Insular epilepsy etiology: clinical manifestation and management tactics for cerebral cavernous angiomas

Background. Neuronal and mixed neuronal-glial tumors are rare brain tumors that are most commonly observed in pediatric patients. The main clinical manifestations are presented by epilepsy substantially affecting child’s physical and neurocognitive development.Objective: to assess short-term and long-term changes in seizure frequency and neurocognitive status in pediatric patients who underwent surgery for mixed neuronal-glial tumors.Material and methods. Thirty-eight pediatric patients underwent surgery for mixed neuronal-glial tumors at the Almazov Research Medical Centre within the period from 2008 to 2018. All patients had comprehensive diagnostic examination including clinical neurological examination, neuroimaging tests, electroencephalography and electrocorticography before and after surgery. The postoperative changes in the seizures rate were assessed by using the 1993, 1996 Engel classification. Neurocognitive status was evaluated using The Child Behavior Checklist (a component of the Achenbach System of Empirically Based Assessment).Results. During the postoperative period, 84% of patients were found to be seizure-free; 42.6% demonstrated no clinically relevant behavioral disturbances or social adaption issues after the surgery. However, 76% of children experienced poor concentration. In a long-term perspective, seizures reoccured in 25% of patients and were not associated with any magnetic resonance signs of tumor progression.Conclusion. A gross total resection of the brain tumor was the main factor that affected changes over time in seizure rate. Assessment of long-term changes over time has shown that the patients tended to retain concentration difficulties, which should be taken into account while planning school education programs.

show abstract

Unsatisfactory results of a drug resistant epilepsy surgical treatment: reasons analysis and treatment optimization way

Одинцова¹,

Aleksandrov²,

Ulitin³

et al. 2018

Transl. med. (Print)

View full text Add to dashboard Cite

The relevance of the studied problem was caused by high prevalence of drug resistant epilepsy, an increased structural epilepsy detection and extension indications for a surgical treatment.The purpose of article consisted in a research of the reasons of low efficiency of epilepsy surgical treatment in adult population with a cross-disciplinary approach position.Material and methods.The leading approach was the retrospective open research of the failure factors at 14 patiens.Results.It was revealed unsatisfactory result of epilepsy surgical treatment was caused by a complex of the reasons. The disease features have been the main reason for a failure in 100% of cases, additional reasons: irrational pharmacotherapy -in 86%, the surgical reasons — in 36% of cases.Conclusions.The unsatisfactory result of epilepsy surgical treatment was caused by a complex of the reasons. Cross-disciplinary approach to a problem, improvement of the epilepsy managment, further researches are required. Materials of article can be useful for the personified approach at surgical treatment of epilepsy.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Insular epilepsy etiology: clinical manifestation and management tactics for cerebral cavernous angiomas

Cited by 4 publications

References 7 publications

Clinical, structural and functional features of paroxismal syndrome in insular and temporal lobe tumors

Clinical, structural and functional features of paroxismal syndrome in insular and temporal lobe tumors

Short-term and long-term changes in seizure frequency and neurocognitive status in pediatric patients after surgery for mixed neuronal-glial brain tumors

Unsatisfactory results of a drug resistant epilepsy surgical treatment: reasons analysis and treatment optimization way

Contact Info

Product

Resources

About