Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome

Hutchison, Samantha; Zoungas, Sophia; Teede, Helena

doi:10.5694/j.1326-5377.2007.tb00889.x

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Obesity has a specific impact on women's reproductive health, increasing the prevalence and severity of PCOS, infertility, pregnancy complications, gestational diabetes and fetal pregnancy complications, with substantial and escalating economic costs 33 , 34 . Indeed, the adverse impact of obesity on fertility, exacerbated by delay in childbearing, is resulting in a significant social, health and economic burden in Australia 35 . Given the dramatic increase in obesity, the guideline addresses weight loss and prevention of weight gain through lifestyle intervention (Section 5).…”

Section: Polycystic Ovary Syndrome: An Introductionmentioning

confidence: 99%

Assessment and management of polycystic ovary syndrome: summary of an evidence‐based guideline

Teede

Misso

Deeks

et al. 2011

Medical Journal of Australia

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297

255

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Section: Polycystic Ovary Syndrome: An Introductionmentioning

confidence: 99%

Assessment and management of polycystic ovary syndrome: summary of an evidence‐based guideline

Teede

Misso

Deeks

et al. 2011

Medical Journal of Australia

Self Cite

297

255

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“…The reduction in androgen levels occurs by direct influence on ovarian steroidogenesis through the decrease of insulin levels and increase of SHBG 15 . Treatment of hirsutism with these drugs is still controversial, although studies have shown reduced growth and thickness of hair, and improvement of acne and acanthosis nigricans 15,38,40,41 .…”

Section: Insulin Sensitizersmentioning

confidence: 99%

Síndrome do ovário policístico: abordagem dermatológica

Moura

Costa

Bagatin

et al. 2011

An. Bras. Dermatol.

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Polycystic ovary syndrome (POS) is one of the most common endocrine abnormalities affecting women of reproductive age. It is a cause of significant social embarrassment and emotional distress. The pathogenesis of the disease is not yet fully understood, but it is thought to be a complex multigenic disorder, including abnormalities in the hypothalamic-pituitary axis, steroidogenesis, and insulin resistance. The main diagnostic findings of the syndrome are: hyperandrogenism, chronic anovulation and polycystic ovarian morphology seen on ultrasound. Hyperandrogenism is generally manifested as hirsutism, acne, seborrhea, androgenic alopecia and, in severe cases, signs of virilization. Treatment may improve the clinical manifestations of excess androgen production, normalize menses and ameliorate metabolic syndrome and cardiovascular complications. This article reviews the diagnosis, clinical manifestations, metabolic complications, and treatment of the syndrome. Early diagnosis and the consequent early treatment may prevent metabolic complications and emotional distress that negatively impact the patients' quality of life.

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Obesity, metabolic complications and the menopause: an opportunity for prevention

2010

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The prevalence of obesity is rising dramatically, impacting adversely on health and well-being at the menopause and across the lifespan. With menopause, abdominal adiposity selectively increases. The impact of obesity and abdominal adiposity on chronic disease, including diabetes and cardiovascular disease, is significant and quality of life is adversely affected. Yet accurate perception of the weight-related health-risk profile is lacking and there is inadequate focus on prevention and treatment of obesity and its complications. Research aimed at prevention and management of obesity at menopause is limited. Accurate risk perception, education and translation programs highlighting obesity risks and supporting sustainable lifestyle changes are needed, particularly around menopause.

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Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome

Cited by 3 publications

References 6 publications

Assessment and management of polycystic ovary syndrome: summary of an evidence‐based guideline

Assessment and management of polycystic ovary syndrome: summary of an evidence‐based guideline

Síndrome do ovário policístico: abordagem dermatológica

Obesity, metabolic complications and the menopause: an opportunity for prevention

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