Insulin and other hypoglycemic drugs

Antidiabetics and antihypertensive medications use in Morocco: A pharmacoepidemiological descriptive study

“…10 The class of biguanides is generally well-tolerated compared to insulin, is inexpensive, acts by decreasing the insulin resistance, inhibits hepatic gluconeogenesis and opposes the action of glucagon. Their preventive actions on the cardiovascular system were confirmed in 53 observational and experimental studies 16 (Hazard ration HR 0.78, 95%, CI 0.73–0.83, p < 0.00001) as compared to the insulin group. Their main adverse reactions include nausea, abdominal discomfort and some diarrhoea.…”

“… 17 Generally, metformin has to be taken with meals in an increasing dose as tolerated. A retrospective cohort study 16 conducted in England and Wales has linked insulin with an increased risk of composite non-fatal acute myocardial infraction, which causes death and non-fatal stroke (HR 2.6, 95%, CI 1.9–3.4). The association of biguanides with insulin 16 was linked to gastroduodenal discomfort, weight loss and hypoglycaemia.…”

“…A retrospective cohort study 16 conducted in England and Wales has linked insulin with an increased risk of composite non-fatal acute myocardial infraction, which causes death and non-fatal stroke (HR 2.6, 95%, CI 1.9–3.4). The association of biguanides with insulin 16 was linked to gastroduodenal discomfort, weight loss and hypoglycaemia. The class of sulfonylureas 17 acts as insulin secretagogues, and as β-cell pancreatic dysfunction progresses, they become less effective.…”