The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Keshavarzi, Farshid; Salimi, Saeedeh; Mohammadpour‐Gharehbagh, Abbas; Teimoori, Batool; Yazdi, Atefeh; Farajian-Mashhadi, Farzaneh; Yaghmaei, Minoo; Mokhtari, Mojgan

doi:10.5603/gp.a2017.0022

Cited by 6 publications

(5 citation statements)

References 27 publications

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“… 44 The role of the VEGF −2549 polymorphism in uterine leiomyoma was investigated in the Iranian population in a previous investigation, whose results, similar to ours, demonstrated that the frequency of the I/I genotype was higher than that of the D/D genotype in the patient group than in the control group. 44 That study also proposed a higher risk of uterine leiomyoma in women carrying the I/I genotype compared with the D/D genotype. 44 The VEGF gene is involved in angiogenesis and tumor genesis in cancer.…”

Section: Discussionsupporting

confidence: 75%

“… 44 That study also proposed a higher risk of uterine leiomyoma in women carrying the I/I genotype compared with the D/D genotype. 44 The VEGF gene is involved in angiogenesis and tumor genesis in cancer. 45 The frequency of the D/D genotype was higher in patients with breast cancer than in the control group, and the level of VEGF was higher in patients than in the control group in a prior study.…”

Section: Discussionmentioning

confidence: 94%

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Vascular Endothelial Growth Factor Genetic Variant is Associated with In-Stent Restenosis after Percutaneous Coronary Intervention

Asgarbeik¹,

Vahidi²,

Hasanzad³

et al. 2022

JTHC

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Background: In-stent restenosis (ISR) is an inevitable complication of percutaneous coronary intervention, with genetic factors thought to play a role in its pathogenesis. The VEGF gene can have an inhibitory effect on ISR development. Accordingly, in the present study, we investigated the role of −2549 VEGF (insertion/deletion [I/D]) variants in ISR formation. Methods: Patients with ISR (ISR+) (n=53) and patients without ISR (ISR-) (n=67) were enrolled in this case-control study based on follow-up angiography 1 year after percutaneous coronary intervention between 2019 and 2020. The clinical characteristics of the patients were evaluated, and the frequencies of the alleles and genotypes of −2549 VEGF (I/D) variants were determined using polymerase chain reaction. The χ2 test was performed for the calculation of genotypes and alleles. A P value of less than 0.05 was considered the level of significance. Results: This study recruited 120 individuals at a mean age of 61.43±8.91 years in the ISR+ group and 62.09±7.94 years in the ISR- group. Women and men, respectively, comprised 26.4% and 73.6% of the ISR+ group and 43.3% and 56.7% of the ISR- group. A significant association was observed between the VEGF −2549 genotype frequency and ISR. The frequency of the insertion/insertion (I/I) allele was significantly higher in the ISR+ group than in the ISR- group, while the frequency of the D/D allele was higher in the latter group. Conclusion: Regarding ISR development, the I/I allele may be a risk allele and the D/D allele a protective allele.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 94%

Vascular Endothelial Growth Factor Genetic Variant is Associated with In-Stent Restenosis after Percutaneous Coronary Intervention

Asgarbeik¹,

Vahidi²,

Hasanzad³

et al. 2022

JTHC

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“…However, it is important to highlight that there are controversies regarding the potential of the D allele as a risk factor for clinical conditions, since a published study positively associated genotype II and/or allele I with pathologies such as uterine leiomyoma. 10 The increase in the frequency of smoking in the control group is not in accordance with a previous study 23 , in which women with PCOS showed higher frequency in relation to smoking, as well as a greater risk of worsening the metabolic profile. The increased frequency of family recurrence of PCOS in the study group is supported by the literature that evidences genetic factors in the etiology of this pathology, leading to a shared genetic predisposition.…”

Section: Discussioncontrasting

confidence: 58%

VEGF gene rs35569394 polymorphism in patients with Polycystic Ovary Syndrome

Fernandes

Marqui

Teles

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The relationship between the clinicopathological and sociodemographics characteristics of acral melanomas diagnosed at BACKGROUND: This study aimed to investigate the frequency of VEGF gene insertion (I) / deletion (D) polymorphism (rs35569394) in patients with Polycystic Ovarian Syndrome (PCOS) and to compare with a control population to verify its association with the pathology. METHODS: 206 women participated in this study, 103 with PCOS (group of patients) and 103 without the disease (control group). After extraction of genomic DNA from the samples, molecular analysis was performed by Polymerase Chain Reaction (PCR) and electrophoresis in polycrylamide. Descriptive analysis, univariate analysis and logistic regression model were used. Results were presented in odds ratio (OR) and 95% confidence interval (95% CI), considering the significance of p <0.05. RESULTS: There were no statistical differences between patients and controls for allele frequencies (χ2 = 1.16, p = 0.56). The genotypic frequency distribution was in Hardy Weinberg equilibrium for the patients (χ2 = 2.42; p <0.05), but not for the control group (χ2 = 7.26; p <0.05). Regarding risk factors for the syndrome, a history of familial PCOS is more frequent among women with the syndrome. CONCLUSIONS: In the present study, there is no association between VEGF gene I / D polymorphism and PCOS.

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“…There may be more than two genotypes in the same gene locus, which is prevalent in areas with noncoding protein or without important adjustment functions in gene sequences. 18 The human VEGF gene is located on long arm of chromosome 6p21.3. The gene encoding VEGF is about 14 Kb in length and is composed of 8 exons and 7 introns alternately.…”

Section: Discussionmentioning

confidence: 99%

Association between Vascular Endothelial Growth Factor and Clinical Outcomes of IVF-ET/ICSI

Chen¹,

Zheng²,

Wang³

et al. 2019

J Coll Physicians Surg Pak

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The −2549 insertion/deletion polymorphism of VEGF gene associated with uterine leiomyoma susceptibility in women from Southeastern Iran

Cited by 6 publications

References 27 publications

Vascular Endothelial Growth Factor Genetic Variant is Associated with In-Stent Restenosis after Percutaneous Coronary Intervention

Vascular Endothelial Growth Factor Genetic Variant is Associated with In-Stent Restenosis after Percutaneous Coronary Intervention

VEGF gene rs35569394 polymorphism in patients with Polycystic Ovary Syndrome

Association between Vascular Endothelial Growth Factor and Clinical Outcomes of IVF-ET/ICSI

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