Insulin-Like Growth Factor-I and Insulin as Growth and Differentiation Factors in Chicken Embryogenesis

Pablo, Flora de; Robcis, Henri L.; Caldés, Trinidad; Alemany, Jorge; Scavo, Louis M.; Serrano, José

doi:10.3382/ps.0701790

Cited by 20 publications

(7 citation statements)

References 18 publications

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“…While liver IGF-I mRNA was very low until the end of embryogenesis, other chicken embryo tissues had significant IGF-I mRNA levels between days 12-18 (9,34). How production of IGF-I in individual organs (pancreas, brain, etc.)…”

Section: Discussionmentioning

confidence: 93%

Insulin-Like Growth Factor-I Serum Levels Show a Midembryogenesis Peak in Chicken That Is Absent in Growth-Retarded Embryos Culturedex Ovo*

1991

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Insulin-like growth factor-I (IGF-I) is the primary mediator of GH action after birth, but its role as a regulator of prenatal growth is unclear. In a previous study we showed that IGF-I mRNA was expressed in chicken embryos beginning at the blastoderm stage (day 0, newly laid egg). Here we present the ontogeny of serum IGF-I in normal and growth-retarded chicken embryos. Serum samples were pooled from multiple embryos starting on day 4 of development in ovo until hatching (day 21). Extracts of day 2 and 3 whole embryos were also studied. IGF-binding proteins were removed by filtration on Sep-Pak C-18 cartridges. IGF-I was quantitated by a heterologous RIA validated for chicken species. Embryonic IGF-I showed a HPLC profile similar to that of adult chicken serum IGF-I. Serum IGF-I was measurable on day 6 of development (approximately 0.04 ng/ml), reached a peak on day 15 (18 ng/ml), and decreased to a low concentration (0.2 ng/ml) the day before hatching. Embryos cultured ex ovo showed progressive growth retardation after day 10 of development, and by day 20 their weight was 50% of normal. The serum IGF-I concentration of ex ovo cultured embryos was normal on day 10, but remained low until day 21, without the midembryogenesis rise observed in normal embryos. These results support the concept that IGF-I may have a role in general embryonic growth in addition to any paracrine/autocrine action in individual tissues.

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Section: Discussionmentioning

confidence: 93%

Insulin-Like Growth Factor-I Serum Levels Show a Midembryogenesis Peak in Chicken That Is Absent in Growth-Retarded Embryos Culturedex Ovo*

1991

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“…Skalkidou et al (2003) also reported that IGF-1 plays a dominant role in pre- and perinatal growth in human. However, most studies supported that IGF-1 played a larger role in neonatal and postnatal growth (Heyner et al, 1990; De Pablo et al, 1991; Baker et al, 1993; Liu et al, 1998). In this study, a progressive increase pattern of IGF-1 level along with porcine growth and development also indicated an important role of IGF-1 for individual growth.…”

Section: Discussionmentioning

confidence: 99%

Expression Profiles of the Insulin-like Growth Factor System Components in Liver Tissue during Embryonic and Postnatal Growth of Erhualian and Yorkshire Reciprocal Cross F1 Pigs

Pan

Zhang

et al. 2012

Asian Australas. J. Anim. Sci

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ABSTRACT:In Erhualian and Yorkshire reciprocal cross F 1 pig populations, we examined the mRNA expression characteristic of liver-derived IGF-1, IGF-1R, IGF-2, IGF-2R and IGFBP-3 during the embryonic and postnatal developmental periods (E50, E70, E90, D1, D20, D70, D120 and D180). Our results demonstrated that the IGF-system genes mRNA levels exhibited an ontogenetic expression pattern, which was potentially associated with the porcine embryonic development, postnatal growth, organogenesis and even the initiation and acceleration of puberty. The expression pattern of IGF-system genes showed variation in the reciprocal cross (F 1 YE and EY pigs). This study also involved the expression features of imprinted genes IGF-2 and IGF-2R. The parent-of-origin effect of imprinted genes was reflected by their differential expression between the reciprocal crosses populations. The correlation analysis also indicated that the regulatory network and mechanisms involved in the IGF system were a complex issue that needs to be more fully explored. A better understanding of IGF system components and their interactive mechanisms will enable researchers to gain insights not only into animal organogenesis but also into somatic growth development and even reproduction.

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“…These increased pancreatic insulin levels may contribute to elevated plasma insulin levels with chicken embryonic age, with a high peak on ED 17 followed by plateau during pipping and hatching (Lu et al, 2007). Insulin receptors are also found in the blastoderm and in all chicken tissues during embryogenesis (De Pablo et al, 1991). After binding with insulin during the chicken embryogenesis, both have important roles in developmental events, such as growth (Bassas et al, 1987;De Pablo et al, 1991;Lu et al, 2007;Patwardhan et al, 2004), regulation of protein (Hohlweg et al, 1999) and carbohydrate metabolism (Foltzer et al, 1982;Lu et al, 2007;Parkes and Grieninger, 1985).…”

Section: Embryonic and Neonatal Developmental Changes Of Plasma Insulmentioning

confidence: 96%

“…Insulin receptors are also found in the blastoderm and in all chicken tissues during embryogenesis (De Pablo et al, 1991). After binding with insulin during the chicken embryogenesis, both have important roles in developmental events, such as growth (Bassas et al, 1987;De Pablo et al, 1991;Lu et al, 2007;Patwardhan et al, 2004), regulation of protein (Hohlweg et al, 1999) and carbohydrate metabolism (Foltzer et al, 1982;Lu et al, 2007;Parkes and Grieninger, 1985). After hatch, feed-deprived broiler chickens have plasma insulin concentrations that are approximately 0.1 ng mL -1 and after day (D) 14 posthatch, these levels increased to approximately 0.5 ng mL -1 at D 28.…”

Section: Embryonic and Neonatal Developmental Changes Of Plasma Insulmentioning

confidence: 97%

Relationship between Glucose and Pancreatic Hormones during the Embryonic and Postnatal Phase in Chickens

Franssens

Buyse

Decuypere

et al. 2014

Avian Biology Research

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Insulin plays a vital role in the regulation of glucose levels in the bloodstream. Chickens have similar circulating insulin concentrations compared to mammals but still maintain high plasma glucose levels. This phenomenon may be a consequence of the development of insulin resistance early in posthatch life, which may be the result of pertubations in the insulin signalling cascade. In addition, our study demonstrates that the response of plasma glucose and the hepatic glucose transporter 2 mRNA to insulin in broiler chicks during the perinatal period is age-dependent. This review addresses the relationship between glucose and pancreatic hormones in embryonic and posthatch stages in the life cycle of the domestic chicken.

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Insulin-Like Growth Factor-I and Insulin as Growth and Differentiation Factors in Chicken Embryogenesis

Cited by 20 publications

References 18 publications

Insulin-Like Growth Factor-I Serum Levels Show a Midembryogenesis Peak in Chicken That Is Absent in Growth-Retarded Embryos Culturedex Ovo*

Insulin-Like Growth Factor-I Serum Levels Show a Midembryogenesis Peak in Chicken That Is Absent in Growth-Retarded Embryos Culturedex Ovo*

Expression Profiles of the Insulin-like Growth Factor System Components in Liver Tissue during Embryonic and Postnatal Growth of Erhualian and Yorkshire Reciprocal Cross F1 Pigs

Relationship between Glucose and Pancreatic Hormones during the Embryonic and Postnatal Phase in Chickens

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