Insular carcinoma of the thyroid in a 10-year-old child

Rijhwani, Ashok; Satish, Gayathri

doi:10.1016/s0022-3468(03)00198-2

Cited by 11 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analyzing these features, both focal and predominant IC were more frequent in patients age >45 years, with no difference noted between the 2 groups. This is in agreement with data from the literature that report a higher frequency of insular thyroid tumors in older patients, although cases of patients age <18 years are occasionally reported 21–26. These cases appear to demonstrate a clinical outcome that is poorer than that observed in DTC diagnosed in childhood.…”

Section: Discussionsupporting

confidence: 91%

Thyroid carcinomas with a variable insular component

Rufini

Salvatori

Fadda

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND. An insular growth pattern may be observed focally both in papillary and follicular thyroid carcinoma. The aim of the current study was to determine whether a greater extension of the insular component (IC) influences different clinical and histologic features at diagnosis, and a different tumor aggressiveness in terms of frequency in the occurrence of metastases as well as survival. METHODS. Thirty‐three patients with histopathologic findings consistent with IC were included in the study. IC was focal (<50% of the tumor area) in 16 patients and predominant (>50% of the tumor area) in 17 patients. These 2 groups were compared with a control group of 66 patients with differentiated thyroid carcinoma. RESULTS. At diagnosis, carcinomas with predominant IC differed from those with focal IC with regard to greater tumor size and a higher frequency of extrathyroidal extension and distant metastases. Patient follow‐up ranged from 5 to 188 months. The cumulative rate of distant metastases was significantly higher in patients with predominant IC. At the time of last follow‐up, carcinomas with predominant IC demonstrated a lesser frequency of disease‐free outcome (P = .002) and a higher number of tumor‐related deaths (P = .002), either when distant metastases were present (P = .03) or absent (P = .05) at the time of diagnosis. CONCLUSIONS. The presence of predominant IC is associated with a poor prognosis in terms of ongoing disease or death. Predominant IC should be considered a separate entity from not only the classical papillary or follicular carcinomas but also the focal IC tumor. Cancer 2007. © 2007 American Cancer Society.

show abstract

Section: Discussionsupporting

confidence: 91%

Thyroid carcinomas with a variable insular component

Rufini

Salvatori

Fadda

et al. 2007

Cancer

View full text Add to dashboard Cite

show abstract

“…Thyroid cancer with insular-type components has a worse prognosis in adults [7]. Prognosis of these tumors in childhood is unknown [8,9] 10-year-old girl is presented and therapeutic options and prognosis are discussed.…”

mentioning

confidence: 99%

Insular-type component follicular thyroid carcinoma in a 10-year-old girl—case report

Prommegger

Häussler

Gabriel

et al. 2006

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…In comparison to patients solely with FTC, patients with ITC are older, more often male, have larger tumor sizes, are more likely to experience metastasis, are less likely to have a negative resection margin, and have a significantly lower survival rate (11). Patients with ITC usually complain of the presence of a rapidly growing neck swelling in association with dyspnea, dysphagia and voice hoarseness (12). The case described in the present study was a 52-year-old female with a hard neck mass and normal vocal cords, with no other associated symptoms.…”

Section: Discussionmentioning

confidence: 99%

Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature

Salih,

Abdullah,

Baba

et al. 2024

World Acad Sci J

View full text Add to dashboard Cite

Follicular thyroid carcinoma (FTC) is a well-differentiated malignancy, while insular thyroid carcinoma (ITC) is a very rare and poorly differentiated tumor. The present study reports a case of ITC arising within the background of FTC. A 52-year-old housewife presented with an anterior neck swelling for a duration of 6 months. An ultrasound examination revealed a well-defined solid nodule measuring ~58x37x28 mm in the mid-lower third of the right thyroid lobe, and two small nodules of <3 mm in size in the left lobe. Fine needle aspiration cytology of the lesion led to the suspicion of follicular neoplasm. A right thyroid lobectomy was performed, and the histopathological examination revealed poorly differentiated insular carcinoma arising in the background of FTC. As a result of this diagnosis, a completion thyroidectomy was performed. ITC is a rare and highly aggressive thyroid malignancy that is morphologically and biologically regarded as an intermediate between fully differentiated and undifferentiated/anaplastic thyroid carcinomas. In comparison to patients solely with follicular carcinoma, patients with insular carcinoma are older, more often male, have larger tumor sizes, are at greater risk of metastasis, and have a lower survival rate. Poorly differentiated ITC with follicular carcinoma is a very rare and aggressive condition that could be managed by thyroidectomy followed by radioiodine therapy.

show abstract

Insular carcinoma of the thyroid in a 10-year-old child

Cited by 11 publications

References 8 publications

Thyroid carcinomas with a variable insular component

Thyroid carcinomas with a variable insular component

Insular-type component follicular thyroid carcinoma in a 10-year-old girl—case report

Insular thyroid carcinoma in the background of follicular thyroid carcinoma: A report of a rare case and mini‑review of the literature

Contact Info

Product

Resources

About