Insulin resistance and levels of adipokines in patients with untreated early rheumatoid arthritis

Manrique‐Arija, Sara; Ureña, I.; Valdivielso, Pedro; Rioja, José; Jiménez-Núñez, F. G.; Irigoyen, M.V.; Fernández‐Nebro, Antonio

doi:10.1007/s10067-015-3106-8

Cited by 18 publications

(42 citation statements)

References 43 publications

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“…This demonstrated a relationship between inflammatory factors and insulin resistance [29–31]. Consistently, there are increased levels of serum inflammatory markers, IL-6, in patients with type 2 diabetes, which can induce beta-cell apoptosis [19, 31–33].…”

Section: Inflammation and Abnormal Glucose Metabolismmentioning

confidence: 87%

Abnormal Glucose Metabolism in Rheumatoid Arthritis

Zhou

Jin

et al. 2017

BioMed Research International

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The incidence of abnormal glucose metabolism in patients with rheumatoid arthritis was considerably higher than the general population. The persistent systemic inflammatory state in rheumatoid arthritis might be associated with the glucose metabolism dysfunction. In this context, insulin resistance, islet β cell apoptosis, inflammatory cytokines, and other aspects which were linked with abnormal glucose metabolism in rheumatoid arthritis were reviewed. This review will be helpful in understanding the abnormal glucose metabolism mechanism in patients with rheumatoid arthritis and might be conducive to finding an effective treatment.

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Section: Inflammation and Abnormal Glucose Metabolismmentioning

confidence: 87%

Abnormal Glucose Metabolism in Rheumatoid Arthritis

Zhou

Jin

et al. 2017

BioMed Research International

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“…However, the association of the role of these substances and their manifestations in the preclinical phase is not well established. Few studies have been conducted on the measurement of adipokines in the early stage, with controversial outcomes …”

Section: Discussionmentioning

confidence: 99%

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

et al. 2019

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Objective:To evaluate the adipokine levels in early rheumatoid arthritis (eRA) and first-degree relatives (FDR) of patients with RA and establish their association with rheumatic disease activity and periodontal variables. Method:A cross-sectional study with eRA patients, FDR and a healthy population.Adipokine levels, clinical, joint radiological indexes and periodontal variables were evaluated. A descriptive, bivariate analysis was performed based on the adipokine levels by χ 2 , Fisher's test and Mann-Whitney U test. A logistic regression was made for associations. Results:High leptin levels were associated with the diagnosis of eRA (odds ratio[OR] = 2.79; 95% CI 1.54-5.07). Early rheumatoid arthritis with high adiponectin levels was less likely to have Multidimensional Health Assessment Questionnaire score >3, body mass index (BMI) >25 and Routine Assessment of Patient Index Data 3 score >12 (OR = 0.16; 95% CI 0.03-0.72). Early rheumatoid arthritis was more likely to present high leptin and interleukin (IL)6 levels with low adiponectin simultaneously (OR = 5.03; 95% CI 1.05-24.0). High leptin levels were associated with the FDR adjusted for IgG2 Porphyromonas gingivalis, swollen joints, P gingivalis and low IL6 (OR = 2.57; 95% CI 1.14-5.95). Conclusion:High adipokine levels in eRA may modulate the disease activity. Having more than 1 adipokine at high serum levels is associated with increased disability, disease activity and BMI, indicating that RA is controlled by adiponectin levels in the early stages of the disease. High leptin levels, presence of P gingivalis and swollen joints may be the factors associated with the development of RA in FDR. K E Y W O R D Sadipokines, adiponectin, leptin, periodontitis, rheumatoid arthritis | 1991 CHAPARRO-SANABRIA et Al.

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“…Возможно, это обусловлено применением менее жестких критериев для определения ИР. В единственном исследовании, в котором использовался сходный критерий (значение HOMA-IR >2,75), частота ИР оказалась гораздо ниже (21%) и сопоставима с полученными нами результатами [16].…”

Section: Discussionunclassified

Insulin resistance in rheumatoid arthritis: relationship to lipid metabolism disorders and metabolic syndrome

Кондратьева¹,

Попкова²,

Nasonov

2019

Naučno-praktičeskaâ revmatologiâ

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Objective:to determine the incidence of insulin resistance (IR) in patients with rheumatoid arthritis (RA) and to assess the relationship of IR to blood lipid profile changes and the presence of metabolic syndrome (MS).Subjects and methods.The investigation enrolled 47 RA patients (41 women and 6 men) without a history of diabetes mellitus (DM) and with normal fasting glucose levels during examination. The patients' median age was 56 [39; 62] years; disease duration – 6 [5; 14] years. Most of the patients had low (40.4%) or moderate (42.6%) RA activity (DAS28). IR was diagnosed using the Homeostastic Model Assessment of Insulin Resistance (HOMA-IR) index 2.77. The presence of MS was assessed by the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII) criteria and the International Diabetes Federation (IDF) criteria.Results and discussion.The median HOMA-IR value in RA patients was 1.7 [1.1; 3.2]. The HOMA-IR index correlated with age (r=0.3; p=0.04), body mass index (r=0.6; p<0.001), waist circumference (r=0.6; p<0.001), and the concentrations of total cholesterol (r=0.3; p=0.02) and triglycerides (TG) (r=0.5; p<0.001). All the patients were divided into two groups: 1) 15 patients with IR; 2) 32 patients without IR. The patients of both groups were matched for sex, age, RA duration and activity, and therapy, but the RA patients with IR more often had abdominal obesity (100.0 and 37.5%), hypertriglyceridemia (33.3 and 6.3%) and the atherogenic index >3.0 (40.0 and 6.3%, respectively; p<0.05 in all cases). MS was diagnosed using the NCEP/ATPIII criteria in 46.7% of cases with RI and in 6.3% of those without IR; MS was identified by the IDF criteria in 60.0 and 12.5% of cases, respectively (p<0.01 in all cases). There were no differences between groups in the incidence of hypertension, myocardial infarction, or in the frequency of surgeries for myocardial revascularization.Conclusion.More than 30% of RA patients without DM have IR (HOMA-IR ≥2.77). IR in RA is associated with obesity, elevated blood TG levels, and a proatherogenic lipid profile. The use of the criteria for MS could not always allows suspect IR in patients with RA.

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Insulin resistance and levels of adipokines in patients with untreated early rheumatoid arthritis

Cited by 18 publications

References 43 publications

Abnormal Glucose Metabolism in Rheumatoid Arthritis

Abnormal Glucose Metabolism in Rheumatoid Arthritis

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

Insulin resistance in rheumatoid arthritis: relationship to lipid metabolism disorders and metabolic syndrome

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