2018
DOI: 10.1002/jbm.a.36337
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Instrumented indentation for determination of mechanical properties of human cornea after ultraviolet‐A crosslinking

Abstract: UVA crosslinking is used for treatment of corneal diseases such as keratoconus in order to stabilize the corneal tissue by crosslinking of the collagen fibers. It has been shown that the crosslinking treatment leads to a stiffening of the central corneal tissue. However, knowledge of lateral extent of the corneal stiffening as well as a systematic study of the mechanical response of human cornea is still missing. In our study we measured the stiffness (elastic modulus) of the anterior surface of healthy and cr… Show more

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Cited by 19 publications
(20 citation statements)
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“…During the unloading phase, the force was reduced at a rate of 0.30 mN/min. In accordance with previous studies, 39–41 a Hertz fit to the loading portion of the indentation curve was used to calculate the Young modulus. The contact point of the NI tip and the corneal probe detected by the NI device was individually reviewed and if necessary manually corrected.…”
Section: Methodsmentioning
confidence: 99%
“…During the unloading phase, the force was reduced at a rate of 0.30 mN/min. In accordance with previous studies, 39–41 a Hertz fit to the loading portion of the indentation curve was used to calculate the Young modulus. The contact point of the NI tip and the corneal probe detected by the NI device was individually reviewed and if necessary manually corrected.…”
Section: Methodsmentioning
confidence: 99%
“…performed as published earlier 58 . In brief, the tissue was immersed in a medium containing 15% dextran for 24 h to achieve dehydration similar to the situation in vivo.…”
Section: Elastic Modulus Determination By Instrumented Indentation Bmentioning
confidence: 99%
“…Biomechanical characterization was performed as published earlier 58 . In brief, the tissue was immersed in a medium containing 15 % dextran for 24 hours to achieve dehydration similar to the situation in vivo.…”
Section: Elastic Modulus Determination By Instrumented Indentationmentioning
confidence: 99%