Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study

Adachi, Yasushi; Nojima, Masanori; Mori, Mitsuru; Matsunaga, Yasutaka; Akutsu, Noriyuki; Sasaki, Shigeru; Endo, Takao; Kurozawa, Youichi; Wakai, Kenji; Tamakoshi, Akiko; Study, for Jacc

doi:10.1007/s13277-016-5360-z

Cited by 25 publications

(32 citation statements)

References 32 publications

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“…Hence, the molar difference of (IGFBP3-IGF1) could represent the level of the free type of IGFBP3[30]. The molar difference of IGFBP3-IGF1 was inversely and significantly correlated with the future risk of esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this parameter may be a candidate predictive marker of esophageal cancer. Moreover, we have reported that free IGFBP3 showed a reversed risk for hepatic cancer[30]. Thus, the molar difference of IGFBP3-IGF1 may be an important parameter.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we assessed the molar difference between IGFBP3 and IGF1, which is considered to represent free IGFBP3[30]. …”

Section: Methodsmentioning

confidence: 99%

“…Additionally, low serum levels of total-IGFBP3 or free-IGFBP3, which can be approximated by the molar difference (IGFBP3-IGF1), upregulate the future risk of neoplasms[29,30]. However, the association between the risk of esophageal carcinoma and serum levels of IGF related compounds has not been reported.…”

Section: Introductionmentioning

confidence: 99%

“…However, the association between the risk of esophageal carcinoma and serum levels of IGF related compounds has not been reported. Although several correlations between the risk of cancer death and IGF axial proteins from the Japan Collaborative Cohort (JACC) Study were published[30-32], the incidence of esophageal carcinoma has not been reported. Therefore, we assessed relationships between these parameters and esophageal tumor risk in a nested, case-control study in a prospective cohort study of participants in the JACC study.…”

Section: Introductionmentioning

confidence: 99%

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Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Adachi

Nojima

Mori

et al. 2017

WJG

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AIMTo assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma.METHODSWe assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.RESULTSThirty-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95%CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150).CONCLUSIONThe free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In addition, we assessed the molar difference between IGFBP3 and IGF1, which is considered to represent free IGFBP3[30]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Adachi

Nojima

Mori

et al. 2017

WJG

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Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Yang

Simon

et al. 2019

Hepatology

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Although adherence to healthy dietary guidelines has been associated with a reduced risk of several health outcomes, including cardiovascular diseases, type 2 diabetes, and some cancers, little is known about the role of dietary patterns in the development of hepatocellular carcinoma (HCC). We prospectively assessed the associations of three key commonly used a priori dietary patterns—the Alternative Healthy Eating Index‐2010 (AHEI‐2010), Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH)—with risk of incident HCC in the Health Professionals Follow‐Up Study (HPFS) and the Nurses’ Health Study (NHS), two large prospective cohort studies. Diet was assessed almost every 4 years using validated food frequency questionnaires (FFQs). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. During up to 32 years of follow‐up, 160 incident HCC cases were identified. After adjustment for most HCC risk factors, participants in the highest tertile of Alternative Healthy Eating Index‐2010 (AHEI‐2010) had a multivariable HR of 0.61 (95% CI, 0.39‐0.95; Ptrend = 0.03), compared with those in the lowest tertile. There was a suggestive, but nonsignificant, inverse association for Alternate Mediterranean Diet (AMED; HR = 0.75; 95% CI, 0.49‐1.15; Ptrend = 0.18) and a null association for Dietary Approaches to Stop Hypertension (DASH; HR = 0.90; 95% CI, 0.59‐1.36; Ptrend = 0.61) in relation to the risk of HCC development. Conclusion: Our findings suggest that better adherence to the AHEI‐2010 may decrease the risk of developing HCC among U.S. adults. Future studies are needed to replicate our results, examine these associations in other populations, and elucidate the underlying mechanisms.

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Risk Associations of Glycemic Burden and Obesity With Liver Cancer—A 10‐Year Analysis of 15,280 Patients With Type 2 Diabetes

Mao

Lau

et al. 2022

Hepatol Commun

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Liver is a major site for glucose metabolism. Patients with type 2 diabetes (T2D) and obesity have increased risk of liver cancer. We explored the association of glycemic burden (GB) and obesity with liver cancer in T2D in the prospective Hong Kong Diabetes Register (1995‐2019). We calculated GB using the area under the curve above hemoglobin A1c (HbA1c) of 5.7% and defined obesity as body mass index (BMI) ≥ 25 kg/m2. We used Cox proportional hazards models to evaluate the association between GB and liver cancer. We included 15,280 patients with at least 10 years of disease duration before liver cancer occurred or censor date, ≥3 years of observation, and ≥5 HbA1c measurements (64% male, age: 58.23 ± 12.47 years, HbA1c: 7.60 ± 1.65%, BMI: 25.58 ± 4.10 kg/m2). We excluded 3 years of HbA1c values before liver cancer to avoid reverse causality. Every 1‐SD increase in GB was associated with an adjusted hazard ratio (aHR) of liver cancer of 1.22 (95% confidence interval [CI]: 1.01‐1.47). The top GB quartile group (range: >2.41) had aHR of 1.78 (1.01‐3.13) versus the lowest quartile group (0‐1.19). The aHRs for each SD increase in GB were 1.34 (1.05, 1.70) in the obese group and 1.12 (0.81‐1.53) in the nonobese group, but no interaction (Pinteraction = 0.120). When stratified by GB median (1.69 [1.13, 2.43]) and obesity, obese patients with high GB had the highest aHR of 2.51 (1.44‐4.37) for liver cancer versus the nonobese group with low GB, but no interaction (Pinteraction = 0.071). Subgroup analysis of patients with available hepatitis B surface antigen status (n = 9,248) yielded similar results. Conclusion: Our results emphasized the importance of glycemic and weight control for reducing the risk of liver cancer in T2D.

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Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study

Cited by 25 publications

References 32 publications

Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Risk Associations of Glycemic Burden and Obesity With Liver Cancer—A 10‐Year Analysis of 15,280 Patients With Type 2 Diabetes

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