Insulin resistance and platelet count/spleen diameter ratio: Two simple, easy-to-get tests for predicting esophageal varices in cirrhosis #

Insulin resistance in patients with cirrhosis and portal hypertension

“…These two parameters have been validated positively in another independent cohort of 340 patients with cirrhosis. Moreover, there was a positive correlation with the HOMA score and worsening of the hepatic function (33). However, these affirmations have not been accompanied by a hepatic hemodynamic study.…”

Performance of Platelet Count/Spleen Diameter Ratio for Diagnosis of Esophageal Varices in Cirrhosis: A Meta-Analysis

“…According to the QUADAS scale, the methodological quality was not good in all included studies ( Table 2). Four studies met 13 requirements of this scale [10,11,20], 3 studies met 12 [18,21,22], 4 studies met 11 [8,17,23,24], 3 studies met 10 [25][26][27], and the remained met fewer than 10 [9, [28][29][30][31][32].…”

MicroRNAs in Hepatobiliary and Pancreatic Cancers

“…These results indicate that miR-101 may exert its proapoptotic function via targeting Mcl-1 (Su et al, 2009). Li et al (2009) have reported that miR-101 was significantly down-regulated in HCC tissues compared with the matching non-tumor liver tissues. They also showed that miR-101 repressed the expression of v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene, a key component of the activator protein-1 (AP-1) transcription factor.…”

“…In in vitro invasion and migration assays, enhanced miR-101 expression inhibited the invasion and migration of cultured HCC cells. These findings suggest that miR-101 , which is aberrantly expressed in HCC, could repress the expression of the FOS oncogene and may play an important role as a tumor suppressor in HCC (Li et al, 2009). …”