Insulin: Inducer of glucose 6-phosphate dehydrogenase

Antihyperglycemic effect of esculetin modulated carbohydrate metabolic enzymes activities in streptozotocin induced diabetic rats

“…This action results in increased production of the reducing agent, NADPH, with a concomitant decrease in oxidative stress (Ugochukwu & Babady, 2002). Insulin is reported to increase the activity of glucose 6-phosphate dehydrogenase in a dose dependent manner (Weber & Convery, 1966). In our study, administration of esculetin increased the activity of glucose 6-phosphate dehydrogenase significantly by enhancing insulin secretion.…”

Factors Influencing Carbohydrate Metabolism in Man

“…It has been shown earlier, both in animal and in man, that glucokinase activity (Salas et al, 1963;Blumenthal et al, 1964: Pilkis, 1968Borrebaek et al, 1970) and glucose-6-phosphate dehydrogenase activity {Weber and Convery, 1966;Rudack et al, 1971) in the liver are decreased by fasting and increased after refeeding with carbohydrate. Glucokinase is increased through de novo synthesis, a process sensitive to insulin.…”

Differential Effects of Glucagon on Induction of Rat Liver GIucose-6-Phosphate Dehydrogenase by Liver Injury and Dietary Change

“…The induction of G6PD by liver injury appeared to be independent of insulin levels [14] in contrast to the dietary induction of G6PD [25]. No insulin requirement for G6PD induction by liver injury prompted us to investigate the effect of another pancreatic hormone, glucagon, on the increase of liver G6PD level in both CCl4-injured and glucose casein-refed rats.…”