Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry

Abstract

Introduction Data from the “Trattamento Ormonale nello Scompenso CArdiaco” (T.O.S.CA) registry showed that heart failure (HF) represents a complex clinical syndrome with different hormonal alterations. Renal failure represents a frequent complication in HF. We evaluated the relationship between renal function and insuline-like growth factor-1 (IGF-1) deficiency and its impact on cardiovascular mortality (CVM) in patients enrolled in the T.O.S.CA. registry. Methods At the enrolment, all subjects underwent chemistry examinations, including circulating hormones and cardiovascular functional tests. COX regression analysis was used to evaluate factors related to CVM during the follow-up period in all populations, in high-risk patients and in the young-adult population. Also, we evaluate the effects of renal function on the CVM. Results 337 patients (41 deceased) were analyzed. CVM was related to severe renal dysfunction (HR stages IV–V = 4.86), high-risk conditions (HR 2.25), serum IGF-1 (HR 0.42), and HF etiology (HR 5.85 and HR 1.63 for valvular and ischemic etiology, respectively). In high-risk patients, CVM was related to IGF-1 levels, severe renal dysfunction and valvular etiology, whereas in young patients CMV was related to the high-risk pattern and serum IGF-1 levels. Conclusions Our study showed the clinical and prognostic utility of the IGF-1 assay in patients with HF.

Dietary Provision, GLIM-Defined Malnutrition and Their Association with Clinical Outcome: Results from the First Decade of nutritionDay in China

“…Moreover, compared with malnourished patients without dietary provision, malnourished and non-malnourished patients receiving dietary provision had a nearly 1.6 to 1.9 higher chance of achieving a good 30-day outcome, highlighting the potential impacts of dietary provision on in-patients. Notably, observational studies such as the nutritionDay surveys mainly show an association between dietary provision and good 30-day outcomes because some unmeasured factors, such as muscle mass and specific laboratory results [ 35 , 36 , 37 ], may have improved the prognosis of less severely ill patients who could receive dietary provision. Due to the potential prevention and treatment of dietary interventions on chronic diseases [ 11 , 12 , 13 , 14 ], hospital staff should take into account the impact of nutrition provision throughout medical care [ 38 , 39 ] on a good prognosis.…”

CCND1 Overexpression in Idiopathic Dilated Cardiomyopathy: A Promising Biomarker?

“…In this regard, some evidence associates the decline in IGF-1 expression with heart disease. For instance, in a cohort study of 337 patients, IGF-1 was reported as a predictor of cardiovascular mortality in patients with heart failure, so older patients with lower serum IGF-1 levels showed higher mortality [ 81 ]. Another report described that IGF-1 signaling was inhibited in end-stage DCM [ 82 ].…”

Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry

“…11 Mediterranea Cardiocentro, Naples, Italy. 12 Operative Unit of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy. 13 Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy.…”