Insulin-like Growth Factor-I as a Survival Factor for the Bovine Preimplantation Embryo Exposed to Heat Shock1

Jousan, Frank Dean; Hansen, Peter J.

doi:10.1095/biolreprod.104.032102

Cited by 90 publications

(56 citation statements)

References 33 publications

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“…This incidence of apoptotic DNA degeneration was reduced by addition of insulin, insulin like growth factor I (IGF I) and other growth factors to the maturation medium (Wasielak and Bogacki, 2007). Addition of insulin to IVM and subsequent embryo development media reduced not only the incidence of spontaneous apoptosis in bovine embryos (Augustin et al, 2003) but also blocked apoptosis induced by exogenous factors, such as heat shock (Jousan and Hansen, 2004). The obtained data from this study probably shows an interaction between insulin and FSH/or E 2 on the bovine COCs.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Insulin on <i>in vitro</i> Development of Immature Bovine Oocytes

Dashtizad¹,

Wahid²,

Yusoff³

et al. 2010

American Journal of Animal and Veterinary Sciences

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Problem statement: Development of efficient culture system to support embryonic development would be valuable when quality of produced embryos was important. However, the rate of bovine embryo production in vitro was still lower than expected. Present study, including of three experiments, was carried out to investigate the effect of insulin on nuclear maturation and subsequent development of immature bovine oocytes and in vitro fertilized embryos. Approach: Grade one cumulus-oocyte-complexes harvested from slaughterhouse ovaries were selected and randomly allocated in each treatment groups. In experiment 1, in vitro maturation medium (Hepes-buffered medium 199 + fetal calf serum + gonadotrophins + antibiotics) supplemented with 0 (control), 1, 10, 20 and 100 µg mL −1 of insulin. In experiment 2, to eliminate the effect of serum and hormones, Hepesbuffered medium 199 was supplemented with 1 mg mL −1 polyvinyl alcohols (PVA) and same levels of insulin. In experiment 3, the effect of insulin on bovine in vitro embryo development was assessed. Presumptive zygotes were randomly cultured in synthetic oviductal fluid added with 0 (control), 1, 10, 20 and 100 µg mL −1 of insulin. Results: In experiment 1, nuclear maturation and embryo development rates were significantly higher in 1 and 10 µg mL −1 compared with other groups (P<0.05). In experiment 2, both maturation and cleavage rate significantly increased in 1 and 10 µg mL −1 insulin.The only treatment resulted in higher hatchability was 10 µg mL −1 insulin (17.1±2.34%) compared with control (11.34±3.94). In experiment 3, cleavage and morula rates were significantly greater in 1 and 10 µg mL −1 insulin compared with other groups; although the highest rates resulted by using 10 µg mL −1 . Conclusion: Obtained results show that inclusion of 10 µg mL −1 insulin in maturation and culture medium exerted beneficial effects on nuclear maturation of bovine oocytes and in vitro embryo development till morula stage.

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Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Insulin on <i>in vitro</i> Development of Immature Bovine Oocytes

Dashtizad¹,

Wahid²,

Yusoff³

et al. 2010

American Journal of Animal and Veterinary Sciences

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“…The negative effect of heat stress on developmental competence of the oocyte is mainly due to direct effects of elevated temperature [8]. It has been established that apoptosis is a key event during heat stress of oocytes and embryos under in vitro conditions [7,9]. Inhibition of apoptosis by means of using well known anti-apoptotic factors such as IGF-1 [9][10][11][12] may be a useful tool for decreasing the deterioration effects of heat stress on oocyte developmental competence.…”

Section: Introductionmentioning

confidence: 99%

“…It has been established that apoptosis is a key event during heat stress of oocytes and embryos under in vitro conditions [7,9]. Inhibition of apoptosis by means of using well known anti-apoptotic factors such as IGF-1 [9][10][11][12] may be a useful tool for decreasing the deterioration effects of heat stress on oocyte developmental competence. Insulin like grow factor-1 is a potent stimulator of oocyte maturation and subsequent embryonic development [13,14] and is a suppressor of apoptosis [13,15].…”

Section: Introductionmentioning

confidence: 99%

Unexpected detrimental effect of Insulin like growth factor-1 on bovine oocyte developmental competence under heat stress

