Insulin-like growth factor I promotes leiomyoma cell growth in vitro

Strawn, Estil; Novy, Miles J.; Burry, Kenneth A.; Bethea, Cynthia L.

doi:10.1016/0002-9378(95)91420-x

Cited by 68 publications

(42 citation statements)

References 24 publications

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“…These factors are structurally related to proinsulin and promote cellular proliferation, differentiation, and cell survival Yu and Berkel 1999). Evidence exists for dissimilar roles of the two IGFs, in that IGF-II appears to be primarily responsible for the terminal differentiation of skeletal muscle cells and the down-regulation of IGF-I receptor gene expression, whereas IGF-I is responsible for myogenesis (Rosenthal et al 1994;Strawn et al 1995). In most situations the IGF binding proteins inhibit the actions of IGFs by blocking their binding to the receptor; in certain circumstances, however, these binding proteins may be able to enhance the action of IGF-I by binding to it and preventing its degradation, thereby increasing its bioavailability in target tissues (Yu and Berkel 1999).…”

Section: Growth Factors Identified In Fibroidsmentioning

confidence: 99%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

496

392

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Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor-β 3, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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Section: Growth Factors Identified In Fibroidsmentioning

confidence: 99%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

496

392

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“…IGF-1 stimulates mitogenesis of the normal epithelium and proliferation of both endometrial cancers and leiomyoma cells (Strawn et al, 1995;Klotz et al, 2000). In the mouse uterine model, the in vivo proliferative response of IGF-1 requires ERa, even in the presence of a functional IGF-1 signaling response, as IGF-1 signaling to MAPK or Akt is unaffected by the loss of ER (Klotz et al, 2002).…”

Section: Igf1-r Crosstalk With Er and Prmentioning

confidence: 99%

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation

2004

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“…Although the exact etiology of UL is unknown, there are several factors influencing the growth of UL [5]. They www.…”

Section: Introductionmentioning

confidence: 99%

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Keshavarzi

Salimi

Mohammadpour‐Gharehbagh

et al. 2017

Ginekol Pol

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Objectives: Vascular endothelial growth factor (VEGF) is an important angiogenic factor that regulates angiogenesis and mediates sex steroid-induced cell growth. The present study investigated the association of VEGF gene-2578C/A (rs699947) and −2549 insertion/deletion polymorphisms in the promoter region of VEGF-A gene and uterine leiomyoma susceptibility in Southeast of Iran. Material and methods:One hundred and fifty five women with uterine leiomyoma and 157 age, BMI, and ethnicity matched healthy women were enrolled in this study. VEGF gene -2578C/A polymorphism genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, and the -2549 insertion/deletion polymorphism was analyzed by PCR method. Results:The frequency of alleles and genotypes of VEGF-2578C/A polymorphism was not different between women with uterine leiomyoma and the controls; however, a significant association was revealed between II genotype of -2549 insertion/deletion (I/D) polymorphism of VEGF gene and uterine leiomyoma. Conclusions:The findings showed that VEGF gene -2549 insertion/deletion polymorphism was associated with uterine leiomyoma.

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Insulin-like growth factor I promotes leiomyoma cell growth in vitro

Cited by 68 publications

References 24 publications

Etiology and pathogenesis of uterine leiomyomas: a review.

Etiology and pathogenesis of uterine leiomyomas: a review.

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation

The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

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