Insulin Increases Reendothelialization and Inhibits Cell Migration and Neointimal Growth After Arterial Injury

Breen, Danna M.; Chan, Kalam K.; Dhaliwall, Jiwanjeet K.; Ward, Michael R.; Koudsi, Nael Al; Lam, Loretta; Souza, Melissa de Carvalho; Ghanim, Husam; Dandona, Paresh; Stewart, Duncan J.; Bendeck, Michelle P.; Giacca, Adria

doi:10.1161/atvbaha.109.185447

Cited by 49 publications

(38 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of insulin for 3 days has been reported to decrease intimal area and increased re-endothelialization after balloon catheter injury in rat arteries, without altering plasma glucose concentrations significantly [56]. These studies support an anti-atherogenic action of insulin, yet care should be taken when assessing studies with systemic, prolonged treatment with insulin which may mimic hyperinsulinemia, with potential detrimental effects on vascular health.…”

mentioning

confidence: 78%

Examining the Role of Insulin in the Regulation of Cardiovascular Health

Salt

2012

Future Cardiol.

View full text Add to dashboard Cite

Examining the role of insulin in the regulation of cardiovascular health SUMMARYA substantial body of evidence has reported insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids. In particular, insulin regulates endothelial synthesis of the vasoactive mediators nitric oxide and endothelin-1, yet the importance of this in the maintenance of cardiovascular health remains poorly understood.Recent studies using animals with targeted downregulation of insulin signaling in vascular tissues are improving our understanding of the role of insulin in vascular health. This article focuses on the direct actions of insulin in cardiovascular tissues, with particular emphasis on the molecular mechanisms of insulin action on endothelial function. The potential contribution of impaired vascular insulin action to the cardiovascular complications of diabetes will also be discussed.

show abstract

mentioning

confidence: 78%

Examining the Role of Insulin in the Regulation of Cardiovascular Health

Salt

2012

Future Cardiol.

View full text Add to dashboard Cite

show abstract

“…In addition, angiotensin II-induced oxidative stress and subsequent EPC dysfunction could be attenuated by treatment with TDZ, resulting in lowered peroxynitrite levels and increased telomerase activity (44). Insulin treatment increases reendothelialization and the number of circulating progenitor cells and inhibits cell migration and neointimal growth after arterial injury (12).…”

Section: Antidiabetics and Organic Nitratesmentioning

confidence: 99%

Critical Role of the Nitric Oxide/Reactive Oxygen Species Balance in Endothelial Progenitor Dysfunction

Fleißner

Thum²

2011

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Endothelial injury and dysfunction are critical events in the pathogenesis of cardiovascular disease. During these processes, an impaired balance of nitric oxide bioavailability and oxidative stress is mechanistically involved. Circulating angiogenic cells (including early and late outgrowth endothelial progenitor cells (EPC)) contribute to formation of new blood vessels, neovascularization, and homeostasis of the vasculature, and are highly sensitive for misbalance between NO and oxidative stress. We here review the role of the endothelial nitric oxide synthase and oxidative stress producing enzyme systems in EPC during cardiovascular disease. We also focus on the underlying molecular mechanisms and potential emerging drug-and gene-based therapeutic strategies to improve EPC function in cardiovascular diseased patients. Antioxid. Redox Signal. 15, 933-948.

show abstract

“…Physiological stimuli of PLD2 can generate CPA in biologically effective concentrations, as indicated by our findings using the foam-cell formation and adipocyte differentiation models in cultured cell lines and also using primary monocytes/macrophages, and PPAR$-dependent vascular remodeling in vivo. In addition, the present data reinforce the long-standing observation that low concentrations of insulin protect against neointimal growth (Breen et al, 2009). …”

Section: Discussionsupporting

confidence: 89%

Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents

Tsukahara¹

View full text Add to dashboard Cite

Insulin Increases Reendothelialization and Inhibits Cell Migration and Neointimal Growth After Arterial Injury

Cited by 49 publications

References 48 publications

Examining the Role of Insulin in the Regulation of Cardiovascular Health

Examining the Role of Insulin in the Regulation of Cardiovascular Health

Critical Role of the Nitric Oxide/Reactive Oxygen Species Balance in Endothelial Progenitor Dysfunction

Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents

Contact Info

Product

Resources

About