Zhandi

Towhidi

Nasr-Esfahani

et al. 2009

J Assist Reprod Genet

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Purpose To investigate the effects of Insulin like growth factor-1 (IGF-1) on bovine oocyte developmental competence under heat stress. Methods In Experiment 1, bovine cumulus-oocyte complexes (COCs) were cultured at 38.5 or 41°C for the first 12 h of maturation in the presence of either 100 ng/ml human recombinant (hr)-IGF-1 or acetic acid. In Experiment 2, COCs were cultured in 38.5 or 41°C for the first 12 h of maturation in the presence either of 100 ng/ml hr-IGF-1 or acetic acid. After fertilization, putative zygotes were cultured for 8 days.Results In experiment 1, addition of rh-IGF-1 to maturation medium at 38.5°C significantly increased the proportion of M II oocytes and decreased the percentage of TUNEL-positive oocytes compared to the other groups. However, addition of rh-IGF-1 to maturation medium under heat stress increased the percentage of TUNEL-positive oocytes. In experiment 2, addition of rh-IGF-1 under heat sress did not affect cleavage rate, whereas, blastocyst formation rate decreased in heatstressed and heat-stressed plus rh-IGF-1 groups. Similarly, The number of trophectoderm cells and total cell number were decreased in heat-stressed and heat-stressed plus rh-IGF-1 groups and the percentage of TUNEL-positive nuclei were increased in heat-stressed and heat-stressed plus rh-IGF-1 groups compared to the other groups. Conclusion The results of the present study demonstrate that IGF-1 decreases oocyte developmental competence and total cell number and increases TUNEL-positive nuclei at heat stress condition. These unexpected results of IGF-1 during maturation period under heat stress condition warrant further optimizations and investigations.

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“…Analizando las referencias mencionadas, así como otras fuentes bibliográficas sobre el tema 3,6,7,8,9,12,13,16,23,25,27,28 , se concluye que en vacas lecheras se produce un efecto favorable ante la administración de bST recombinante en el porcentaje de concepción, ya sea integrada a los programas de sincronización de la ovulación en vacas de primer servicio o administrada a las vacas subfértiles al momento de la inseminación. El mecanismo por el cual la bST favorece el porcentaje de concepción no está totalmente dilucidado, pero opera mediante su efecto en la maduración del ovocito, fertilización y desarrollo embrionario.…”

Section: Conclusionesunclassified

Impacto del balance energético negativo en vacas lecheras tratadas con somatotropina recombinante bovina

Ninabanda

2018

Rev. vet.

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Impacto del balance energético negativo en vacas lecheras tratadas con somatotropina recombinante bovinaNinabanda, J.J.Escuela Superior Politécnica de Chimborazo (ESPOCH). Facultad de Ciencias Pecuarias, Panamericana Sur km 1 ½, Riobamba, Ecuador. E-mail: nina_ jaky@hotmail.com Resumen Ninabanda, J.J.: Impacto del balance energético negativo en vacas lecheras tratadas con somatotropina recombinante bovina. Rev. vet. 29: 1, 68-72, 2018. El objetivo de la presente revisión bibliográfica fue analizar el efecto de la somatotropina recombinante bovina sobre el desempeño productivo y reproductivo de vacas lecheras en período de post-parto, así como el impacto del balance energético negativo sobre los indicadores energético-proteicos y la capacidad gluconeogénica. Para ello fue necesario reunir datos sobre la alteración de la fertilidad y el retraso de la reactivación ovárica, dado que la primera ovulación ocurre alrededor de las dos semanas posteriores. Para la recopilación de información se implementó una investigación metodológica que incluyó: criterios de búsqueda (balance energético negativo y celo post-parto), criterios de inclusión (anestro, desarrollo folicular y hormona somatotropina recombinante bovina) y finalmente criterios de exclusión (peso y condición corporal). Muchos de los autores sugieren valorar las implicaciones de la hormona en animales que se encuentren en las primeras semanas de lactancia, así como su efecto sobre el metabolismo corporal y la composición de la leche, que impactan en el valor nutritivo y las condiciones para la industrialización del producto.Palabras clave: vacas lecheras, balance energético-proteico, período de transición, somatotropina.Abstract Ninabanda, J.J.: Impact of negative energy balance in dairy cows treated with recombinant bovine somatotropin. Rev. vet. 29: 1, 68-72, 2018. The objective of the present review was to analyze the productive and reproductive performance of the bovine recombinant somatotropin effect in dairy cows in post-partum period, as well as the impact that occurs with the negative energy balance, on the energetic-protein indicators and gluconeogenic capacity. For which it was necessary to compile the results of the schemes in terms of: alteration of fertility and delaying the ovarian reactivation which results in a first ovulation around the 2 weeks after this point. For the summary of information a methodological investigation was implemented that included: search approaches (negative energy balance and post-partum heat), inclusion approaches (anestrus, follicular development, and bovine recombinant somatotropin) and finally exclusion approaches (live weigh and corporal condition). Many of the authors suggest to value the implications of the hormone in animals that are in the first weeks of nursing, as well as their effect on the corporal metabolism and the milk composition, that impact under the nutritious value and the conditions for the industrialization of the product.

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Insulin-like Growth Factor-I as a Survival Factor for the Bovine Preimplantation Embryo Exposed to Heat Shock1

Cited by 90 publications

References 33 publications

Synergistic Effect of Insulin on <i>in vitro</i> Development of Immature Bovine Oocytes

Synergistic Effect of Insulin on <i>in vitro</i> Development of Immature Bovine Oocytes

Unexpected detrimental effect of Insulin like growth factor-1 on bovine oocyte developmental competence under heat stress

Impacto del balance energético negativo en vacas lecheras tratadas con somatotropina recombinante bovina

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