Insulin-like growth factor-binding protein-2 and -3 in gingival crevicular fluid

Takenouchi, Yasuhiro; Ohshima, Mitsuhiro; Yamaguchi, Yoko; Nishida, Takao; Senda, N.; Idesawa, Masataka; Otsuka, Kichibee; Ito, Koichi

doi:10.1111/j.1600-0765.2010.01309.x

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…However, in this study, the correlation between the clinical parameters assessed using OHIs, BOP, PPD, CAL, and CPI with biochemical parameters did not demonstrate any significant association. These findings were contradictory to the findings reported by Takenouchi et al, where they found a positive correlation between the concentration of IGFBP-2 and the probing depth and gingival index but not for IGFBP-3 [ 30 ]. It has been shown that IGFBP-3 regulates epidermal homeostasis by localizing to the nucleus of numerous cultivated cell lines, including epidermal keratinocytes, perhaps by influencing the early stages of keratinocyte terminal differentiation.…”

Section: Discussioncontrasting

confidence: 99%

Association between Chronological Age and IGF-1, IGFBP-3, and CTX Levels in Saliva of Children through Younger Adult Population with Varying Periodontal Status

et al. 2022

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The quest for the most precise and non-invasive technology to monitor the pubertal growth spurt is driven by the role of growth determination in orthodontics. The objective of this study was to estimate the levels of salivary insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3), and cross-linked C-terminal telopeptide of type I collagen (CTX1), and to analyze whether the levels of these biomarkers vary among different chronological age groups with and without periodontal disease. Eighty participants were divided into three groups based on their chronological age: group 1: 6–12 years; group 2: 13–19 years; and group 3: 20–30 years. The assessed clinical parameters included the simplified oral hygiene index (OHI-S), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and community periodontal index (CPI). Using ELISA kits, the IGF-1, IGFBP-3, and CTX1 levels in the saliva samples were estimated. The salivary concentration of IGFBP-3 was significantly associated with age and gender (p < 0.01). However, no significance was observed between subjects with and without periodontal disease. Significant associations existed between the values of IGF-1, IGFBP-3, and CTX1 in saliva among subjects from the various chronological age groups. Estimation of salivary IGF-1 and IGFBP-3 could serve as a useful tool in the assessment of growth maturity and bone remodeling patterns during orthodontic treatment planning.

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Section: Discussioncontrasting

confidence: 99%

Association between Chronological Age and IGF-1, IGFBP-3, and CTX Levels in Saliva of Children through Younger Adult Population with Varying Periodontal Status

et al. 2022

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“…IGFBP-3 has several roles both in systemic and in local regulation (Yamada & Lee 2009), and is a local stimulator of IGF action in bone (Govoni et al 2005). Takenouchi et al found a weak, but non-significant, inverse association between IG-FBP-3 in the gingival crevicular fluid (GCF) and probing depth (Takenouchi et al 2010). Their results are in line with our findings, despite the divergence regarding the selected clinical parameters of periodontal disease.…”

Section: Igfbp-3supporting

confidence: 92%

“…However, the protective effect of serum IGFBP-3 levels on mean CAL was restricted to levels between 300 and 1200 ng/ml (Fig. Takenouchi et al found a weak, but non-significant, inverse association between IG-FBP-3 in the gingival crevicular fluid (GCF) and probing depth (Takenouchi et al 2010). Results support the assumption that serum IGFBP-3 levels might be associated with local homeostasis in periodontal tissue.…”

Section: Igfbp-3mentioning

confidence: 83%

Association between the insulin‐like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study

Harb

Holtfreter

Friedrich³

et al. 2012

J Clinic Periodontology

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“…The upregulation of IGFBP-3 in human gingival fibroblasts increased IGF transport and enhanced periodontal wound healing and regeneration [58]. There was no 17 Disease Markers correlation between IGFBP-3 levels in gingival crevicular fluid with periodontal parameters (e.g., probing depth and gingival index) [59].…”

Section: Discussionmentioning

confidence: 99%

Unveiling the m6A Methylation Regulator Links between Prostate Cancer and Periodontitis by Transcriptomic Analysis

et al. 2022

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Objective. To identify the N6-methyladenosine (m6A) methylation regulator genes linking prostate adenocarcinoma (PRAD) and periodontitis (PD). Materials and Methods. PD and TCGA-PRAD GEO datasets were downloaded and analyzed through differential expression analysis to determine the differentially expressed genes (DEGs) deregulated in both conditions. Twenty-three m6A RNA methylation-related genes were downloaded in total. The m6A-related genes that overlapped between PRAD and PD were identified as crosstalk genes. Survival analysis was performed on these genes to determine their prognostic values in the overall survival outcomes of prostate cancer. The KEGG pathways were the most significantly enriched by m6A-related crosstalk genes. We also performed lasso regression analysis and univariate survival analysis to identify the most important m6A-related crosstalk genes, and a protein-protein interaction (PPI) network was built from these genes. Results. Twenty-three m6A methylation-related regulator genes were differentially expressed and deregulated in PRAD and PD. Among these, seven (i.e., ALKBH5, FMR1, IGFBP3, RBM15B, YTHDF1, YTHDF2, and ZC3H13) were identified as m6A-related cross-talk genes. Survival analysis showed that only the FMR1 gene was a prognostic indicator for PRAD. All other genes had no significant influence on the overall survival of patients with PRAD. Lasso regression analysis and univariate survival analysis identified four m6A-related cross-talk genes (i.e., ALKBH5, IGFBP3, RBM15B, and FMR1) that influenced risk levels. A PPI network was constructed from these genes, and 183 genes from this network were significantly enriched in pathogenic Escherichia coli infection, p53 signaling pathway, nucleocytoplasmic transport, and ubiquitin-mediated proteolysis. Conclusion. Seven m6A methylation-related genes (ALKBH5, FMR1, IGFBP3, RBM15B, YTHDF1, YTHDF2, and ZC3H13) were identified as cross-talk genes between prostate cancer and PD.

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Insulin-like growth factor-binding protein-2 and -3 in gingival crevicular fluid

Abstract: These results indicate that IGFBP-2 is a potential novel marker for periodontal disease progression. As IGFBP-2 modulates bone metabolism and cell migration, IGFBP-2 in the gingival crevicular fluid may reflect periodontal disease activity.

Cited by 6 publications

References 39 publications

Association between Chronological Age and IGF-1, IGFBP-3, and CTX Levels in Saliva of Children through Younger Adult Population with Varying Periodontal Status

Association between Chronological Age and IGF-1, IGFBP-3, and CTX Levels in Saliva of Children through Younger Adult Population with Varying Periodontal Status

Association between the insulin‐like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study

Unveiling the m6A Methylation Regulator Links between Prostate Cancer and Periodontitis by Transcriptomic Analysis

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