Insular networks for emotional processing and social cognition: Comparison of two case reports with either cortical or subcortical involvement

Heart evoked potential triggers brain responses to natural affective scenes: A preliminary study

“…Our findings may prove relevant to the field of neurocardiology and to models of heart-brain interactions, for both cardiac and psychiatric diseases (Couto et al, 2013b;Critchley and Harrison, 2013;Kemp and Quintana, 2013;Kemp et al, 2010). Also, present results provide a novel approach combining ECG and ERP signals with theoretical implications for the conception of emotions driven by autonomic and bodily sensing.…”

“…The HEP analysis was performed after EEG data preprocessing following previous reports of our group (Couto et al, 2013b;Ibanez et al, 2013). We performed Monte Carlo permutation tests aimed at estimating the null distribution of the test statistics, by generating and analyzing surrogate data that is similar to the original data (Eklund et al, 2011) and compared the experimental conditions of the HEP within five regions of interest (ROIs, see Supplementary data, Section 1.4.1).…”

Social information processing following resection of the insular cortex

“…Examination of the impact of age at seizure onset suggested no influence of this variable on the results. Interestingly, Couto et al (2013) compared two patients who suffered from right-hemispheric focal strokes, one in the insular cortex, and the other with a subcortical stroke damaging the connections of the insula with frontotemporal areas and preserving the insular cortex. In comparison to a matched sample of 10 healthy participants, the patient with subcortical damage, but not the one with isolated insular injury, showed deficits in negative emotion processing and empathy.…”

Integration of Intention and Outcome for Moral Judgment in Frontotemporal Dementia: Brain Structural Signatures

“…This methodology allows comparisons between the scores of each bvFTD patient and those of the control group [38,39]. This modified test is more robust for nonnormal distributions, generates few type I errors [40], and has been employed in recent single-case studies [41,42,43]. Additionally, several reports [41,44,45,46,47] have relied on this method to compare a number of measures and experimental variables of single cases with a control sample, which shows that it is a widely used strategy in the current neuropsychological literature.…”