Insulin Modulates Myogenesis and Muscle Atrophy Resulting From Skin Scald Burn in Young Male Rats

Quintana, Hananiah Tardivo; Baptista, Vivianne Izabelle de Araújo; Lazzarin, Mariana Cruz; Antunes, Hanna Karen Moreira; Sueur-Maluf, Luciana Le; Oliveira, Camila Aparecida Machado de; Oliveira, Flávia de

doi:10.1016/j.jss.2020.07.040

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Based on previous studies, the preoperative anxiety of burned children is different from that of adults. The incidence rate of preoperative anxiety in children with burns exceeds 60%, while that of adults is much lower than 60% (16)(17)(18). In addition, according to a large number of clinical practices, the preoperative anxiety of children with burns will also have a certain impact on their postoperative pain (19,20).…”

Section: Discussionmentioning

confidence: 99%

Preoperative Anxiety and Postoperative Pain in Children with Burn Patients and Their Correlation Analysis

2023

ircmj

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Background: Burn is a kind of skin tissue damage under the influence of heat source, which is a common type of accidental injury in current society. Objective: To investigate the status of preoperative anxiety and postoperative pain in children with burn patients, and to analyze the correlation between preoperative anxiety and postoperative pain. Methods: A total of 108 pediatric patients who underwent burn surgery under general anesthesia in our hospital from October 2020 to August 2021 were selected. FLACC and Facial Expression Pain Scale were used to evaluate the pain of the children, and STAI and YPAS were used to evaluate the anxiety of the children. Correlation was used to analyze the effect of preoperative anxiety on postoperative pain in burn children. Results: Preoperative anxiety and severe anxiety accounted for more than 50% of burn children, and there was a statistically significant difference in preoperative anxiety and postoperative pain between 1-3-year-old children and 4-12-year-old children. The influencing factors of postoperative pain in children with burns were analyzed, including burn area, depth of burn, and previous operations. The multivariate analysis showed that the risk factors for postoperative pain in children were age, burn area, depth of burn, preoperative anxiety of children, and parental trait anxiety, after statistical test, it shows that each influencing factor has a significant influence on postoperative pain in children (P < 0.05). In the correlation analysis of preoperative anxiety and postoperative pain in children with burns, it was shown that preoperative anxiety in children aged 1 to 3 years had a significant impact on postoperative pain of children, and the correlation analysis showed that preoperative anxiety of children with burns There was a positive correlation between anxiety score and postoperative pain (r=0.479, P=0.001). Conclusion: The incidence of preoperative anxiety in children with burn patients is high, and the postoperative pain scores are also different in different age groups. In addition, there is a current correlation between preoperative anxiety and postoperative pain in children with burn patients, and the correlation is positively correlated, that is, the higher the patient's anxiety score, the more intense the patient's postoperative pain.

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Section: Discussionmentioning

confidence: 99%

Preoperative Anxiety and Postoperative Pain in Children with Burn Patients and Their Correlation Analysis

2023

ircmj

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Skeletal muscle wasting after burn is regulated by a decrease in anabolic signaling in the early flow phase

Dombrecht,

Van Daele,

Van Asbroeck

et al. 2023

Burns

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The Role of Mitochondria in Mediation of Skeletal Muscle Repair

Paez

Pitzer

2023

Muscles

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Musculoskeletal health is directly linked to independence and longevity, but disease and aging impairs muscle mass and health. Complete repair after a pathological or physiological muscle injury is critical for maintaining muscle function, yet muscle repair is compromised after disuse, or in conditions such as metabolic diseases, cancer, and aging. Regeneration of damaged tissue is critically dependent upon achieving the optimal function of satellite cells (muscle stem cells, MSCs). MSC remodeling in muscle repair is highly dependent upon its microenvironment, and metabolic health of MSCs, which is dependent on the functional capacity of their mitochondria. Muscle repair is energy demanding and mitochondria provide the primary source for energy production during regeneration. However, disease and aging induce mitochondrial dysfunction, which limits energy production during muscle regeneration. Nevertheless, the role of mitochondria in muscle repair likely extends beyond the production of ATP and mitochondria could provide potentially important regulatory signaling to MSCs during repair from injury. The scope of current research in muscle regeneration extends from molecules to exosomes, largely with the goal of understanding ways to improve MSC function. This review focuses on the role of mitochondria in skeletal muscle myogenesis/regeneration and repair. A therapeutic strategy for improving muscle mitochondrial number and health will be discussed as a means for enhancing muscle regeneration. Highlights: (a). Mitochondrial dysfunction limits muscle regeneration; (b). Muscle stem cell (MSC) function can be modulated by mitochondria; (c). Enhancing mitochondria in MSCs may provide a strategy for improving muscle regeneration after an injury.

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Insulin Modulates Myogenesis and Muscle Atrophy Resulting From Skin Scald Burn in Young Male Rats

Cited by 3 publications

References 52 publications

Preoperative Anxiety and Postoperative Pain in Children with Burn Patients and Their Correlation Analysis

Preoperative Anxiety and Postoperative Pain in Children with Burn Patients and Their Correlation Analysis

Skeletal muscle wasting after burn is regulated by a decrease in anabolic signaling in the early flow phase

The Role of Mitochondria in Mediation of Skeletal Muscle Repair

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