Insulin-Like Growth Factor-I (IGF-I) Stimulates Interleukin-7 (IL-7) Synthesis and Secretion in Primary Cultures of Human Thymic Epithelial Cells

Goffinet, Lindsay; Martens, Henri; Geenen, Vincent

doi:10.1210/endo-meetings.2011.part1.p6.p1-149

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“…Given that TREC formation is due to recombinase‐activating gene (RAG) activity and that RAG is strongly induced by IL‐7, the relationship between IGF‐1 and IL‐7 production by thymic epithelial cells (TECs) was explored in vitro . IGF‐1 induces strong expression and release of IL‐7, which can be completely counteracted by blocking antibody to IGF‐1R (Fig.…”

Section: Somatotrope Axis and Thymic Functionmentioning

confidence: 99%

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Somatotrope GHRH/GH/IGF‐1 axis at the crossroads between immunosenescence and frailty

Bodart

Goffinet

Morrhaye

et al. 2015

Annals of the New York Academy of Sciences

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Immunosenescence, characterized by complex modifications of immunity with age, could be related to frailty syndrome in elderly individuals, leading to an inadequate response to minimal aggression. Functional decline (i.e., the loss of ability to perform activities of daily living) is related to frailty and decreased physiological reserves and is a frequent outcome of hospitalization in older patients. Links between immunosenescence and frailty have been explored and 20 immunological parameters, including insulin-like growth factor-1 (IGF-1), thymopoeisis, and telomere length, were shown to be affected in elderly patients with functional decline. A strong relationship between IGF-1 and thymic ouput was evidenced. IGF-1, a mediator of growth hormone (GH), was subsequently shown to induce interleukin-7 secretion in cultured primary human thymic epithelial cells. We are exploring the stress hypothesis in which an acute stressor is used as the discriminator of frailty susceptibility. GH can counteract the deleterious immunosuppressive effects of stress-induced steroids. Under nonstress conditions, the immunosenescent system preserves physiological responses, while under stress conditions, the combination of immunosenescence and a defect in the somatotrope axis might lead to functional decline.

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Section: Somatotrope Axis and Thymic Functionmentioning

confidence: 99%

“…** P < 0.01; *** P < 0.001 (by Wilcoxon's signed rank test, N = 6). Adapted, with permission, from Goffinet et al …”

Section: Somatotrope Axis and Thymic Functionmentioning

confidence: 99%

Somatotrope GHRH/GH/IGF‐1 axis at the crossroads between immunosenescence and frailty

Bodart

Goffinet

Morrhaye

et al. 2015

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

Insulin-Like Growth Factor-I (IGF-I) Stimulates Interleukin-7 (IL-7) Synthesis and Secretion in Primary Cultures of Human Thymic Epithelial Cells

Cited by 1 publication

References 0 publications

Somatotrope GHRH/GH/IGF‐1 axis at the crossroads between immunosenescence and frailty

Somatotrope GHRH/GH/IGF‐1 axis at the crossroads between immunosenescence and frailty

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