Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis

Belkhiria, Chama; Vergara, Rodrigo C.; Martin, Simon S.; Leiva, Alexis; Martínez, Melissa; Marcenaro, Bruno; Andrade, Maricarmen; Délano, Paul H.; Delgado, Carolina

doi:10.3389/fnagi.2020.00102

Cited by 22 publications

(30 citation statements)

References 86 publications

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“…DPOAE were measured at eight different frequencies per ear, between 707 and 3563 Hz. For subsequent analyses we counted the number of detected DPOAE, a value that considering both ears, goes from 0 to 16 (see [9,13] for more details on DPOAE analysis). ABR waveforms were averaged with alternating clicks presented at supra-thresholds levels (2000 repetitions, 80 dB nHL, bandpass 0.1-3 kHz, stimulus rate 21.1 Hz, EP25, Eclipse, Interacous-tics1).…”

Section: Auditory Evaluationsmentioning

confidence: 99%

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Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis

et al. 2020

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Epidemiological evidence shows an association between hearing loss and dementia in elderly people. However, the mechanisms that connect hearing impairments and cognitive decline are still unknown. Here we propose that a suprathreshold auditory-nerve impairment is associated with cognitive decline and brain atrophy. Methods: audiological, neuropsychological, and brain structural 3-Tesla MRI data were obtained from elders with different levels of hearing loss recruited in the ANDES cohort. The amplitude of waves I (auditory nerve) and V (midbrain) from auditory brainstem responses were measured at 80 dB nHL. We also calculated the ratio between wave V and I as a proxy of suprathreshold brainstem function. Results: we included a total of 101 subjects (age: 73.5 ± 5.2 years (mean ± SD), mean education: 9.5 ± 4.2 years, and mean audiogram thresholds (0.5-4 kHz): 25.5 ± 12.0 dB HL). We obtained reliable suprathreshold waves V in all subjects (n = 101), while replicable waves I were obtained in 92 subjects (91.1%). Partial Spearman correlations (corrected by age, gender, education and hearing thresholds) showed that reduced suprathreshold wave I responses were associated with thinner temporal and parietal cortices, and with slower processing speed as evidenced by the Trail-Making Test-A and digit symbol performance. Non-significant correlations were obtained between wave I amplitudes and other cognitive domains. Conclusions: These results evidence that reduced suprathreshold auditory nerve responses in presbycusis are associated with slower processing speed and brain structural changes in temporal and parietal regions.

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Section: Auditory Evaluationsmentioning

confidence: 99%

“…Presbycusis is also associated with executive dysfunction [8,9] and with brain atrophy in the temporal lobe [10,11]. Moreover, recent studies in presbycusis have shown cortical atrophy in regions beyond the auditory cortex, including the cingulate cortex and parietal regions [9,12,13].…”

Section: Introductionmentioning

confidence: 99%

Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis

et al. 2020

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“…They did not have any diagnosed neurological diseases, and were not using hearing aids at enrollment in the study. More details about the inclusion and exclusion criteria can be found in our previous works 25,26 . The study was approved by the Ethical and Scientific Committee of the Clinical Hospital of the University of Chile (HCUCH), permission number OAIC 752/15.…”

Section: Methodsmentioning

confidence: 99%

“…Considering that our study explores audition, and FER we looked for the main cortical and subcortical brain areas responsible of these functions in the literature: (1) temporal cortex, 38 (2) cingulate 26,39 (3) amygdala, 17 and (4) insula 40–42 . Other regions such as hippocampus, thalamus, lingual, fusiform gyrus, and accumbens area were also included because of their early damage in Alzheimer's disease 43 …”

Section: Methodsmentioning

confidence: 99%

Neural links between facial emotion recognition and cognitive impairment in presbycusis

Belkhiria

Vergara

Martínez

et al. 2021

Int J Geriat Psychiatry

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Objectives Facial emotion recognition (FER) is impaired in people with dementia and with severe to profound hearing loss, probably reflecting common neural changes. Here, we aim to study the association between brain structures and FER impairment in mild to moderate age‐related hearing loss participants. Methods We evaluated FER in a cross‐sectional cohort of 111 Chilean nondemented elderly participants. They were assessed for FER in seven different categories using 35 facial stimuli. We collected pure‐tone average (PTA) audiometric thresholds, cognitive and neuropsychiatric assessments, and morphometric brain imaging using a 3‐Tesla MRI. Results According to PTA threshold levels, participants were classified as controls (≤25 dB, n = 56) or presbycusis (>25 dB, n = 55), with an average PTA of 17.08 ± 4.8 dB HL and 36.27 ± 9.5 dB HL respectively. Poorer total FER score was correlated with worse hearing thresholds (r = −0.23, p < 0.05) in participants with presbycusis. Multiple regression models explained 57 % of the variability of FER in presbycusis and 10% in controls. In both groups, the main determinant of FER was cognitive performance. In the brain structure of presbycusis participants, FER was correlated with the atrophy of the right insula, right hippocampus, bilateral cingulate cortex and multiple areas of the temporal cortex. In controls, FER was only associated with bilateral middle temporal cortex volume. Conclusions FER impairment in presbycusis is distinctively associated with atrophy of neural structures engaged in the perceptual and conceptual level of face emotion processing.

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“…Currently, these are powerful tools to objectively assess the degree of hearing loss, cochlear function, and auditory nerve–auditory pathway in patients. A limited number of studies have correlated OAE (Belkhiria et al, 2019 , 2020 ) and ABR (Delano et al, 2020 ) with magnetic resonance imaging (MRI) which is the most commonly used objective measurement tool of cognitive function. Furthermore, electroencephalogram (EEG) technology has become another potential tool to measure cognitive function.…”

Section: Cognitive Screening Tools Overviewmentioning

confidence: 99%

Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review

Tao

Chen

Zheng

et al. 2021

Front. Aging Neurosci.

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Strong links between hearing and cognitive function have been confirmed by a growing number of cross-sectional and longitudinal studies. Seniors with age-related hearing loss (ARHL) have a significantly higher cognitive impairment incidence than those with normal hearing. The correlation mechanism between ARHL and cognitive decline is not fully elucidated to date. However, auditory intervention for patients with ARHL may reduce the risk of cognitive decline, as early cognitive screening may improve related treatment strategies. Currently, clinical audiology examinations rarely include cognitive screening tests, partly due to the lack of objective quantitative indicators with high sensitivity and specificity. Questionnaires are currently widely used as a cognitive screening tool, but the subject’s performance may be negatively affected by hearing loss. Numerous electroencephalogram (EEG) and magnetic resonance imaging (MRI) studies analyzed brain structure and function changes in patients with ARHL. These objective electrophysiological tools can be employed to reveal the association mechanism between auditory and cognitive functions, which may also find biological markers to be more extensively applied in assessing the progression towards cognitive decline and observing the effects of rehabilitation training for patients with ARHL. In this study, we reviewed clinical manifestations, pathological changes, and causes of ARHL and discussed their cognitive function effects. Specifically, we focused on current cognitive screening tools and assessment methods and analyzed their limitations and potential integration.

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Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis

Cited by 22 publications

References 86 publications

Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis

Reduced suprathreshold auditory nerve responses are associated with slower processing speed and thinner temporal and parietal cortex in presbycusis

Neural links between facial emotion recognition and cognitive impairment in presbycusis

Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review

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