Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

Abstract

Pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share a common pathophysiology associated with similar risk factors. Genetic variants used to determine the risk of developing T2DM might also be associated with the prevalence of GDM. The aim of the present study was to scrutinize the relationship between the G972R polymorphism of the insulin receptor substrate-1 (IRS-1) gene with GDM in the Saudi female population. This is a case-control study that monitored 500 Saudi women. Subjects with GDM (n = 200) were compared with non-GDM (n = 300) controls. We opted to evaluate rs1801278 polymorphism in the IRS1 gene, which plays a critical role in the insulin-signaling pathway. Genotyping was performed with the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The frequency of the rs1801278 polymorphism was significantly higher in women with GDM than in women with non-GDM (for TT + CT versus CC: P = 0.02). Additionally, there was a significant increase in the frequency of the Arg-encoding mutant allele from GDM to non-GDM (for T versus C: P = 0.01). Our results suggest that the rs1801278 polymorphism in the IRS-1 gene is involved in the occurrence of GDM in the Saudi population.

<p>Genetic variants linked to T2DM risk in Kurdish populations</p>

“…147545). [5][6][7][8] Another gene associated with T2DM is the CCR5 gene (accession number. 601373).…”

Polymorphisms&nbsp;of&nbsp;TGF-β1&nbsp;and&nbsp;TGF-β3&nbsp;in Chinese Women With Gestational Diabetes Mellitus

“…For example, Transcription factor 7-like 2 rs12255372 variant is suggested to interact with adiposity to alter β-cell function in 132 Mexican-American families with GDM [31]. Homozygosity for Insulin receptor substrate-1 G972R polymorphism might indicate an increased risk for GDM in Saudi women [32]. Interestingly, many GDM associated candidate genes can express cytokines that have been implicated in the inflammatory conditions during pregnancy [33].…”

Genetic variation of IRS1 gene in women with gestational diabetes mellitus in third trimester stage in Iraq

“…The results of this study revealed that the variant (rs 1801278) of the IRS-1gene is significantly associated with GDM. The previous studies (Fallucca et al, 2006 ;Alharbi et al, 2014) [23,24,25] indicate that the polymorphic allele T is considerably related with IRS-1 and may be complicated in the development of gestational diabetes. In contrast, Shaat et al,(2005) [26] suggest that did not detect any relationship between the (rs 1801278) polymorphism and gestational diabetes.…”