering

Influence of the Organophilisation Process on Properties of the Bentonite Filler and Mechanical Properties of the Clay/Epoxy Nanocomposites

Effect of clay mineral on the accelerated hydrolytic degradation of polylactide in the polymer/clay nanocomposites

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