Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease

Lutski, Miri; Weinstein, Galit; Goldbourt, Uri; Tanné, David

doi:10.3233/jad-161016

Cited by 36 publications

(29 citation statements)

References 35 publications

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“…Evidence has gathered suggesting that BIR seems to be a shared pathological feature of metabolic and cognitive disturbances in T2DM, obesity, cardiovascular disease, and dementia patients (Kullmann et al 2016;Lutski et al 2017), which may provide the missing link between these disorders. Indeed, recent evidence suggests that insulin resistance is related to subsequent poorer cognitive performance and greater cognitive decline among patients with cardiovascular disease with and without diabetes (Lutski et al 2017).…”

Section: Glycemic Controlmentioning

confidence: 99%

“…Indeed, recent evidence suggests that insulin resistance is related to subsequent poorer cognitive performance and greater cognitive decline among patients with cardiovascular disease with and without diabetes (Lutski et al 2017). Clinical investigation of the link between the obesity and BIR showed that obese men respond to cognitive but not to catabolic brain insulin signalling (Hallschmid et al 2008), indicating that not all insulin activities in the brain have been equally affected by BIR and that insulin resistance in metabolic disorders does not uniformly affect all target cells and intracellular signaling pathways in the brain (Könner and Brüning 2012).…”

Section: Glycemic Controlmentioning

confidence: 99%

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The diabetic brain and cognition

et al. 2017

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The prevalence of both Alzheimer's disease (AD) and vascular dementia (VaD) is increasing with the aging of the population. Studies from the last several years have shown that people with diabetes have an increased risk for dementia and cognitive impairment. Therefore, the authors of this consensus review tried to elaborate on the role of diabetes, especially diabetes type 2 (T2DM) in both AD and VaD. Based on the clinical and experimental work of scientists from 18 countries participating in the International Congress on Vascular Disorders and on literature search using PUBMED, it can be concluded that T2DM is a risk factor for both, AD and VaD, based on a pathology of glucose utilization. This pathology is the consequence of a disturbance of insulin-related mechanisms leading to brain insulin resistance. Although the underlying pathological mechanisms for AD and VaD are different in many aspects, the contribution of T2DM and insulin resistant brain state (IRBS) to cerebrovascular disturbances in both disorders

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Section: Glycemic Controlmentioning

confidence: 99%

Section: Glycemic Controlmentioning

confidence: 99%

The diabetic brain and cognition

et al. 2017

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“…Additionally, characteristics related to type 2 diabetes, including higher blood glucose levels, higher serum fasting insulin and insulin resistance [12][13][14], have been linked to cognitive dysfunction, accelerated cognitive decline and dementia in elderly individuals, even in those without diabetes [14,15]. Moreover, in addition to blood glucose and HbA 1c levels, poor long-term HbA 1c trajectories [16] and glucose peaks [17] have been shown to be associated with cognitive function.…”

Section: Type 2 Diabetes Precedes Cognitive Dysfunctionmentioning

confidence: 99%

The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?

Ganmore

Beeri

2018

Diabetologia

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The association between type 2 diabetes and cognitive dysfunction is well established. Prevention of the development of type 2 diabetes and its complications, as well as cognitive dysfunction and dementia, are leading goals in these fields. Deciphering the causality direction of the interplay between type 2 diabetes and cognitive dysfunction, and understanding the timeline of disease progression, are crucial for developing efficient prevention strategies. The prevailing perception is that type 2 diabetes leads to cognitive dysfunction and dementia. There is substantial evidence showing that accelerated cognitive decline in type 2 diabetes starts in midlife (mean age 40-60 years) and that it may even begin at the prediabetes stage. However, in this issue of Diabetologia, Altschul et al (doi: https://doi.org/10.1007/s00125-018-4645-8 ) show evidence for the reverse causality hypothesis, i.e. that lower cognitive function precedes poor glycaemic control. They found that cognitive function at early adolescence (age 11 years) predicts both HbA levels and cognitive function at age 70 years. Moreover, they found that lower cognitive function at age 70 is associated with an increase in HbA from age 70 to 79 years. Based on these findings, future studies should explore whether developing prevention strategies that target young adolescents with lower cognitive function will result in prevention of type 2 diabetes, breaking the vicious cycle of type 2 diabetes and cognitive dysfunction.

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“…Сравнительно меньше изучено поражение головного мозга при СД -диабетическая энцефалопатия (ДЭ). При ДЭ поражение головного мозга рассматривается с точки зрения нарушения чувствительности клеток головного мозга к инсулину -инсулинорезистентности (ИР), что сближает патогенез ДЭ с патогенезом болезни Альцгеймера (БА) [3]. ИР определяется как патологическое состояние, при котором клетки утрачивают способность ответа на метаболическую активность инсулина и инсулинопосредованных процессов в головном мозге, включая пищевое поведение, продукцию глюкозы печенью, мобилизацию жировой массы, терморегуляцию, ответ на гипогликемию и нейрональные функции, что может являться индикатором ИР [4].…”

Section: обзорыunclassified

Cerebral insulin resistance: current concepts of the pathogenesis and possible therapeutic strategies

Esin

Хайруллин

Esin

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The review presents current concepts about the problem of cerebral insulin resistance (IR). It has now been established that cerebral IR plays a key role in the pathogenesis of degenerative and metabolic diseases of the brain. Based on literature data and own clinical experience, the authors recommend to use the standardized extract of ginkgo biloba EGb761 as a cellular protector, which increases insulin sensitivity of cells and reduces atherogenesis, in order to improve cognitive functions and quality of life in patients with diabetes mellitus.

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Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease

Abstract: IR is related to subsequent poorer cognitive performance and greater cognitive decline among patients with cardiovascular disease with and without diabetes.

Cited by 36 publications

References 35 publications

The diabetic brain and cognition

The diabetic brain and cognition

The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?

Cerebral insulin resistance: current concepts of the pathogenesis and possible therapeutic strategies

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